Cigarette smoking and ethane exhalation in humans

Michael P Habib, N. C. Clements, H. S. Garewal

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The time course of exhaled ethane gas was determined in the alveolar expirate of healthy, fasting smokers and nonsmokers after smoking a cigarette. Baseline ethane was measured by gas chromatography and corrected for background ethane after a 2-min washout using purified air. Ethane was measured immediately after smoking and hourly thereafter. Ethane was highest immediately after smoking, reflecting ethane in cigarette smoke. An exponential decline of ethane in smokers returned ethane to baseline within 3 h. Ethane in nonsmokers also peaked immediately after smoking but returned to baseline by 1 h. Ethane from smokers, measured 3 h after the last cigarette, was compared with ethane from healthy ex-smokers and nonsmokers. Mean (± SEM) baseline ethane in smokers was 2.90 ± 0.52 pmol/min/kg, 1.55 ± 0.36 pmol/min/kg in ex-smokers and 1.11 ± 0.26 pmol/min/kg in nonsmokers (p < 0.05). Ethane in two smokers measured before and after a week of oral beta carotene supplementation (60 mg/d) fell by 80 and 35%. We conclude that cigarette smokers have increased baseline ethane in exhaled breath compared with non-smokers. Trials with antioxidant agents are warranted to assess their ability to reduce expired ethane levels.

Original languageEnglish (US)
Pages (from-to)1368-1372
Number of pages5
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume151
Issue number5
StatePublished - 1995

Fingerprint

Exhalation
Ethane
Smoking
Tobacco Products
Aptitude
beta Carotene

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Cigarette smoking and ethane exhalation in humans. / Habib, Michael P; Clements, N. C.; Garewal, H. S.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 151, No. 5, 1995, p. 1368-1372.

Research output: Contribution to journalArticle

Habib, Michael P ; Clements, N. C. ; Garewal, H. S. / Cigarette smoking and ethane exhalation in humans. In: American Journal of Respiratory and Critical Care Medicine. 1995 ; Vol. 151, No. 5. pp. 1368-1372.
@article{d98521f0ac7e4f04927fad7214c6b712,
title = "Cigarette smoking and ethane exhalation in humans",
abstract = "The time course of exhaled ethane gas was determined in the alveolar expirate of healthy, fasting smokers and nonsmokers after smoking a cigarette. Baseline ethane was measured by gas chromatography and corrected for background ethane after a 2-min washout using purified air. Ethane was measured immediately after smoking and hourly thereafter. Ethane was highest immediately after smoking, reflecting ethane in cigarette smoke. An exponential decline of ethane in smokers returned ethane to baseline within 3 h. Ethane in nonsmokers also peaked immediately after smoking but returned to baseline by 1 h. Ethane from smokers, measured 3 h after the last cigarette, was compared with ethane from healthy ex-smokers and nonsmokers. Mean (± SEM) baseline ethane in smokers was 2.90 ± 0.52 pmol/min/kg, 1.55 ± 0.36 pmol/min/kg in ex-smokers and 1.11 ± 0.26 pmol/min/kg in nonsmokers (p < 0.05). Ethane in two smokers measured before and after a week of oral beta carotene supplementation (60 mg/d) fell by 80 and 35{\%}. We conclude that cigarette smokers have increased baseline ethane in exhaled breath compared with non-smokers. Trials with antioxidant agents are warranted to assess their ability to reduce expired ethane levels.",
author = "Habib, {Michael P} and Clements, {N. C.} and Garewal, {H. S.}",
year = "1995",
language = "English (US)",
volume = "151",
pages = "1368--1372",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "5",

}

TY - JOUR

T1 - Cigarette smoking and ethane exhalation in humans

AU - Habib, Michael P

AU - Clements, N. C.

AU - Garewal, H. S.

PY - 1995

Y1 - 1995

N2 - The time course of exhaled ethane gas was determined in the alveolar expirate of healthy, fasting smokers and nonsmokers after smoking a cigarette. Baseline ethane was measured by gas chromatography and corrected for background ethane after a 2-min washout using purified air. Ethane was measured immediately after smoking and hourly thereafter. Ethane was highest immediately after smoking, reflecting ethane in cigarette smoke. An exponential decline of ethane in smokers returned ethane to baseline within 3 h. Ethane in nonsmokers also peaked immediately after smoking but returned to baseline by 1 h. Ethane from smokers, measured 3 h after the last cigarette, was compared with ethane from healthy ex-smokers and nonsmokers. Mean (± SEM) baseline ethane in smokers was 2.90 ± 0.52 pmol/min/kg, 1.55 ± 0.36 pmol/min/kg in ex-smokers and 1.11 ± 0.26 pmol/min/kg in nonsmokers (p < 0.05). Ethane in two smokers measured before and after a week of oral beta carotene supplementation (60 mg/d) fell by 80 and 35%. We conclude that cigarette smokers have increased baseline ethane in exhaled breath compared with non-smokers. Trials with antioxidant agents are warranted to assess their ability to reduce expired ethane levels.

AB - The time course of exhaled ethane gas was determined in the alveolar expirate of healthy, fasting smokers and nonsmokers after smoking a cigarette. Baseline ethane was measured by gas chromatography and corrected for background ethane after a 2-min washout using purified air. Ethane was measured immediately after smoking and hourly thereafter. Ethane was highest immediately after smoking, reflecting ethane in cigarette smoke. An exponential decline of ethane in smokers returned ethane to baseline within 3 h. Ethane in nonsmokers also peaked immediately after smoking but returned to baseline by 1 h. Ethane from smokers, measured 3 h after the last cigarette, was compared with ethane from healthy ex-smokers and nonsmokers. Mean (± SEM) baseline ethane in smokers was 2.90 ± 0.52 pmol/min/kg, 1.55 ± 0.36 pmol/min/kg in ex-smokers and 1.11 ± 0.26 pmol/min/kg in nonsmokers (p < 0.05). Ethane in two smokers measured before and after a week of oral beta carotene supplementation (60 mg/d) fell by 80 and 35%. We conclude that cigarette smokers have increased baseline ethane in exhaled breath compared with non-smokers. Trials with antioxidant agents are warranted to assess their ability to reduce expired ethane levels.

UR - http://www.scopus.com/inward/record.url?scp=0029024150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029024150&partnerID=8YFLogxK

M3 - Article

C2 - 7735586

AN - SCOPUS:0029024150

VL - 151

SP - 1368

EP - 1372

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 5

ER -