TY - JOUR
T1 - Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations
AU - Midttun, Øivind
AU - Theofylaktopoulou, Despoina
AU - McCann, Adrian
AU - Fanidi, Anouar
AU - Muller, David C.
AU - Meyer, Klaus
AU - Ulvik, Arve
AU - Zheng, Wei
AU - Shu, Xiao Ou
AU - Xiang, Yong Bing
AU - Prentice, Ross
AU - Thomson, Cynthia A.
AU - Pettinger, Mary
AU - Giles, Graham G.
AU - Hodge, Allison
AU - Cai, Qiuyin
AU - Blot, William J.
AU - Wu, Jie
AU - Johansson, Mikael
AU - Hultdin, Johan
AU - Grankvist, Kjell
AU - Stevens, Victoria L.
AU - McCullough, Marjorie L.
AU - Weinstein, Stephanie J.
AU - Albanes, Demetrius
AU - Langhammer, Arnulf
AU - Hveem, Kristian
AU - Næss, Marit
AU - Sesso, Howard D.
AU - Gaziano, J. Michael
AU - Buring, Julie E.
AU - Lee, I. Min
AU - Severi, Gianluca
AU - Zhang, Xuehong
AU - Han, Jiali
AU - Stampfer, Meir J.
AU - Smith-Warner, Stephanie A.
AU - Zeleniuch-Jacquotte, Anne
AU - Le Marchand, Loic
AU - Yuan, Jian Min
AU - Butler, Lesley M.
AU - Koh, Woon Puay
AU - Wang, Renwei
AU - Gao, Yu Tang
AU - Ericson, Ulrika
AU - Sonestedt, Emily
AU - Ziegler, Regina G.
AU - Freedman, Neal D.
AU - Visvanathan, Kala
AU - Jones, Miranda R.
AU - Relton, Caroline
AU - Brennan, Paul
AU - Johansson, Mattias
AU - Ueland, Per M.
N1 - Funding Information:
Supported by the NIH/National Cancer Institute (NCI) [grant 1U01CA155340-01; to the Lung Cancer Cohort Consortium (LC3)], the Australian National Health and Medical Research Committee (grant 1050198; to the LC3), the US NCI [grants R37 CA070867 and UM1 CA182910 (to the Shanghai Women's Health Study), R01 CA082729 and UM1 CA173640 (to the Shanghai Men's Health Study), and R01 CA092447 and U01 CA202979 (to the Southern Community Cohort Study). The Multiethnic Cohort Study was funded in part by grant U01 CA164973. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study is supported by the Intramural Research Program of the US NCI, NIH, and by US Public Health Service contract HHSN261201500005C from the NCI, Department of Health and Human Services (DHHS). The Campaign Against Cancer and Stroke and the Campaign Against Cancer and Heart Disease acknowledge the State of Maryland, the Maryland Cigarette Restitution Fund, and the National Program of Cancer Registries of the CDC for funds that support the collection and availability of the cancer registry data. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial is supported by contracts from the Division of Cancer Prevention and intramural research funding from the Division of Cancer Epidemiology and Genetics, NCI, US NIH, DHHS. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial was supported by the NIH (grants, UM1CA167552, UM1CA186107, P01CA87969, and R01CA49449). CR is supported by Cancer Research UK grant (C18281/A19169) and the Medical Research Council Integrative Epidemiology Unit at the University of Bristol with funds from the Medical Research Council (MC-UU-12013/2) and the University of Bristol. This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).
Publisher Copyright:
© 2017 American Society for Nutrition.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.
AB - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.
KW - Biomarker
KW - Lung Cancer Cohort Consortium
KW - One-carbon metabolism
KW - Tryptophan metabolism
KW - Vitamin status
UR - http://www.scopus.com/inward/record.url?scp=85020506629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020506629&partnerID=8YFLogxK
U2 - 10.3945/ajcn.116.151241
DO - 10.3945/ajcn.116.151241
M3 - Article
C2 - 28424186
AN - SCOPUS:85020506629
VL - 105
SP - 1314
EP - 1326
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 6
ER -