Childhood cancer symptom cluster: Leukemia and health-related quality of life

Cheryl C. Rodgers, Mary C. Hooke, Olga A. Taylor, Kari M. Koerner, Pauline A. Mitby, Ida M. Moore, Michael E. Scheurer, Marilyn J. Hockenberry, Wei Pan

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

OBJECTIVES: To examine the relationship of the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L) with health-related quality of life (HRQOL). SAMPLE & SETTING: 327 children receiving treatment for acute lymphoblastic leukemia from four pediatric oncology programs across the United States. METHODS & VARIABLES: Participants completed fatigue, sleep disturbance, pain, nausea, and depression symptom questionnaires at four time points; these symptoms comprised the CCSC-L. HRQOL was measured at the start of postinduction therapy and then at the start of maintenance therapy. Relationships between the CCSC-L and HRQOL scores were examined with longitudinal parallelprocess modeling. RESULTS: The mean HRQOL significantly increased over time (p < 0.001). The CCSC-L had a significant negative association with HRQOL scores at the start of postinduction therapy (b = -0.53, p < 0.005) and the start of maintenance therapy (b = -0.33, p < 0.015). Participants with more severe symptoms in the CCSC-L over time had significantly lower HRQOL at the start of maintenance therapy (b = -0.42, p < 0.005). IMPLICATIONS FOR NURSING: Nurses are pivotal in providing management strategies to minimize symptom severity that may improve HRQOL.

Original languageEnglish (US)
Pages (from-to)228-237
Number of pages10
JournalOncology nursing forum
Volume46
Issue number2
DOIs
StatePublished - Mar 2019

Keywords

  • Health-related quality of life
  • Pediatric oncology
  • Symptom cluster

ASJC Scopus subject areas

  • Oncology(nursing)

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    Rodgers, C. C., Hooke, M. C., Taylor, O. A., Koerner, K. M., Mitby, P. A., Moore, I. M., Scheurer, M. E., Hockenberry, M. J., & Pan, W. (2019). Childhood cancer symptom cluster: Leukemia and health-related quality of life. Oncology nursing forum, 46(2), 228-237. https://doi.org/10.1188/19.ONF.228-237