Choice of statistical model in observational studies of ART

Laura E. Dodge, Leslie V. Farland, Katharine F.B. Correia, Stacey A. Missmer, Emily A. Seidler, Jack Wilkinson, Anna M. Modest, Michele R. Hacker

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Analyzing data on ART presents unique and sometimes complicated challenges related to choosing the unit(s) of analysis and the statistical model. In this commentary, we provide examples of how these challenges arise and guidance for overcoming them. We discuss the implications of different ways to count treatment cycles, considering the perspectives of research questions, data management and analysis and patient counseling. We present the advantages and disadvantages of different statistical models, and finally, we discuss the definition and calculation of the cumulative incidence of live birth, which is a key outcome of research on ART.

Original languageEnglish (US)
Pages (from-to)1499-1504
Number of pages6
JournalHuman Reproduction
Volume35
Issue number7
DOIs
StatePublished - Jul 1 2020

Keywords

  • Assisted reproductive technologies
  • Data analysis
  • Data reporting
  • Research methods
  • Statistical models

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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