Chirality of coiled coils: Elasticity matters

Sébastien Neukirch, Alain Goriely, Andrew Hausrath

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Coiled coils are important protein-protein interaction motifs with high specificity that are used to assemble macromolecular complexes. Their simple geometric organization, consisting of α helices wrapped around each other, confers remarkable mechanical properties. A geometrical and mechanical continuous model taking into account sequence effects and based on the superhelical winding of the constituent helices is introduced, and a continuous family of solutions in which the oligomerization interactions are satisfied is derived. From these solutions, geometric and structural properties, such as the chirality and pitch of the coiled coil and the location of residues, are obtained. The theoretical predictions are compared to x-ray data from the leucine zipper motif.

Original languageEnglish (US)
Article number038105
JournalPhysical Review Letters
Volume100
Issue number3
DOIs
StatePublished - Jan 25 2008

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chirality
helices
coils
elastic properties
zippers
proteins
leucine
interactions
mechanical properties
predictions
x rays

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Cite this

Chirality of coiled coils : Elasticity matters. / Neukirch, Sébastien; Goriely, Alain; Hausrath, Andrew.

In: Physical Review Letters, Vol. 100, No. 3, 038105, 25.01.2008.

Research output: Contribution to journalArticle

Neukirch, Sébastien ; Goriely, Alain ; Hausrath, Andrew. / Chirality of coiled coils : Elasticity matters. In: Physical Review Letters. 2008 ; Vol. 100, No. 3.
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