Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life

Cheryl C. Rodgers, Mary C. Hooke, Olga A. Taylor, Kari M. Koerner, Pauline A. Mitby, Ida M Moore, Michael E. Scheurer, Marilyn J. Hockenberry, Wei Pan

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

OBJECTIVES: To examine the relationship of the Childhood Cancer Symptom Cluster-Leukemia (CCSC-L) with health-related quality of life (HRQOL). SAMPLE &AMP; SETTING: 327 children receiving treatment for acute lymphoblastic leukemia from four pediatric oncology programs across the United States. METHODS &AMP; VARIABLES: Participants completed fatigue, sleep disturbance, pain, nausea, and depression symptom questionnaires at four time points; these symptoms comprised the CCSC-L. HRQOL was measured at the start of postinduction therapy and then at the start of maintenance therapy. Relationships between the CCSC-L and HRQOL scores were examined with longitudinal parallel-process modeling. RESULTS: The mean HRQOL significantly increased over time (p < 0.001). The CCSC-L had a significant negative association with HRQOL scores at the start of postinduction therapy (beta = -0.53, p < 0.005) and the start of maintenance therapy (beta = -0.33, p < 0.015). Participants with more severe symptoms in the CCSC-L over time had significantly lower HRQOL at the start of maintenance therapy (beta = -0.42, p < 0.005). IMPLICATIONS FOR NURSING: Nurses are pivotal in providing management strategies to minimize symptom severity that may improve HRQOL.

Original languageEnglish (US)
Pages (from-to)228-237
Number of pages10
JournalOncology nursing forum
Volume46
Issue number2
DOIs
StatePublished - Mar 1 2019

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Keywords

  • health-related quality of life
  • pediatric oncology
  • symptom cluster

ASJC Scopus subject areas

  • Oncology(nursing)

Cite this

Rodgers, C. C., Hooke, M. C., Taylor, O. A., Koerner, K. M., Mitby, P. A., Moore, I. M., Scheurer, M. E., Hockenberry, M. J., & Pan, W. (2019). Childhood Cancer Symptom Cluster: Leukemia and Health-Related Quality of Life. Oncology nursing forum, 46(2), 228-237. https://doi.org/10.1188/19.ONF.228-237