Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations

Øivind Midttun; Despoina Theofylaktopoulou; Adrian McCann; Anouar Fanidi; David C. Muller; Klaus Meyer; Arve Ulvik; Wei Zheng; Xiao Ou Shu; Yong Bing Xiang; Ross Prentice; Cynthia A. Thomson; Mary Pettinger; Graham G. Giles; Allison Hodge; Qiuyin Cai; William J. Blot; Jie Wu; Mikael Johansson; Johan Hultdin; Kjell Grankvist; Victoria L. Stevens; Marjorie L. McCullough; Stephanie J. Weinstein; Demetrius Albanes; Arnulf Langhammer; Kristian Hveem; Marit Næss; Howard D. Sesso; J. Michael Gaziano; Julie E. Buring; I. Min Lee; Gianluca Severi; Xuehong Zhang; Jiali Han; Meir J. Stampfer; Stephanie A. Smith-Warner; Anne Zeleniuch-Jacquotte; Loic Le Marchand; Jian Min Yuan; Lesley M. Butler; Woon Puay Koh; Renwei Wang; Yu Tang Gao; Ulrika Ericson; Emily Sonestedt; Regina G. Ziegler; Neal D. Freedman; Kala Visvanathan; Miranda R. Jones; Caroline Relton; Paul Brennan; Mattias Johansson; Per M. Ueland

doi:10.3945/ajcn.116.151241

Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations

Øivind Midttun, Despoina Theofylaktopoulou, Adrian McCann, Anouar Fanidi, David C. Muller, Klaus Meyer, Arve Ulvik, Wei Zheng, Xiao Ou Shu, Yong Bing Xiang, Ross Prentice, Cynthia A. Thomson, Mary Pettinger, Graham G. Giles, Allison Hodge, Qiuyin Cai, William J. Blot, Jie Wu, Mikael Johansson, Johan HultdinKjell Grankvist, Victoria L. Stevens, Marjorie L. McCullough, Stephanie J. Weinstein, Demetrius Albanes, Arnulf Langhammer, Kristian Hveem, Marit Næss, Howard D. Sesso, J. Michael Gaziano, Julie E. Buring, I. Min Lee, Gianluca Severi, Xuehong Zhang, Jiali Han, Meir J. Stampfer, Stephanie A. Smith-Warner, Anne Zeleniuch-Jacquotte, Loic Le Marchand, Jian Min Yuan, Lesley M. Butler, Woon Puay Koh, Renwei Wang, Yu Tang Gao, Ulrika Ericson, Emily Sonestedt, Regina G. Ziegler, Neal D. Freedman, Kala Visvanathan, Miranda R. Jones, Caroline Relton, Paul Brennan, Mattias Johansson, Per M. Ueland

Health Promotion Sciences

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

Original language	English (US)
Pages (from-to)	1314-1326
Number of pages	13
Journal	American Journal of Clinical Nutrition
Volume	105
Issue number	6
DOIs	https://doi.org/10.3945/ajcn.116.151241
State	Published - Jun 1 2017

Keywords

Biomarker
Lung Cancer Cohort Consortium
One-carbon metabolism
Tryptophan metabolism
Vitamin status

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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Midttun, Ø., Theofylaktopoulou, D., McCann, A., Fanidi, A., Muller, D. C., Meyer, K., Ulvik, A., Zheng, W., Shu, X. O., Xiang, Y. B., Prentice, R., Thomson, C. A., Pettinger, M., Giles, G. G., Hodge, A., Cai, Q., Blot, W. J., Wu, J., Johansson, M., ... Ueland, P. M. (2017). Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. American Journal of Clinical Nutrition, 105(6), 1314-1326. https://doi.org/10.3945/ajcn.116.151241

Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. / Midttun, Øivind; Theofylaktopoulou, Despoina; McCann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao Ou; Xiang, Yong Bing; Prentice, Ross; Thomson, Cynthia A.; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I. Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian Min; Butler, Lesley M.; Koh, Woon Puay; Wang, Renwei; Gao, Yu Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per M.

In: American Journal of Clinical Nutrition, Vol. 105, No. 6, 01.06.2017, p. 1314-1326.

Research output: Contribution to journal › Article › peer-review

Midttun, Ø, Theofylaktopoulou, D, McCann, A, Fanidi, A, Muller, DC, Meyer, K, Ulvik, A, Zheng, W, Shu, XO, Xiang, YB, Prentice, R, Thomson, CA, Pettinger, M, Giles, GG, Hodge, A, Cai, Q, Blot, WJ, Wu, J, Johansson, M, Hultdin, J, Grankvist, K, Stevens, VL, McCullough, ML, Weinstein, SJ, Albanes, D, Langhammer, A, Hveem, K, Næss, M, Sesso, HD, Gaziano, JM, Buring, JE, Lee, IM, Severi, G, Zhang, X, Han, J, Stampfer, MJ, Smith-Warner, SA, Zeleniuch-Jacquotte, A, Le Marchand, L, Yuan, JM, Butler, LM, Koh, WP, Wang, R, Gao, YT, Ericson, U, Sonestedt, E, Ziegler, RG, Freedman, ND, Visvanathan, K, Jones, MR, Relton, C, Brennan, P, Johansson, M & Ueland, PM 2017, 'Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations', American Journal of Clinical Nutrition, vol. 105, no. 6, pp. 1314-1326. https://doi.org/10.3945/ajcn.116.151241

