Chemotherapy of advanced dysgerminoma: Trials of the gynecologic oncology group

Stephen D. Williams, John A. Blessing, Kenneth D Hatch, Howard D. Homesley

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Abstract

Between 1984 and 1989, 20 assessable patients with incompletely resected ovarian dysgerminoma were treated on two protocols of the Gynecologic Oncology Group (GOG). All patients received cisplatin, bleomycin, and either vinblastine or etoposide. More recent patients also received consolidation chemotherapy with vincristine, dactinomycin, and cyclophosphamide (VAC). Eleven patients had clinically measurable disease, and 10 responded completely. Fourteen second-look procedures were done, and all were negative. Currently, 19 of 20 patients are disease-free with median follow-up of 26 months. Cisplatin-based chemotherapy is highly effective in patients with advanced dysgerminoma.

Original languageEnglish (US)
Pages (from-to)1950-1955
Number of pages6
JournalJournal of Clinical Oncology
Volume9
Issue number11
Publication statusPublished - Nov 1991
Externally publishedYes

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Williams, S. D., Blessing, J. A., Hatch, K. D., & Homesley, H. D. (1991). Chemotherapy of advanced dysgerminoma: Trials of the gynecologic oncology group. Journal of Clinical Oncology, 9(11), 1950-1955.