Chord-based versus voxel-based methods of electron transport in the skeletal tissues

Amish P. Shah, Derek W. Jokisch, Didier A. Rajon, Christopher J Watchman, Phillip W. Patton, Wesley E. Bolch

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Anatomic models needed for internal dose assessment have traditionally been developed using mathematical surface equations to define organ boundaries, shapes, and their positions within the body. Many researchers, however, are now advocating the use of tomographic models created from segmented patient computed tomography (CT) or magnetic resonance (MR) scans. In the skeleton, however, the tissue structures of the bone trabeculae, marrow cavities, and endosteal layer are exceedingly small and of complex shape, and thus do not lend themselves easily to either stylistic representations or in-vivo CT imaging. Historically, the problem of modeling the skeletal tissues has been addressed through the development of chord-based methods of radiation particle transport, as given by studies at the University of Leeds (Leeds, UK) using a 44-year male subject. We have proposed an alternative approach to skeletal dosimetry in which excised sections of marrow-intact cadaver spongiosa are imaged directly via microCT scanning. The cadaver selected for initial investigation of this technique was a 66-year male subject of nominal body mass index (22.7 kg m-2). The objectives of the present study were to compare chord-based versus voxel-based methods of skeletal dosimetry using data from the UF 66-year male subject. Good agreement between chord-based and voxel-based transport was noted for marrow irradiation by either bone surface or bone volume sources up to 500-1000 keV (depending upon the skeletal site). In contrast, chord-based models of electron transport yielded consistently lower values of the self-absorbed fraction to marrow tissues than seen under voxel-based transport at energies above 100 keV, a feature directly attributed to the inability of chord-based models to account for nonlinear electron trajectories. Significant differences were also noted in the dosimetry of the endosteal layer (for all source tissues), with chord-based transport predicting a higher fraction of energy deposition than given by voxel-based transport (average factor of about 1.6). The study supports future use of voxel-based skeletal models which (1) permit nonlinear electron trajectories across the skeletal tissues, (2) do not rely on mathematical algorithms for treating the endosteal tissue layer, and (3) do not implicitly assume independence of marrow and bone trajectories as is the case for chord-based skeletal models.

Original languageEnglish (US)
Pages (from-to)3151-3159
Number of pages9
JournalMedical Physics
Volume32
Issue number10
DOIs
StatePublished - Oct 2005
Externally publishedYes

Fingerprint

Electron Transport
Bone Marrow
Cadaver
Tomography
Electrons
Anatomic Models
Bone and Bones
X-Ray Microtomography
Skeleton
Body Mass Index
Magnetic Resonance Spectroscopy
Research Personnel
Radiation

Keywords

  • Absorbed fraction
  • Bone marrow
  • Chord-based radiation transport
  • Skeletal dosimetry
  • Voxel-based radiation transport

ASJC Scopus subject areas

  • Biophysics

Cite this

Shah, A. P., Jokisch, D. W., Rajon, D. A., Watchman, C. J., Patton, P. W., & Bolch, W. E. (2005). Chord-based versus voxel-based methods of electron transport in the skeletal tissues. Medical Physics, 32(10), 3151-3159. https://doi.org/10.1118/1.2040712

Chord-based versus voxel-based methods of electron transport in the skeletal tissues. / Shah, Amish P.; Jokisch, Derek W.; Rajon, Didier A.; Watchman, Christopher J; Patton, Phillip W.; Bolch, Wesley E.

In: Medical Physics, Vol. 32, No. 10, 10.2005, p. 3151-3159.

Research output: Contribution to journalArticle

Shah, AP, Jokisch, DW, Rajon, DA, Watchman, CJ, Patton, PW & Bolch, WE 2005, 'Chord-based versus voxel-based methods of electron transport in the skeletal tissues', Medical Physics, vol. 32, no. 10, pp. 3151-3159. https://doi.org/10.1118/1.2040712
Shah, Amish P. ; Jokisch, Derek W. ; Rajon, Didier A. ; Watchman, Christopher J ; Patton, Phillip W. ; Bolch, Wesley E. / Chord-based versus voxel-based methods of electron transport in the skeletal tissues. In: Medical Physics. 2005 ; Vol. 32, No. 10. pp. 3151-3159.
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