Chloro polyketides from the cultured fungus (Aspergillus) separated from a marine sponge

Leif M. Abrell, Bethel Borgeson, Phillip Crews

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


The salt water culture of Aspergillus ?ochraceus separated from the Indo-Pacific sponge Jaspis cf. coriacea has yielded two new chlorine containing polyketides, chlorocarolide A (1a) and B (1b). These compounds have an overall structural analogy to carolic acid whose biosynthesis has been intensely studied. The structures and stereochemical features of the chlorocarolides are reported. Also noted are the similarities of their α-methylene-γ-butyrolactones to those of the litsenolides and mahubenolides, both derived from plants.

Original languageEnglish (US)
Pages (from-to)2331-2334
Number of pages4
JournalTetrahedron Letters
Issue number14
StatePublished - Apr 1 1996
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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