Midttun, Øivind ; Theofylaktopoulou, Despoina ; McCann, Adrian ; Fanidi, Anouar ; Muller, David C. ; Meyer, Klaus ; Ulvik, Arve ; Zheng, Wei ; Shu, Xiao Ou ; Xiang, Yong Bing ; Prentice, Ross ; Thomson, Cynthia A. ; Pettinger, Mary ; Giles, Graham G. ; Hodge, Allison ; Cai, Qiuyin ; Blot, William J. ; Wu, Jie ; Johansson, Mikael ; Hultdin, Johan ; Grankvist, Kjell ; Stevens, Victoria L. ; McCullough, Marjorie L. ; Weinstein, Stephanie J. ; Albanes, Demetrius ; Langhammer, Arnulf ; Hveem, Kristian ; Næss, Marit ; Sesso, Howard D. ; Gaziano, J. Michael ; Buring, Julie E. ; Lee, I. Min ; Severi, Gianluca ; Zhang, Xuehong ; Han, Jiali ; Stampfer, Meir J. ; Smith-Warner, Stephanie A. ; Zeleniuch-Jacquotte, Anne ; Le Marchand, Loic ; Yuan, Jian Min ; Butler, Lesley M. ; Koh, Woon Puay ; Wang, Renwei ; Gao, Yu Tang ; Ericson, Ulrika ; Sonestedt, Emily ; Ziegler, Regina G. ; Freedman, Neal D. ; Visvanathan, Kala ; Jones, Miranda R. ; Relton, Caroline ; Brennan, Paul ; Johansson, Mattias ; Ueland, Per M. / Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. In: American Journal of Clinical Nutrition. 2017 ; Vol. 105, No. 6. pp. 1314-1326.

@article{69a24fb78a054360a1d46f1ef821ab71,

title = "Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations",

abstract = "Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.",

keywords = "Biomarker, Lung Cancer Cohort Consortium, One-carbon metabolism, Tryptophan metabolism, Vitamin status",

author = "{\O}ivind Midttun and Despoina Theofylaktopoulou and Adrian McCann and Anouar Fanidi and Muller, {David C.} and Klaus Meyer and Arve Ulvik and Wei Zheng and Shu, {Xiao Ou} and Xiang, {Yong Bing} and Ross Prentice and Thomson, {Cynthia A.} and Mary Pettinger and Giles, {Graham G.} and Allison Hodge and Qiuyin Cai and Blot, {William J.} and Jie Wu and Mikael Johansson and Johan Hultdin and Kjell Grankvist and Stevens, {Victoria L.} and McCullough, {Marjorie L.} and Weinstein, {Stephanie J.} and Demetrius Albanes and Arnulf Langhammer and Kristian Hveem and Marit N{\ae}ss and Sesso, {Howard D.} and Gaziano, {J. Michael} and Buring, {Julie E.} and Lee, {I. Min} and Gianluca Severi and Xuehong Zhang and Jiali Han and Stampfer, {Meir J.} and Smith-Warner, {Stephanie A.} and Anne Zeleniuch-Jacquotte and {Le Marchand}, Loic and Yuan, {Jian Min} and Butler, {Lesley M.} and Koh, {Woon Puay} and Renwei Wang and Gao, {Yu Tang} and Ulrika Ericson and Emily Sonestedt and Ziegler, {Regina G.} and Freedman, {Neal D.} and Kala Visvanathan and Jones, {Miranda R.} and Caroline Relton and Paul Brennan and Mattias Johansson and Ueland, {Per M.}",

note = "Funding Information: Supported by the NIH/National Cancer Institute (NCI) [grant 1U01CA155340-01; to the Lung Cancer Cohort Consortium (LC3)], the Australian National Health and Medical Research Committee (grant 1050198; to the LC3), the US NCI [grants R37 CA070867 and UM1 CA182910 (to the Shanghai Women's Health Study), R01 CA082729 and UM1 CA173640 (to the Shanghai Men's Health Study), and R01 CA092447 and U01 CA202979 (to the Southern Community Cohort Study). The Multiethnic Cohort Study was funded in part by grant U01 CA164973. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study is supported by the Intramural Research Program of the US NCI, NIH, and by US Public Health Service contract HHSN261201500005C from the NCI, Department of Health and Human Services (DHHS). The Campaign Against Cancer and Stroke and the Campaign Against Cancer and Heart Disease acknowledge the State of Maryland, the Maryland Cigarette Restitution Fund, and the National Program of Cancer Registries of the CDC for funds that support the collection and availability of the cancer registry data. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial is supported by contracts from the Division of Cancer Prevention and intramural research funding from the Division of Cancer Epidemiology and Genetics, NCI, US NIH, DHHS. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial was supported by the NIH (grants, UM1CA167552, UM1CA186107, P01CA87969, and R01CA49449). CR is supported by Cancer Research UK grant (C18281/A19169) and the Medical Research Council Integrative Epidemiology Unit at the University of Bristol with funds from the Medical Research Council (MC-UU-12013/2) and the University of Bristol. This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).",

