Chloro polyketides from the cultured fungus (Aspergillus) separated from a marine sponge

Leif M. Abrell, Bethel Borgeson, Phillip Crews

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

The salt water culture of Aspergillus ?ochraceus separated from the Indo-Pacific sponge Jaspis cf. coriacea has yielded two new chlorine containing polyketides, chlorocarolide A (1a) and B (1b). These compounds have an overall structural analogy to carolic acid whose biosynthesis has been intensely studied. The structures and stereochemical features of the chlorocarolides are reported. Also noted are the similarities of their α-methylene-γ-butyrolactones to those of the litsenolides and mahubenolides, both derived from plants.

Original languageEnglish (US)
Pages (from-to)2331-2334
Number of pages4
JournalTetrahedron Letters
Volume37
Issue number14
DOIs
StatePublished - Apr 1 1996

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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