TY - JOUR
T1 - CHK it out! Blocking WEE kinase routs TP53 mutant cancer
AU - Bauman, Julie E.
AU - Chung, Christine H.
PY - 2014/8/15
Y1 - 2014/8/15
N2 - Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.
AB - Mutations in TP53, encoding the master tumor suppressor p53, have posed a developmental therapeutic dilemma due to inability to target loss of function. Inhibition of WEE1 or CHK1 kinase, negative regulators of the G2-M checkpoint, selectively sensitizes p53-deficient cells to exogenous DNA damage, abrogating G2 arrest and precipitating mitotic catastrophe.
UR - http://www.scopus.com/inward/record.url?scp=84905973961&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84905973961&partnerID=8YFLogxK
U2 - 10.1158/1078-0432.CCR-14-0720
DO - 10.1158/1078-0432.CCR-14-0720
M3 - Article
C2 - 25125257
AN - SCOPUS:84905973961
VL - 20
SP - 4173
EP - 4175
JO - Clinical Cancer Research
JF - Clinical Cancer Research
SN - 1078-0432
IS - 16
ER -