year = "2017",

month = jun,

day = "1",

doi = "10.3945/ajcn.116.151241",

language = "English (US)",

volume = "105",

pages = "1314--1326",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "6",

}

TY - JOUR

T1 - Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations

AU - Midttun, Øivind

AU - Theofylaktopoulou, Despoina

AU - McCann, Adrian

AU - Fanidi, Anouar

AU - Muller, David C.

AU - Meyer, Klaus

AU - Ulvik, Arve

AU - Zheng, Wei

AU - Shu, Xiao Ou

AU - Xiang, Yong Bing

AU - Prentice, Ross

AU - Thomson, Cynthia A.

AU - Pettinger, Mary

AU - Giles, Graham G.

AU - Hodge, Allison

AU - Cai, Qiuyin

AU - Blot, William J.

AU - Wu, Jie

AU - Johansson, Mikael

AU - Hultdin, Johan

AU - Grankvist, Kjell

AU - Stevens, Victoria L.

AU - McCullough, Marjorie L.

AU - Weinstein, Stephanie J.

AU - Albanes, Demetrius

AU - Langhammer, Arnulf

AU - Hveem, Kristian

AU - Næss, Marit

AU - Sesso, Howard D.

AU - Gaziano, J. Michael

AU - Buring, Julie E.

AU - Lee, I. Min

AU - Severi, Gianluca

AU - Zhang, Xuehong

AU - Han, Jiali

AU - Stampfer, Meir J.

AU - Smith-Warner, Stephanie A.

AU - Zeleniuch-Jacquotte, Anne

AU - Le Marchand, Loic

AU - Yuan, Jian Min

AU - Butler, Lesley M.

AU - Koh, Woon Puay

AU - Wang, Renwei

AU - Gao, Yu Tang

AU - Ericson, Ulrika

AU - Sonestedt, Emily

AU - Ziegler, Regina G.

AU - Freedman, Neal D.

AU - Visvanathan, Kala

AU - Jones, Miranda R.

AU - Relton, Caroline

AU - Brennan, Paul

AU - Johansson, Mattias

AU - Ueland, Per M.

N1 - Funding Information: Supported by the NIH/National Cancer Institute (NCI) [grant 1U01CA155340-01; to the Lung Cancer Cohort Consortium (LC3)], the Australian National Health and Medical Research Committee (grant 1050198; to the LC3), the US NCI [grants R37 CA070867 and UM1 CA182910 (to the Shanghai Women's Health Study), R01 CA082729 and UM1 CA173640 (to the Shanghai Men's Health Study), and R01 CA092447 and U01 CA202979 (to the Southern Community Cohort Study). The Multiethnic Cohort Study was funded in part by grant U01 CA164973. The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study is supported by the Intramural Research Program of the US NCI, NIH, and by US Public Health Service contract HHSN261201500005C from the NCI, Department of Health and Human Services (DHHS). The Campaign Against Cancer and Stroke and the Campaign Against Cancer and Heart Disease acknowledge the State of Maryland, the Maryland Cigarette Restitution Fund, and the National Program of Cancer Registries of the CDC for funds that support the collection and availability of the cancer registry data. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial is supported by contracts from the Division of Cancer Prevention and intramural research funding from the Division of Cancer Epidemiology and Genetics, NCI, US NIH, DHHS. The Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial was supported by the NIH (grants, UM1CA167552, UM1CA186107, P01CA87969, and R01CA49449). CR is supported by Cancer Research UK grant (C18281/A19169) and the Medical Research Council Integrative Epidemiology Unit at the University of Bristol with funds from the Medical Research Council (MC-UU-12013/2) and the University of Bristol. This is an open access article distributed under the CC-BY license (http://creativecommons.org/licenses/by/3.0/).

PY - 2017/6/1

Y1 - 2017/6/1

N2 - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

AB - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.

KW - Biomarker

KW - Lung Cancer Cohort Consortium

KW - One-carbon metabolism

KW - Tryptophan metabolism

KW - Vitamin status

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UR - http://www.scopus.com/inward/citedby.url?scp=85020506629&partnerID=8YFLogxK

U2 - 10.3945/ajcn.116.151241

DO - 10.3945/ajcn.116.151241

M3 - Article

C2 - 28424186

AN - SCOPUS:85020506629

VL - 105

SP - 1314

EP - 1326

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 6

ER -