Chronology of halothane-induced antigen expression in halothane-exposed rabbits

T. P. Roth, A. K. Hubbard, A. J. Gandolfi, B. R. Brown

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Multiple halothane exposures in rabbits generate modified liver proteins or antigens that appear to incorporate the metabolic intermediate of halothane, trifluoroacetyl halide (TFA), as identified by specific anti-TFA antibody. These halothane-induced antigens are most prevalent throughout the second to fourth days following a single halothane exposure and are in highest concentration after the second and third exposure. In addition, five consecutive halothane exposures at 2-week intervals caused the sustained expression of these halothane-induced antigens throughout the first 4 days following the last exposure. By the seventh day, however, antigen expression began to decline. Although there is great heterogeneity in the molecular weights of the halothane-induced antigens, the predominant proteins appear to be 85k, 58k, 53k, 37k and 24k. These liver proteins could reflect self proteins altered by trifluoroacetylation by halothane metabolites and may be potential immunogens in the initiation of a halothane-induced immune response.

Original languageEnglish (US)
Pages (from-to)330-336
Number of pages7
JournalClinical and Experimental Immunology
Volume72
Issue number2
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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