CHK it out! Blocking WEE kinase routs TP53 mutant cancer

Julie E. Bauman, Christine H. Chung

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.

Original languageEnglish (US)
Pages (from-to)4173-4175
Number of pages3
JournalClinical Cancer Research
Volume20
Issue number16
DOIs
StatePublished - Aug 15 2014
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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