Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis

FREDERICK J. KOGAN, RICHARD E. SAMPLINER, MICHAEL MAYERSOHN, RODNEY M. KAZAMA, DONALD PERRIER, WILLIAM JONES, ULRICH F. MICHAEL

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Abstract: Cimetidine disposition was determined in six patients undergoing continuous ambulatory peritoneal dialysis to ascertain the need for modification of conventional dosing regimens. Blood, dialysis fluid, and urine were collected for 48 hours after administration of a single intravenous dose of cimetidine. The following values were obtained: elimination half‐life, 4.3 hours; systemic or total body clearance, 191 ± 55 ml/min; and dialysis clearance, 4.2 ± 3.1 ml/min. Approximately 2% of a cimetidine dose is removed by dialysis, indicating that there is no need to adjust the conventional renal failure dosing regimen in patients undergoing continuous ambulatory peritoneal dialysis. 1983 American College of Clinical Pharmacology

Original languageEnglish (US)
Pages (from-to)252-256
Number of pages5
JournalThe Journal of Clinical Pharmacology
Volume23
Issue number5-6
DOIs
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis'. Together they form a unique fingerprint.

  • Cite this

    KOGAN, FREDERICK. J., SAMPLINER, RICHARD. E., MAYERSOHN, MICHAEL., KAZAMA, RODNEY. M., PERRIER, DONALD., JONES, WILLIAM., & MICHAEL, ULRICH. F. (1983). Cimetidine Disposition in Patients Undergoing Continuous Ambulatory Peritoneal Dialysis. The Journal of Clinical Pharmacology, 23(5-6), 252-256. https://doi.org/10.1002/j.1552-4604.1983.tb02732.x