Abstract
Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1314-1326 |
| Number of pages | 13 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 105 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 1 2017 |
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Keywords
- Biomarker
- Lung Cancer Cohort Consortium
- One-carbon metabolism
- Tryptophan metabolism
- Vitamin status
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations. / Midttun, Øivind; Theofylaktopoulou, Despoina; McCann, Adrian; Fanidi, Anouar; Muller, David C.; Meyer, Klaus; Ulvik, Arve; Zheng, Wei; Shu, Xiao Ou; Xiang, Yong Bing; Prentice, Ross; Thomson, Cynthia; Pettinger, Mary; Giles, Graham G.; Hodge, Allison; Cai, Qiuyin; Blot, William J.; Wu, Jie; Johansson, Mikael; Hultdin, Johan; Grankvist, Kjell; Stevens, Victoria L.; McCullough, Marjorie L.; Weinstein, Stephanie J.; Albanes, Demetrius; Langhammer, Arnulf; Hveem, Kristian; Næss, Marit; Sesso, Howard D.; Gaziano, J. Michael; Buring, Julie E.; Lee, I. Min; Severi, Gianluca; Zhang, Xuehong; Han, Jiali; Stampfer, Meir J.; Smith-Warner, Stephanie A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Yuan, Jian Min; Butler, Lesley M.; Koh, Woon Puay; Wang, Renwei; Gao, Yu Tang; Ericson, Ulrika; Sonestedt, Emily; Ziegler, Regina G.; Freedman, Neal D.; Visvanathan, Kala; Jones, Miranda R.; Relton, Caroline; Brennan, Paul; Johansson, Mattias; Ueland, Per M.
In: American Journal of Clinical Nutrition, Vol. 105, No. 6, 01.06.2017, p. 1314-1326.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Circulating concentrations of biomarkers and metabolites related to Vitamin status, one-carbon and the kynurenine pathways in US, Nordic, Asian, and Australian populations
AU - Midttun, Øivind
AU - Theofylaktopoulou, Despoina
AU - McCann, Adrian
AU - Fanidi, Anouar
AU - Muller, David C.
AU - Meyer, Klaus
AU - Ulvik, Arve
AU - Zheng, Wei
AU - Shu, Xiao Ou
AU - Xiang, Yong Bing
AU - Prentice, Ross
AU - Thomson, Cynthia
AU - Pettinger, Mary
AU - Giles, Graham G.
AU - Hodge, Allison
AU - Cai, Qiuyin
AU - Blot, William J.
AU - Wu, Jie
AU - Johansson, Mikael
AU - Hultdin, Johan
AU - Grankvist, Kjell
AU - Stevens, Victoria L.
AU - McCullough, Marjorie L.
AU - Weinstein, Stephanie J.
AU - Albanes, Demetrius
AU - Langhammer, Arnulf
AU - Hveem, Kristian
AU - Næss, Marit
AU - Sesso, Howard D.
AU - Gaziano, J. Michael
AU - Buring, Julie E.
AU - Lee, I. Min
AU - Severi, Gianluca
AU - Zhang, Xuehong
AU - Han, Jiali
AU - Stampfer, Meir J.
AU - Smith-Warner, Stephanie A.
AU - Zeleniuch-Jacquotte, Anne
AU - Le Marchand, Loic
AU - Yuan, Jian Min
AU - Butler, Lesley M.
AU - Koh, Woon Puay
AU - Wang, Renwei
AU - Gao, Yu Tang
AU - Ericson, Ulrika
AU - Sonestedt, Emily
AU - Ziegler, Regina G.
AU - Freedman, Neal D.
AU - Visvanathan, Kala
AU - Jones, Miranda R.
AU - Relton, Caroline
AU - Brennan, Paul
AU - Johansson, Mattias
AU - Ueland, Per M.
PY - 2017/6/1
Y1 - 2017/6/1
N2 - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.
AB - Background: Circulating concentrations of biomarkers that are related to Vitamin status vary by factors such as diet, fortification, and supplement use. Published biomarker concentrations have also been influenced by the variation across laboratories, which complicates a comparison of results from different studies. Objective: We robustly and comprehensively assessed differences in biomarkers that are related to Vitamin status across geographic regions. Design: The trial was a cross-sectional study in which we investigated 38 biomarkers that are related to Vitamin status and one-carbon and tryptophan metabolism in serum and plasma from 5314 healthy control subjects representing 20 cohorts recruited from the United States, Nordic countries, Asia, and Australia, participating in the Lung Cancer Cohort Consortium. All samples were analyzed in a centralized laboratory. Results: Circulating concentrations of riboflavin, pyridoxal 5≤-phosphate, folate, Vitamin B-12, all-trans retinol, 25-hydroxyVitamin D, and a-tocopherol as well as combined Vitamin scores that were based on these nutrients showed that the general B-Vitamin concentration was highest in the United States and that the B Vitamins and lipid soluble Vitamins were low in Asians. Conversely, circulating concentrations of metabolites that are inversely related to B Vitamins involved in the one-carbon and kynurenine pathways were high in Asians. The high B-Vitamin concentration in the United States appears to be driven mainly by multiVitamin-supplement users. Conclusions: The observed differences likely reflect the variation in intake of Vitamins and, in particular, the widespread multiVitamin-supplement use in the United States. The results provide valuable information about the differences in biomarkerconcentrations in populations across continents. Am J Clin Nutr 2017;105:1314-26.
KW - Biomarker
KW - Lung Cancer Cohort Consortium
KW - One-carbon metabolism
KW - Tryptophan metabolism
KW - Vitamin status
UR - http://www.scopus.com/inward/record.url?scp=85020506629&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85020506629&partnerID=8YFLogxK
U2 - 10.3945/ajcn.116.151241
DO - 10.3945/ajcn.116.151241
M3 - Article
C2 - 28424186
AN - SCOPUS:85020506629
VL - 105
SP - 1314
EP - 1326
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 6
ER -