Chlorpromazine effects upon rabbit lens water and electrolyte balance

Cathryn C. Wilson, Nicholas A. Delamere, Christopher A. Paterson

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Chlorpromazine (CPZ) concentrations of 5 × 10-5 m or greater were found to disrupt lens electrolyte and water balance significantly. Lens sodium and calcium levels increased while potassium decreased. These changes were accompanied by water accumulation. Such effects of CPZ were not dependent upon exposure to ultraviolet light. Electrical measurements revealed that CPZ induced depolarization of the lens potential but little change of overall lens conductance. 86Rb efflux from the lens was unaltered by a 1 hr exposure to CPZ. The active sodium pump in the lens was inhibited by CPZ, as evidenced by a reduction in Na- K-ATPase activity.

Original languageEnglish (US)
Pages (from-to)559-565
Number of pages7
JournalExperimental eye research
Volume36
Issue number4
DOIs
StatePublished - Apr 1983
Externally publishedYes

Keywords

  • calcium
  • cataract
  • chlorpromazine
  • lens hydration
  • permeability
  • potassium
  • rabbit lens
  • sodium
  • sodium pump

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Chlorpromazine effects upon rabbit lens water and electrolyte balance'. Together they form a unique fingerprint.

  • Cite this