Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk

Robert C. Millikan, Gary S. Pittman, Beth Newman, Chiu Kit J Tse, Ornella Selmin, Beverly Rockhill, David Savitz, Patricia G. Moorman, Douglas A. Bell

Research output: Contribution to journalArticle

168 Citations (Scopus)

Abstract

To examine the effects of smoking and N-acetylation genetics on breast cancer risk, we analyzed data from an ongoing, population-based, case- control study of invasive breast cancer in North Carolina. The study population consisted of 498 cases and 473 controls, with approximately equal numbers of African-American and white women, and women under the age of 50 and age 50 years or older. Among premenopausal women, there was no association between current smoking [odds ratio (OR), 0.9; 95% confidence interval (CI), 0.5-1.5] or past smoking (OR, 1.0; 95% CI, 0.6-1.6) and breast cancer risk. Among postmenopausal women, there was also no association with current smoking (OR, 1.2; 95% CI, 0.7-2.0); however, a small increase in risk was observed for past smoking (OR, 1.5; 95% CI, 1.0-2.4). For postmenopausal women who smoked in the past, ORs and 95% CIs were 3.4 (1.4-8.1) for smoking within the past 3 years, 3.0 (1.3-6.7) for smoking 4-9 years ago, and 0.6 (0.3-1.4) for smoking 10-19 years ago. Neither N-acetyltransferase 1 (NAT1) nor N-acetyltransferase 2 (NAT2) genotype alone was associated with increased breast cancer risk. There was little evidence for modification of smoking effects according to genotype, except among postmenopausal women. Among postmenopausal women, ORs for smoking within the past 3 years were greater for women with the NAT1*10 genotype (OR, 9.0; 95% CI, 1.9-41.8) than NAT1- non*10 (OR, 2.5; 95% CI, 0.9-7.2) and greater for NAT2-rapid genotype (OR, 7.4; 95% CI, 1.6-32.6) than NAT2-slow (OR, 2.8; 95% CI, 0.4-8.0). Future studies of NAT genotypes and breast cancer should investigate the effects of environmental tobacco smoke, diet, and other exposures.

Original languageEnglish (US)
Pages (from-to)371-378
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume7
Issue number5
StatePublished - May 1998
Externally publishedYes

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Smoking
Breast Neoplasms
Odds Ratio
Confidence Intervals
Genotype
Acetyltransferases
N-acetyltransferase 1
Acetylation
Smoke
African Americans
Population
Tobacco
Case-Control Studies
Diet

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

Millikan, R. C., Pittman, G. S., Newman, B., Tse, C. K. J., Selmin, O., Rockhill, B., ... Bell, D. A. (1998). Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk. Cancer Epidemiology Biomarkers and Prevention, 7(5), 371-378.

Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk. / Millikan, Robert C.; Pittman, Gary S.; Newman, Beth; Tse, Chiu Kit J; Selmin, Ornella; Rockhill, Beverly; Savitz, David; Moorman, Patricia G.; Bell, Douglas A.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 7, No. 5, 05.1998, p. 371-378.

Research output: Contribution to journalArticle

Millikan, RC, Pittman, GS, Newman, B, Tse, CKJ, Selmin, O, Rockhill, B, Savitz, D, Moorman, PG & Bell, DA 1998, 'Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk', Cancer Epidemiology Biomarkers and Prevention, vol. 7, no. 5, pp. 371-378.
Millikan RC, Pittman GS, Newman B, Tse CKJ, Selmin O, Rockhill B et al. Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk. Cancer Epidemiology Biomarkers and Prevention. 1998 May;7(5):371-378.
Millikan, Robert C. ; Pittman, Gary S. ; Newman, Beth ; Tse, Chiu Kit J ; Selmin, Ornella ; Rockhill, Beverly ; Savitz, David ; Moorman, Patricia G. ; Bell, Douglas A. / Cigarette smoking, N-acetyltransferases 1 and 2, and breast cancer risk. In: Cancer Epidemiology Biomarkers and Prevention. 1998 ; Vol. 7, No. 5. pp. 371-378.
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