Ciprofloxacin attachment to porous-coated titanium surfaces

D. S. Dunn, Srini Raghavan, R. G. Volz

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A simple and effective method for attaching ciprofloxacin HCl salt to the surface of porous coated titanium based orthopedic materials was developed. The method utilizes the electrophoretic migration of both fine ciprofloxacin HCl particles and ciprofloxacin ions to deposit the antibiotic salt on a positively biased surface. The quantity of antibiotic deposited can be easily and effectively controlled by varying the time of deposition and applied voltage. In vitro tests have indicated that the antimicrobial activity of the treated surfaces is retained for a period of 5 days. The method allows a significant amount of antibiotic to be deposited and could theoretically be used to deliver antibiotics to the tissues surrounding prosthetic devices in order to prevent postoperative infections.

Original languageEnglish (US)
Pages (from-to)325-331
Number of pages7
JournalJournal of applied biomaterials : an official journal of the Society for Biomaterials
Volume5
Issue number4
StatePublished - Dec 1994

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Antibiotics
Titanium
Salts
Orthopedics
Prosthetics
Deposits
Tissue
Ions
Electric potential

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Ciprofloxacin attachment to porous-coated titanium surfaces. / Dunn, D. S.; Raghavan, Srini; Volz, R. G.

In: Journal of applied biomaterials : an official journal of the Society for Biomaterials, Vol. 5, No. 4, 12.1994, p. 325-331.

Research output: Contribution to journalArticle

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