Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: A positron emission tomography regional cerebral blood flow study in healthy humans

Maura L. Furey, Pietro Pietrini, Gene E Alexander, Mark B. Schapiro, Barry Horwitz

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Previously, we have shown that physostigmine, an acetylcholinesterase inhibitor, improved performance on a working memory for faces task, as reflected by reduced reaction time (RT), and reduced task-specific regional cerebral blood flow (rCBF) in right prefrontal cortex and, further, that these reductions in RT and right frontal rCBF were significantly correlated. Here we investigated the relation between the effects of physostigmine on task performance and task-specific functional brain response throughout the cortex by examining correlations between physostigmine-related changes in rCBF in all brain areas and changes in RT. In subjects who received an infusion of physostigmine, reduced RT correlated (p < 0.001) positively with reduced rCBF in right frontal cortex, left temporal cortex, anterior cingulate, and left hippocampus; and correlated with increased rCBF in medial occipital visual cortex. In subjects who received a placebo infusion of saline, no significant correlations between changes in RT and cortical rCBF were observed. The results show that cholinergically induced improvements in working memory performance are related to alterations in neural activity in multiple cortical regions, including increased neural activity in regions associated with early perceptual processing and decreased neural activity in regions associated with attention, memory encoding, and memory maintenance. Copyright (C) 2000 Elsevier Science Inc.

Original languageEnglish (US)
Pages (from-to)213-218
Number of pages6
JournalBrain Research Bulletin
Volume51
Issue number3
DOIs
StatePublished - Feb 2000
Externally publishedYes

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Cerebrovascular Circulation
Regional Blood Flow
Short-Term Memory
Positron-Emission Tomography
Cholinergic Agents
Physostigmine
Reaction Time
Brain
Occipital Lobe
Cholinesterase Inhibitors
Gyrus Cinguli
Task Performance and Analysis
Frontal Lobe
Visual Cortex
Temporal Lobe
Prefrontal Cortex
Hippocampus
Placebos
Maintenance

Keywords

  • Cognition
  • PET
  • Physostigmine
  • rCBF
  • Working memory

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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title = "Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions: A positron emission tomography regional cerebral blood flow study in healthy humans",
abstract = "Previously, we have shown that physostigmine, an acetylcholinesterase inhibitor, improved performance on a working memory for faces task, as reflected by reduced reaction time (RT), and reduced task-specific regional cerebral blood flow (rCBF) in right prefrontal cortex and, further, that these reductions in RT and right frontal rCBF were significantly correlated. Here we investigated the relation between the effects of physostigmine on task performance and task-specific functional brain response throughout the cortex by examining correlations between physostigmine-related changes in rCBF in all brain areas and changes in RT. In subjects who received an infusion of physostigmine, reduced RT correlated (p < 0.001) positively with reduced rCBF in right frontal cortex, left temporal cortex, anterior cingulate, and left hippocampus; and correlated with increased rCBF in medial occipital visual cortex. In subjects who received a placebo infusion of saline, no significant correlations between changes in RT and cortical rCBF were observed. The results show that cholinergically induced improvements in working memory performance are related to alterations in neural activity in multiple cortical regions, including increased neural activity in regions associated with early perceptual processing and decreased neural activity in regions associated with attention, memory encoding, and memory maintenance. Copyright (C) 2000 Elsevier Science Inc.",
keywords = "Cognition, PET, Physostigmine, rCBF, Working memory",
author = "Furey, {Maura L.} and Pietro Pietrini and Alexander, {Gene E} and Schapiro, {Mark B.} and Barry Horwitz",
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T1 - Cholinergic enhancement improves performance on working memory by modulating the functional activity in distinct brain regions

T2 - A positron emission tomography regional cerebral blood flow study in healthy humans

AU - Furey, Maura L.

AU - Pietrini, Pietro

AU - Alexander, Gene E

AU - Schapiro, Mark B.

AU - Horwitz, Barry

PY - 2000/2

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N2 - Previously, we have shown that physostigmine, an acetylcholinesterase inhibitor, improved performance on a working memory for faces task, as reflected by reduced reaction time (RT), and reduced task-specific regional cerebral blood flow (rCBF) in right prefrontal cortex and, further, that these reductions in RT and right frontal rCBF were significantly correlated. Here we investigated the relation between the effects of physostigmine on task performance and task-specific functional brain response throughout the cortex by examining correlations between physostigmine-related changes in rCBF in all brain areas and changes in RT. In subjects who received an infusion of physostigmine, reduced RT correlated (p < 0.001) positively with reduced rCBF in right frontal cortex, left temporal cortex, anterior cingulate, and left hippocampus; and correlated with increased rCBF in medial occipital visual cortex. In subjects who received a placebo infusion of saline, no significant correlations between changes in RT and cortical rCBF were observed. The results show that cholinergically induced improvements in working memory performance are related to alterations in neural activity in multiple cortical regions, including increased neural activity in regions associated with early perceptual processing and decreased neural activity in regions associated with attention, memory encoding, and memory maintenance. Copyright (C) 2000 Elsevier Science Inc.

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