Cholinergic-sympathetic interactions in the left atrium and left ventricle of conscious dogs

Steven Goldman, M. Olajos, E. Morkin

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The extent of cholinergic-sympathetic interaction in the heart was examined in the resting control state and after isoproterenol stimulation in eight conscious dogs. Sonomicrometer crystals and solid-state pressure transducers were implanted in the left atrium and the left ventricle to evaluate mechanical function while heart rate was held constant by atrial pacing. Edrophonium (0.5 mg/kg i.v.) was given as a single dose at rest and during increased sympathetic tone produced by continuous infusion of isoproterenol (0.08 μg/kg/min). In the control state, edrophonium administration caused no change in left ventricular dP/dt, fractional shortening or velocity of contraction, but produced significant (P < .001) decreases in left atrial fractional shortening and contraction velocity. During isoproterenol infusion there were significant increases in dP/dt, the velocity of contraction and fractional shortening in both left atrium and ventricle (P < .001). Administration of edrophonium during this increase in inotropic state produced significant (P < .01) decreases in left ventricular dP/dt, fractional shortening and contraction velocity. Moreover, after edrophonium, left atrial fractional shortening and velocity of contraction were decreased to values that were significantly (P < .001) less than control. Thus, cholinergic stimulation caused selective depression of left atrial systolic function at rest and depression of both left atrial and ventricular function during sympathetic stimulation.

Original languageEnglish (US)
Pages (from-to)219-223
Number of pages5
JournalJournal of Pharmacology and Experimental Therapeutics
Volume225
Issue number1
StatePublished - 1983
Externally publishedYes

Fingerprint

Edrophonium
Heart Atria
Cholinergic Agents
Heart Ventricles
Left Atrial Function
Isoproterenol
Dogs
Pressure Transducers
Left Ventricular Function
Heart Rate

ASJC Scopus subject areas

  • Pharmacology

Cite this

Cholinergic-sympathetic interactions in the left atrium and left ventricle of conscious dogs. / Goldman, Steven; Olajos, M.; Morkin, E.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 225, No. 1, 1983, p. 219-223.

Research output: Contribution to journalArticle

@article{c9e03430d8364decbcf26353d2c23bea,
title = "Cholinergic-sympathetic interactions in the left atrium and left ventricle of conscious dogs",
abstract = "The extent of cholinergic-sympathetic interaction in the heart was examined in the resting control state and after isoproterenol stimulation in eight conscious dogs. Sonomicrometer crystals and solid-state pressure transducers were implanted in the left atrium and the left ventricle to evaluate mechanical function while heart rate was held constant by atrial pacing. Edrophonium (0.5 mg/kg i.v.) was given as a single dose at rest and during increased sympathetic tone produced by continuous infusion of isoproterenol (0.08 μg/kg/min). In the control state, edrophonium administration caused no change in left ventricular dP/dt, fractional shortening or velocity of contraction, but produced significant (P < .001) decreases in left atrial fractional shortening and contraction velocity. During isoproterenol infusion there were significant increases in dP/dt, the velocity of contraction and fractional shortening in both left atrium and ventricle (P < .001). Administration of edrophonium during this increase in inotropic state produced significant (P < .01) decreases in left ventricular dP/dt, fractional shortening and contraction velocity. Moreover, after edrophonium, left atrial fractional shortening and velocity of contraction were decreased to values that were significantly (P < .001) less than control. Thus, cholinergic stimulation caused selective depression of left atrial systolic function at rest and depression of both left atrial and ventricular function during sympathetic stimulation.",
author = "Steven Goldman and M. Olajos and E. Morkin",
year = "1983",
language = "English (US)",
volume = "225",
pages = "219--223",
journal = "Journal of Pharmacology and Experimental Therapeutics",
issn = "0022-3565",
publisher = "American Society for Pharmacology and Experimental Therapeutics",
number = "1",

}

TY - JOUR

T1 - Cholinergic-sympathetic interactions in the left atrium and left ventricle of conscious dogs

AU - Goldman, Steven

AU - Olajos, M.

AU - Morkin, E.

PY - 1983

Y1 - 1983

N2 - The extent of cholinergic-sympathetic interaction in the heart was examined in the resting control state and after isoproterenol stimulation in eight conscious dogs. Sonomicrometer crystals and solid-state pressure transducers were implanted in the left atrium and the left ventricle to evaluate mechanical function while heart rate was held constant by atrial pacing. Edrophonium (0.5 mg/kg i.v.) was given as a single dose at rest and during increased sympathetic tone produced by continuous infusion of isoproterenol (0.08 μg/kg/min). In the control state, edrophonium administration caused no change in left ventricular dP/dt, fractional shortening or velocity of contraction, but produced significant (P < .001) decreases in left atrial fractional shortening and contraction velocity. During isoproterenol infusion there were significant increases in dP/dt, the velocity of contraction and fractional shortening in both left atrium and ventricle (P < .001). Administration of edrophonium during this increase in inotropic state produced significant (P < .01) decreases in left ventricular dP/dt, fractional shortening and contraction velocity. Moreover, after edrophonium, left atrial fractional shortening and velocity of contraction were decreased to values that were significantly (P < .001) less than control. Thus, cholinergic stimulation caused selective depression of left atrial systolic function at rest and depression of both left atrial and ventricular function during sympathetic stimulation.

AB - The extent of cholinergic-sympathetic interaction in the heart was examined in the resting control state and after isoproterenol stimulation in eight conscious dogs. Sonomicrometer crystals and solid-state pressure transducers were implanted in the left atrium and the left ventricle to evaluate mechanical function while heart rate was held constant by atrial pacing. Edrophonium (0.5 mg/kg i.v.) was given as a single dose at rest and during increased sympathetic tone produced by continuous infusion of isoproterenol (0.08 μg/kg/min). In the control state, edrophonium administration caused no change in left ventricular dP/dt, fractional shortening or velocity of contraction, but produced significant (P < .001) decreases in left atrial fractional shortening and contraction velocity. During isoproterenol infusion there were significant increases in dP/dt, the velocity of contraction and fractional shortening in both left atrium and ventricle (P < .001). Administration of edrophonium during this increase in inotropic state produced significant (P < .01) decreases in left ventricular dP/dt, fractional shortening and contraction velocity. Moreover, after edrophonium, left atrial fractional shortening and velocity of contraction were decreased to values that were significantly (P < .001) less than control. Thus, cholinergic stimulation caused selective depression of left atrial systolic function at rest and depression of both left atrial and ventricular function during sympathetic stimulation.

UR - http://www.scopus.com/inward/record.url?scp=0020630844&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020630844&partnerID=8YFLogxK

M3 - Article

C2 - 6834273

AN - SCOPUS:0020630844

VL - 225

SP - 219

EP - 223

JO - Journal of Pharmacology and Experimental Therapeutics

JF - Journal of Pharmacology and Experimental Therapeutics

SN - 0022-3565

IS - 1

ER -