Cholesteryl ester transfer protein and lecithin

Cholesterol acyltransferase activities in hispanic and anglo postmenopausal women: Associations with total and regional body fat

Kathryn A. Greaves, Scott B Going, Maria Luz Fernandez, Laura A. Milliken, Timothy G Lohman, Tamsen L Bassford, Donald J. McNamara

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Reverse cholesterol transport is one process by which high-density lipoprotein (HDL) cholesterol has been hypothesized to play a role in reducing the risk of coronary heart disease. This study was designed to examine cholesteryl ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT) activities, 2 modulators of reverse cholesterol transport, in Hispanic and Anglo postmenopausal women. The associations between plasma CETP and LCAT activities and body composition were also examined. Of the 199 subjects, 33% were of Hispanic origin and 47% were undergoing hormone replacement therapy (HRT). Body composition was measured by dual-energy x-ray absorptiometry (DXA) and anthropometry. Plasma CETP activity was higher in Hispanic compared to Anglo women, although the difference was eliminated when data were adjusted for abdominal fat. Hispanic women had lower plasma HDL cholesterol concentrations, higher total cholesterol:HDL cholesterol ratios and triglyceride concentrations, and greater susceptibility of low-density lipoprotein (LDL) particles to oxidation. Hispanic women also had a significantly greater relative deposition of body fat on the trunk and intra-abdominally than did Anglo women, even after adjusting for total body fat. There were no significant ethnic differences in LCAT activity. Plasma CETP and LCAT activities were negatively correlated with HDL cholesterol and positively correlated with total cholesterol, LDL cholesterol, and triglycerides, as well as total and regional body composition variables. In conclusion, results suggest a greater risk for coronary heart disease in, Hispanic women compared to Anglo women.

Original languageEnglish (US)
Pages (from-to)282-289
Number of pages8
JournalMetabolism: Clinical and Experimental
Volume52
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Cholesterol Ester Transfer Proteins
Phosphatidylcholine-Sterol O-Acyltransferase
Hispanic Americans
Adipose Tissue
HDL Cholesterol
Body Composition
Cholesterol
Blood Proteins
Coronary Disease
Abdominal Fat
Anthropometry
Hormone Replacement Therapy
LDL Lipoproteins
LDL Cholesterol
X-Rays

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Cholesteryl ester transfer protein and lecithin : Cholesterol acyltransferase activities in hispanic and anglo postmenopausal women: Associations with total and regional body fat. / Greaves, Kathryn A.; Going, Scott B; Fernandez, Maria Luz; Milliken, Laura A.; Lohman, Timothy G; Bassford, Tamsen L; McNamara, Donald J.

In: Metabolism: Clinical and Experimental, Vol. 52, No. 3, 01.03.2003, p. 282-289.

Research output: Contribution to journalArticle

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