Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose

Mary C. Birmingham, Ross Guarino, Allen Heller, John H. Wilton, Anita Shah, Linda Hejmanowski, David E. Nix, Jerome J. Schentag

Research output: Contribution to journalArticle

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Abstract

Intravenous ciprofloxacin is frequently prescribed for the treatment of infections due to nosocomially acquired Gram-negative organisms, including those originating in the respiratory tract. In this study, the concentrations of ciprofloxacin in serum and lung tissue were determined by HPLC in patients undergoing lung surgery. A total of 22 patients scheduled for lung surgery received a single 400 mg iv dose of ciprofloxacin administered as a 1 h infusion. A specimen of healthy lung tissue was obtained from resected lung from 18 of the patients for analysis of ciprofloxacin concentration during the following time intervals after infusion (one sample/patient): 0-2, 2-4, 4-8 and 8-12 h. Corresponding mean serum and tissue concentrations were 2.37 mg/L and 3.84 mg/kg (0-2 h), 1.18 mg/L and 1.92 mg/kg (2-4 h), 0.69 mg/L and 1.77 mg/kg (4-8 h), and 0.13 mg/L and 0.67 mg/kg (8-12 h). Ciprofloxacin distributed rapidly to lung tissue, as seen by the high concentrations in the lung tissue as early as 2 h after infusion. Concentrations in lung tissue were generally higher than those in serum (tissue:serum ratios ranged from 1.7 to 7.1). The mean tissue concentrations found in this study remained above the MIC for most susceptible organisms.

Original languageEnglish (US)
Pages (from-to)43-48
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume43
Issue numberSUPPL. A
StatePublished - 1999
Externally publishedYes

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Ciprofloxacin
Lung
Serum
Respiratory System
High Pressure Liquid Chromatography
Infection

ASJC Scopus subject areas

  • Pharmacology
  • Microbiology

Cite this

Birmingham, M. C., Guarino, R., Heller, A., Wilton, J. H., Shah, A., Hejmanowski, L., ... Schentag, J. J. (1999). Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose. Journal of Antimicrobial Chemotherapy, 43(SUPPL. A), 43-48.

Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose. / Birmingham, Mary C.; Guarino, Ross; Heller, Allen; Wilton, John H.; Shah, Anita; Hejmanowski, Linda; Nix, David E.; Schentag, Jerome J.

In: Journal of Antimicrobial Chemotherapy, Vol. 43, No. SUPPL. A, 1999, p. 43-48.

Research output: Contribution to journalArticle

Birmingham, MC, Guarino, R, Heller, A, Wilton, JH, Shah, A, Hejmanowski, L, Nix, DE & Schentag, JJ 1999, 'Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose', Journal of Antimicrobial Chemotherapy, vol. 43, no. SUPPL. A, pp. 43-48.
Birmingham MC, Guarino R, Heller A, Wilton JH, Shah A, Hejmanowski L et al. Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose. Journal of Antimicrobial Chemotherapy. 1999;43(SUPPL. A):43-48.
Birmingham, Mary C. ; Guarino, Ross ; Heller, Allen ; Wilton, John H. ; Shah, Anita ; Hejmanowski, Linda ; Nix, David E. ; Schentag, Jerome J. / Ciprofloxacin concentrations in lung tissue following a single 400 mg intravenous dose. In: Journal of Antimicrobial Chemotherapy. 1999 ; Vol. 43, No. SUPPL. A. pp. 43-48.
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