Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying

E. Spanos, J. W. Pike, Mark R Haussler, K. W. Colston, I. M A Evans, A. M. Goldner, T. A. McCain, I. MacIntyre

Research output: Contribution to journalArticle

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Abstract

In order to investigate possible modulation of vitamin D metabolism by prolactin, circulating 1α,25-dihydroxyvitamin D (1α,25-(OH)2D) was measured by radioreceptor assay in chicks given injections of prolactin for five days. At a dose of 100 μg/day, the lactogenic hormone elicited a two-fold increase in plasma 1α,25-(OH)2D. This effect may explain the known action of prolactin in producing hypercalcemia and could be physiologically important in birds. The laying hen represents a physiologic state in which calcuim absorption is known to be stimulated and prolactin has been reported to be elevated. Assay of serum 1α,25-(OH)2D in the laying hen demonstrates a nine-fold enhancement over non-laying controls. Since this marked increase during egg laying is at least partially mimicked by injecting prolactin, a possible causative relationship between elevated prolactin and 1α,25-(OH)2D is suggested.

Original languageEnglish (US)
Pages (from-to)1751-1756
Number of pages6
JournalLife Sciences
Volume19
Issue number11
DOIs
StatePublished - Dec 1 1976
Externally publishedYes

Fingerprint

Prolactin
Ovum
Chickens
Injections
Assays
Radioligand Assay
Birds
Hypercalcemia
Metabolism
Vitamin D
1,25-dihydroxyvitamin D
Modulation
Hormones
Plasmas
Serum

ASJC Scopus subject areas

  • Pharmacology

Cite this

Circulating 1α,25-dihydroxyvitamin D in the chicken : Enhancement by injection of prolactin and during egg laying. / Spanos, E.; Pike, J. W.; Haussler, Mark R; Colston, K. W.; Evans, I. M A; Goldner, A. M.; McCain, T. A.; MacIntyre, I.

In: Life Sciences, Vol. 19, No. 11, 01.12.1976, p. 1751-1756.

Research output: Contribution to journalArticle

Spanos, E, Pike, JW, Haussler, MR, Colston, KW, Evans, IMA, Goldner, AM, McCain, TA & MacIntyre, I 1976, 'Circulating 1α,25-dihydroxyvitamin D in the chicken: Enhancement by injection of prolactin and during egg laying', Life Sciences, vol. 19, no. 11, pp. 1751-1756. https://doi.org/10.1016/0024-3205(76)90083-7
Spanos, E. ; Pike, J. W. ; Haussler, Mark R ; Colston, K. W. ; Evans, I. M A ; Goldner, A. M. ; McCain, T. A. ; MacIntyre, I. / Circulating 1α,25-dihydroxyvitamin D in the chicken : Enhancement by injection of prolactin and during egg laying. In: Life Sciences. 1976 ; Vol. 19, No. 11. pp. 1751-1756.
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AU - Colston, K. W.

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