Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying

E. Spanos, J. W. Pike, M. R. Haussler, K. W. Colston, I. M.A. Evans, A. M. Goldner, T. A. McCain, I. MacIntyre

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Abstract

In order to investigate possible modulation of vitamin D metabolism by prolactin, circulating 1α,25-dihydroxyvitamin D (1α,25-(OH)2D) was measured by radioreceptor assay in chicks given injections of prolactin for five days. At a dose of 100 μg/day, the lactogenic hormone elicited a two-fold increase in plasma 1α,25-(OH)2D. This effect may explain the known action of prolactin in producing hypercalcemia and could be physiologically important in birds. The laying hen represents a physiologic state in which calcuim absorption is known to be stimulated and prolactin has been reported to be elevated. Assay of serum 1α,25-(OH)2D in the laying hen demonstrates a nine-fold enhancement over non-laying controls. Since this marked increase during egg laying is at least partially mimicked by injecting prolactin, a possible causative relationship between elevated prolactin and 1α,25-(OH)2D is suggested.

Original languageEnglish (US)
Pages (from-to)1751-1756
Number of pages6
JournalLife Sciences
Volume19
Issue number11
DOIs
StatePublished - Dec 1 1976

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Spanos, E., Pike, J. W., Haussler, M. R., Colston, K. W., Evans, I. M. A., Goldner, A. M., McCain, T. A., & MacIntyre, I. (1976). Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying. Life Sciences, 19(11), 1751-1756. https://doi.org/10.1016/0024-3205(76)90083-7