Ciprofloxacin-Induced Granulomatous Interstitial Nephritis and Localized Elastolysis

Yeong Hau H. Lien, Ronald Hansen, William F. Kern, Jerry Bangert, Raymond B. Nagle, Marcia Ko, Mark S. Siskind

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Ciprofloxacin is known to cause acute interstitial nephritis. We report the first case of ciprofloxacin-induced granulomatous interstitial nephritis and localized elastolysis. The patient presented with acute renal failure and skin lesions following a 14-day course of ciprofloxacin administered for cellulitis. The patient had symmetric, palm-sized, tender violaceous plaques on both axillae. The renal biopsy revealed granulomatous interstitial disease. A skin biopsy revealed an elastolytic process with histocytic infiltration and calcification. After discontinuing ciprofloxacin and starting a short course of steroid therapy, the skin lesion and renal function improved promptly. The nephritis relapsed after prednisone was discontinued and responded to a second course of steroid therapy. Ciprofloxacin, like penicillin, can cause granulomatous interstitial nephritis and elastolysis. A prolonged course of steroid therapy may be indicated in patients with ciprofloxacin-induced granulomatous interstitial nephritis to avoid early relapse.

Original languageEnglish (US)
Pages (from-to)598-602
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume22
Issue number4
DOIs
StatePublished - 1993

Keywords

  • Granulomatous interstitial nephritis
  • acute renal failure
  • cell-mediated immunity
  • elastolysis
  • steroid therapy

ASJC Scopus subject areas

  • Nephrology

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