Chemotherapy versus chemoimmunotherapy of head and neck cancer: report of a randomized study

S. P. Richman, R. B. Livingston, J. U. Gutterman, J. Y. Suen, E. M. Hersh

Research output: Contribution to journalArticle

33 Scopus citations

Abstract

Thirty four patients with recurrent squamous cell carcinoma of the head and neck were randomized to receive the five drug chemotherapy regimen BACON (bleomycin, adriamycin, CCNU, vincristine [Oncovin], and mechlorethamine [nitrogen mustard]; 14 patients) or the same regimen plus Bacillus Calmette Guerin (BCG) by scarification (20 patients). The majority of both patient groups had received prior surgery and radiation. The patients treated with BACON plus BCG experienced a significantly longer survival (P = 0.014) than those treated with BACON alone. There were five drug related deaths, and eight other patients required hospitalization for treatment of drug related morbidity.

Original languageEnglish (US)
Pages (from-to)535-539
Number of pages5
JournalCANCER TREAT.REP.
Volume60
Issue number5
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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