Chemotherapeutic targeting of myeloid-derived suppressor cells

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9 Scopus citations

Abstract

Myeloid-derived suppressor cells (MDSCs), which expand in cancer-bearing hosts, contribute to the escape of malignant cells from immune destruction and impair the efficacy of immunotherapeutic interventions. We have recently demonstrated that the conventional chemotherapeutic agent doxorubicin selectively eliminates MDSCs, hence promoting the activity of immune effector cells and improving the therapeutic profile of adoptively transferred helper T lymphocytes.

Original languageEnglish (US)
Article numbere27338
JournalOncoImmunology
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2014

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Keywords

  • Cancer
  • Chemoimmunomodulation
  • Doxorubicin
  • Helper T lymphocytes
  • Myeloid-derived suppressor cells
  • ROS

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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