Chronic fluoxetine treatment up‐regulates dopamine receptors in the mesolimbic forebrain of the rat

Ronald P. Hammer, Jody E. Margulies, Allison B. Lynn, Linda S. Brady

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The mechanism of antidepressant function is still largely unknown. The authors examined the binding of [H] SCH 23390 and [3H] spiperone to dopantine D1‐ and D2‐like receptors, respectively, using quantitative in vitro receptor autoradiogra‐phy inforebrain sections front rats treated for 8 weeks with 5 mg/kg fluoxetine HCl or vehicle. Fluoxetine treatment significantly increased dopamine D1 receptor density in the nucleus accumbens and D2 density in the nucleus accumbens, olfactory tubercle and islands of Calleja region. Neither D1 nor D2 receptors were significantly affected in the striatum. The results are discussed in light of additional evidence that antidepressants alter mesolimbic dopamine function. Although fluoxetine (Prozac) selectively inhibits reuptake of serotonin, its indirect effects on mesolimbic dopamine systems might underlie its potent efficacy as an antidepressant. Depression 1:82–87 (1993). © 1993 Wiley‐Liss, Inc.

Original languageEnglish (US)
Pages (from-to)82-87
Number of pages6
JournalDepression
Volume1
Issue number2
DOIs
StatePublished - 1993
Externally publishedYes

Keywords

  • D
  • D
  • antidepressants
  • dopamine
  • nucleus accumbens
  • serotonin

ASJC Scopus subject areas

  • Psychiatry and Mental health

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