Cholecystokinin and neuropeptide Y receptors on single rabbit vagal afferent ganglion neurons: site of prejunctional modulation of visceral sensory neurons

Joseph R. Ghilardi, Clark J. Allen, Steven R. Vigna, Douglas C. McVey, Patrick W. Mantyh

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

A [125I]cholecystokinin (CCK) analog and [125I]peptide YY (PYY) were used to localize and characterize CCK and neuropeptide Y (NPY) receptor binding sites in the rabbit vagal afferent (nodose) ganglion. High concentrations of CCK and NPY binding sites were observed in 10.6% and 9.2% of the nodose ganglion neurons, respectively. Pharmacological experiments using CCK or NPY analogs suggest that both subtypes of CCK (CCK-A and CCK-B) and NPY (Y1 and Y2) receptor binding sites are expressed by discrete populations of neurons in the nodose ganglion. These results suggest sites at which CCK or NPY, released in either the nucleus of the solitary tract or a peripheral tissue, may modulate the release of neurotransmitters from a select population of visceral primary afferent neurons. Possible functions mediated by these receptors include modulation of satiety, opiate analgesia, and the development of morphine tolerance.

Original languageEnglish (US)
Pages (from-to)33-40
Number of pages8
JournalBrain Research
Volume633
Issue number1-2
DOIs
StatePublished - Jan 7 1994
Externally publishedYes

Keywords

  • Analgesia
  • Cholecystokinin
  • Neuropeptide Y
  • Nodose
  • Receptor
  • Satiety
  • Vagal afferent ganglion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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