Chemotherapy in advanced ovarian cancer

Four systematic meta-analyses of individual patient data from 37 randomized trials

K. Aabo, M. Adams, P. Adnitt, David S Alberts, A. Athanazziou, V. Barley, D. R. Bell, U. Bianchi, G. Bolis, M. F. Brady, H. S. Brodovsky, H. Bruckner, M. Buyse, R. Canetta, V. Chylak, C. J. Cohen, N. Colombo, P. F. Conte, D. Crowther, J. H. Edmonson & 37 others C. Gennatas, E. Gilbey, M. Gore, D. Guthrie, S. B. Kaye, A. H. Laing, F. Landoni, R. C. Leonard, C. Lewis, P. Y. Liu, C. Mangioni, S. Marsoni, H. Meerpohl, G. A. Omura, M. K B Parmar, J. Pater, S. Pecorelli, M. Presti, W. Sauerbrei, D. V. Skarlos, R. V. Smalley, H. J. Solomon, L. A. Stewart, J. F G Sturgeon, M. H N Tattersall, J. T. Wharton, W. W. Ten Bokkel Huinink, M. Tomirotti, W. Torri, C. Trope, M. M. Turbow, J. B. Vermorken, M. J. Webb, D. W. Wilbur, C. J. Williams, E. Wiltshaw, B. Y. Yeap

Research output: Contribution to journalArticle

218 Citations (Scopus)

Abstract

The purpose of this systematic study was to provide an up to date and reliable quantitative summary of the relative benefits of various types of chemotherapy (non-platinum vs platinum, single-agent vs combination and carboplatin vs cisplatin) in the treatment of advanced ovarian cancer. Also, to investigate whether well-defined patient subgroups benefit more or less from cisplatin- or carboplatin-based therapy. Meta-analyses were based on updated individual patient data from all available randomized controlled trials (published and unpublished), including 37 trials, 5667 patients and 4664 deaths. The results suggest that platinum-based chemotherapy is better than non-platinum therapy, show a trend in favour of platinum combinations over single-agent platinum, and suggest that cisplatin and carboplatin are equally effective. There is no good evidence that cisplatin is more or less effective than carboplatin in any particular subgroup of patients.

Original languageEnglish (US)
Pages (from-to)1479-1487
Number of pages9
JournalBritish Journal of Cancer
Volume78
Issue number11
StatePublished - 1998
Externally publishedYes

Fingerprint

Carboplatin
Platinum
Ovarian Neoplasms
Cisplatin
Meta-Analysis
Drug Therapy
Therapeutics
Randomized Controlled Trials

Keywords

  • Advanced ovarian cancer
  • Chemotherapy
  • Meta-analysis
  • Randomized controlled trials
  • Systematic review

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Chemotherapy in advanced ovarian cancer : Four systematic meta-analyses of individual patient data from 37 randomized trials. / Aabo, K.; Adams, M.; Adnitt, P.; Alberts, David S; Athanazziou, A.; Barley, V.; Bell, D. R.; Bianchi, U.; Bolis, G.; Brady, M. F.; Brodovsky, H. S.; Bruckner, H.; Buyse, M.; Canetta, R.; Chylak, V.; Cohen, C. J.; Colombo, N.; Conte, P. F.; Crowther, D.; Edmonson, J. H.; Gennatas, C.; Gilbey, E.; Gore, M.; Guthrie, D.; Kaye, S. B.; Laing, A. H.; Landoni, F.; Leonard, R. C.; Lewis, C.; Liu, P. Y.; Mangioni, C.; Marsoni, S.; Meerpohl, H.; Omura, G. A.; Parmar, M. K B; Pater, J.; Pecorelli, S.; Presti, M.; Sauerbrei, W.; Skarlos, D. V.; Smalley, R. V.; Solomon, H. J.; Stewart, L. A.; Sturgeon, J. F G; Tattersall, M. H N; Wharton, J. T.; Ten Bokkel Huinink, W. W.; Tomirotti, M.; Torri, W.; Trope, C.; Turbow, M. M.; Vermorken, J. B.; Webb, M. J.; Wilbur, D. W.; Williams, C. J.; Wiltshaw, E.; Yeap, B. Y.

In: British Journal of Cancer, Vol. 78, No. 11, 1998, p. 1479-1487.

