Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)

Tricia L. Larose, Florence Guida, Anouar Fanidi, Arnulf Langhammer, Kristian Kveem, Victoria L. Stevens, Eric J. Jacobs, Stephanie A. Smith-Warner, Edward Giovannucci, Demetrius Albanes, