Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life

Cheryl C. Rodgers, Mary C. Hooke, Olga A. Taylor, Kari M. Koerner, Pauline A. Mitby, Ida M Moore, Michael E. Scheurer, Marilyn J. Hockenberry, Wei Pan

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

OBJECTIVES: To examine the relationship of the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L) with health-related quality of life (HRQOL). SAMPLE &AMP; SETTING: 327 children receiving treatment for acute lymphoblastic leukemia from four pediatric oncology programs across the United States. METHODS &AMP; VARIABLES: Participants completed fatigue, sleep disturbance, pain, nausea, and depression symptom questionnaires at four time points; these symptoms comprised the CCSC-L. HRQOL was measured at the start of postinduction therapy and then at the start of maintenance therapy. Relationships between the CCSC-L and HRQOL scores were examined with longitudinal parallel-process modeling. RESULTS: The mean HRQOL significantly increased over time (p < 0.001). The CCSC-L had a significant negative association with HRQOL scores at the start of postinduction therapy (beta = -0.53, p < 0.005) and the start of maintenance therapy (beta = -0.33, p < 0.015). Participants with more severe symptoms in the CCSC-L over time had significantly lower HRQOL at the start of maintenance therapy (beta = -0.42, p < 0.005). IMPLICATIONS FOR NURSING: Nurses are pivotal in providing management strategies to minimize symptom severity that may improve HRQOL.

Original languageEnglish (US)
Pages (from-to)228-237
Number of pages10
JournalOncology nursing forum
Volume46
Issue number2
DOIs
StatePublished - Mar 1 2019

Fingerprint

Leukemia
Quality of Life
Neoplasms
Adenosine Monophosphate
Therapeutics
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Nausea
Fatigue
Sleep
Nursing
Nurses
Depression
Pediatrics
Pain

Keywords

  • health-related quality of life
  • pediatric oncology
  • symptom cluster

ASJC Scopus subject areas

  • Oncology(nursing)

Cite this

Rodgers, C. C., Hooke, M. C., Taylor, O. A., Koerner, K. M., Mitby, P. A., Moore, I. M., ... Pan, W. (2019). Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life. Oncology nursing forum, 46(2), 228-237. https://doi.org/10.1188/19.ONF.228-237

Childhood Cancer Symptom Cluster : Leukemia and Health-Related Quality of Life. / Rodgers, Cheryl C.; Hooke, Mary C.; Taylor, Olga A.; Koerner, Kari M.; Mitby, Pauline A.; Moore, Ida M; Scheurer, Michael E.; Hockenberry, Marilyn J.; Pan, Wei.

In: Oncology nursing forum, Vol. 46, No. 2, 01.03.2019, p. 228-237.

Research output: Contribution to journalArticle

Rodgers, CC, Hooke, MC, Taylor, OA, Koerner, KM, Mitby, PA, Moore, IM, Scheurer, ME, Hockenberry, MJ & Pan, W 2019, 'Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life', Oncology nursing forum, vol. 46, no. 2, pp. 228-237. https://doi.org/10.1188/19.ONF.228-237
Rodgers, Cheryl C. ; Hooke, Mary C. ; Taylor, Olga A. ; Koerner, Kari M. ; Mitby, Pauline A. ; Moore, Ida M ; Scheurer, Michael E. ; Hockenberry, Marilyn J. ; Pan, Wei. / Childhood Cancer Symptom Cluster : Leukemia and Health-Related Quality of Life. In: Oncology nursing forum. 2019 ; Vol. 46, No. 2. pp. 228-237.
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