Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study

S. P. Richman, Robert B Livingston, J. U. Gutterman, J. Y. Suen, Evan M Hersh

Research output: Chapter in Book/Report/Conference proceedingChapter

33 Citations (Scopus)

Abstract

Thirty four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus Bacillus Calmette Guerin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug related deaths, and eight other patients required hospitalization for treatment of drug related morbidity.

Original languageEnglish (US)
Title of host publicationCANCER TREAT.REP.
Pages535-539
Number of pages5
Volume60
Edition5
StatePublished - 1976
Externally publishedYes

Fingerprint

Head and Neck Neoplasms
Drug Therapy
Mechlorethamine
Vincristine
Mycobacterium bovis
Pharmaceutical Preparations
Lomustine
Bleomycin
Doxorubicin
Hospitalization
Radiation
Morbidity
Survival

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Richman, S. P., Livingston, R. B., Gutterman, J. U., Suen, J. Y., & Hersh, E. M. (1976). Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study. In CANCER TREAT.REP. (5 ed., Vol. 60, pp. 535-539)

Chemotherapy versus chemoimmunotherapy of head and neck cancer : report of a randomized study. / Richman, S. P.; Livingston, Robert B; Gutterman, J. U.; Suen, J. Y.; Hersh, Evan M.

CANCER TREAT.REP.. Vol. 60 5. ed. 1976. p. 535-539.

Research output: Chapter in Book/Report/Conference proceedingChapter

Richman, SP, Livingston, RB, Gutterman, JU, Suen, JY & Hersh, EM 1976, Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study. in CANCER TREAT.REP.. 5 edn, vol. 60, pp. 535-539.
Richman SP, Livingston RB, Gutterman JU, Suen JY, Hersh EM. Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study. In CANCER TREAT.REP.. 5 ed. Vol. 60. 1976. p. 535-539
Richman, S. P. ; Livingston, Robert B ; Gutterman, J. U. ; Suen, J. Y. ; Hersh, Evan M. / Chemotherapy versus chemoimmunotherapy of head and neck cancer : report of a randomized study. CANCER TREAT.REP.. Vol. 60 5. ed. 1976. pp. 535-539
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