Research output: Contribution to journalArticle

Aabo, K, Adams, M, Adnitt, P, Alberts, DS, Athanazziou, A, Barley, V, Bell, DR, Bianchi, U, Bolis, G, Brady, MF, Brodovsky, HS, Bruckner, H, Buyse, M, Canetta, R, Chylak, V, Cohen, CJ, Colombo, N, Conte, PF, Crowther, D, Edmonson, JH, Gennatas, C, Gilbey, E, Gore, M, Guthrie, D, Kaye, SB, Laing, AH, Landoni, F, Leonard, RC, Lewis, C, Liu, PY, Mangioni, C, Marsoni, S, Meerpohl, H, Omura, GA, Parmar, MKB, Pater, J, Pecorelli, S, Presti, M, Sauerbrei, W, Skarlos, DV, Smalley, RV, Solomon, HJ, Stewart, LA, Sturgeon, JFG, Tattersall, MHN, Wharton, JT, Ten Bokkel Huinink, WW, Tomirotti, M, Torri, W, Trope, C, Turbow, MM, Vermorken, JB, Webb, MJ, Wilbur, DW, Williams, CJ, Wiltshaw, E & Yeap, BY 1998, 'Chemotherapy in advanced ovarian cancer: Four systematic meta-analyses of individual patient data from 37 randomized trials', British Journal of Cancer, vol. 78, no. 11, pp. 1479-1487.
Aabo, K. ; Adams, M. ; Adnitt, P. ; Alberts, David S ; Athanazziou, A. ; Barley, V. ; Bell, D. R. ; Bianchi, U. ; Bolis, G. ; Brady, M. F. ; Brodovsky, H. S. ; Bruckner, H. ; Buyse, M. ; Canetta, R. ; Chylak, V. ; Cohen, C. J. ; Colombo, N. ; Conte, P. F. ; Crowther, D. ; Edmonson, J. H. ; Gennatas, C. ; Gilbey, E. ; Gore, M. ; Guthrie, D. ; Kaye, S. B. ; Laing, A. H. ; Landoni, F. ; Leonard, R. C. ; Lewis, C. ; Liu, P. Y. ; Mangioni, C. ; Marsoni, S. ; Meerpohl, H. ; Omura, G. A. ; Parmar, M. K B ; Pater, J. ; Pecorelli, S. ; Presti, M. ; Sauerbrei, W. ; Skarlos, D. V. ; Smalley, R. V. ; Solomon, H. J. ; Stewart, L. A. ; Sturgeon, J. F G ; Tattersall, M. H N ; Wharton, J. T. ; Ten Bokkel Huinink, W. W. ; Tomirotti, M. ; Torri, W. ; Trope, C. ; Turbow, M. M. ; Vermorken, J. B. ; Webb, M. J. ; Wilbur, D. W. ; Williams, C. J. ; Wiltshaw, E. ; Yeap, B. Y. / Chemotherapy in advanced ovarian cancer : Four systematic meta-analyses of individual patient data from 37 randomized trials. In: British Journal of Cancer. 1998 ; Vol. 78, No. 11. pp. 1479-1487.
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abstract = "The purpose of this systematic study was to provide an up to date and reliable quantitative summary of the relative benefits of various types of chemotherapy (non-platinum vs platinum, single-agent vs combination and carboplatin vs cisplatin) in the treatment of advanced ovarian cancer. Also, to investigate whether well-defined patient subgroups benefit more or less from cisplatin- or carboplatin-based therapy. Meta-analyses were based on updated individual patient data from all available randomized controlled trials (published and unpublished), including 37 trials, 5667 patients and 4664 deaths. The results suggest that platinum-based chemotherapy is better than non-platinum therapy, show a trend in favour of platinum combinations over single-agent platinum, and suggest that cisplatin and carboplatin are equally effective. There is no good evidence that cisplatin is more or less effective than carboplatin in any particular subgroup of patients.",
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AU - Adams, M.

AU - Adnitt, P.

AU - Alberts, David S

AU - Athanazziou, A.

AU - Barley, V.

AU - Bell, D. R.

AU - Bianchi, U.

AU - Bolis, G.

AU - Brady, M. F.

AU - Brodovsky, H. S.

AU - Bruckner, H.

AU - Buyse, M.

AU - Canetta, R.

AU - Chylak, V.

AU - Cohen, C. J.

AU - Colombo, N.

AU - Conte, P. F.

AU - Crowther, D.

AU - Edmonson, J. H.

AU - Gennatas, C.

AU - Gilbey, E.

AU - Gore, M.

AU - Guthrie, D.

AU - Kaye, S. B.

AU - Laing, A. H.

AU - Landoni, F.

AU - Leonard, R. C.

AU - Lewis, C.

AU - Liu, P. Y.

AU - Mangioni, C.

AU - Marsoni, S.

AU - Meerpohl, H.

AU - Omura, G. A.

AU - Parmar, M. K B

AU - Pater, J.

AU - Pecorelli, S.

AU - Presti, M.

AU - Sauerbrei, W.

AU - Skarlos, D. V.

AU - Smalley, R. V.

AU - Solomon, H. J.

AU - Stewart, L. A.

AU - Sturgeon, J. F G

AU - Tattersall, M. H N

AU - Wharton, J. T.

AU - Ten Bokkel Huinink, W. W.

AU - Tomirotti, M.

AU - Torri, W.

AU - Trope, C.

AU - Turbow, M. M.

AU - Vermorken, J. B.

AU - Webb, M. J.

AU - Wilbur, D. W.

AU - Williams, C. J.

AU - Wiltshaw, E.

AU - Yeap, B. Y.

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