Chromosome transfer experiments link regions on chromosome 7 to radiation resistance in human glioblastoma multiforme

Anjan Misra, Malgorzata Pellarin, Lily Hu, Sandeep Kunwar, Mark Perhouse, Kathleen R. Lamborn, Dennis F. Deen, Burt G. Feuerstein

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Glioblastoma multiforme (GM) is the most lethal form of brain tumor, with a median survival of approximately 1 year. Treatment options are limited. Radiation therapy is a common form of treatment, but many tumors are resistant. In earlier studies, we found that gain of chromosome 7 is associated with radiation resistance in human primary GM. In this study, we extend that result to a model system in which we transferred chromosome 7 to recipient cells and confirmed radiation resistance as a function of chromosome 7 gain. We identified three candidate regions on chromosome 7 that conferred radiation resistance in our model system.

Original languageEnglish (US)
Pages (from-to)20-30
Number of pages11
JournalGenes Chromosomes and Cancer
Volume45
Issue number1
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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