Abstract
Objective: To determine whether prophylactic CNS chemotherapy for childhood acute lymphoblastic leukemia is associated with declines in neuropsychological abilities. Methods: Growth curve analysis was used to examine neuropsychological outcome and treatment-related change in children (N = 30) who were treated at two childhood cancer centers. A comprehensive test battery was administered at baseline (8 months), 2, 3, and 4 years postdiagnosis (age at diagnosis M = 5.90 years, SD = 4.20). Results: Results indicated modest declines in arithmetic, visual motor integration, and verbal fluency. Intrathecal and systemic treatment was related to poorer visual motor integration at 4 years postdiagnosis and a faster rate of decline in visual motor integration skills across the observation period than intrathecal treatment alone. Arithmetic proficiency at 4 years after diagnosis was related to maternal education, but the rate of decline was not. Verbal fluency was unrelated to demographic or treatment variables. Conclusions: These findings suggest that neuropsychological outcome and declines are related to both demographic and treatment characteristics depending on the cognitive domain examined.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Journal of Pediatric Psychology |
| Volume | 26 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2001 |
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Keywords
- Childhood cancer
- CNS late effects
- Growth curve analysis
- Neuropsychology
ASJC Scopus subject areas
- Psychology(all)
- Developmental and Educational Psychology
Cite this
Chemotherapeutic CNS prophylaxis and neuropsychologic change in children with acute lymphoblastic leukemia : A prospective study. / Espy, Kimberly Andrews; Moore, Ida M; Kaufmann, Paul M.; Kramer, Joel H.; Matthay, Katherine; Hutter, John J.
In: Journal of Pediatric Psychology, Vol. 26, No. 1, 2001, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Chemotherapeutic CNS prophylaxis and neuropsychologic change in children with acute lymphoblastic leukemia
T2 - A prospective study
AU - Espy, Kimberly Andrews
AU - Moore, Ida M
AU - Kaufmann, Paul M.
AU - Kramer, Joel H.
AU - Matthay, Katherine
AU - Hutter, John J.
PY - 2001
Y1 - 2001
N2 - Objective: To determine whether prophylactic CNS chemotherapy for childhood acute lymphoblastic leukemia is associated with declines in neuropsychological abilities. Methods: Growth curve analysis was used to examine neuropsychological outcome and treatment-related change in children (N = 30) who were treated at two childhood cancer centers. A comprehensive test battery was administered at baseline (8 months), 2, 3, and 4 years postdiagnosis (age at diagnosis M = 5.90 years, SD = 4.20). Results: Results indicated modest declines in arithmetic, visual motor integration, and verbal fluency. Intrathecal and systemic treatment was related to poorer visual motor integration at 4 years postdiagnosis and a faster rate of decline in visual motor integration skills across the observation period than intrathecal treatment alone. Arithmetic proficiency at 4 years after diagnosis was related to maternal education, but the rate of decline was not. Verbal fluency was unrelated to demographic or treatment variables. Conclusions: These findings suggest that neuropsychological outcome and declines are related to both demographic and treatment characteristics depending on the cognitive domain examined.
AB - Objective: To determine whether prophylactic CNS chemotherapy for childhood acute lymphoblastic leukemia is associated with declines in neuropsychological abilities. Methods: Growth curve analysis was used to examine neuropsychological outcome and treatment-related change in children (N = 30) who were treated at two childhood cancer centers. A comprehensive test battery was administered at baseline (8 months), 2, 3, and 4 years postdiagnosis (age at diagnosis M = 5.90 years, SD = 4.20). Results: Results indicated modest declines in arithmetic, visual motor integration, and verbal fluency. Intrathecal and systemic treatment was related to poorer visual motor integration at 4 years postdiagnosis and a faster rate of decline in visual motor integration skills across the observation period than intrathecal treatment alone. Arithmetic proficiency at 4 years after diagnosis was related to maternal education, but the rate of decline was not. Verbal fluency was unrelated to demographic or treatment variables. Conclusions: These findings suggest that neuropsychological outcome and declines are related to both demographic and treatment characteristics depending on the cognitive domain examined.
KW - Childhood cancer
KW - CNS late effects
KW - Growth curve analysis
KW - Neuropsychology
UR - http://www.scopus.com/inward/record.url?scp=0035143054&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035143054&partnerID=8YFLogxK
U2 - 10.1093/jpepsy/26.1.1
DO - 10.1093/jpepsy/26.1.1
M3 - Article
C2 - 11145727
AN - SCOPUS:0035143054
VL - 26
SP - 1
EP - 9
JO - Journal of Pediatric Psychology
JF - Journal of Pediatric Psychology
SN - 0146-8693
IS - 1
ER -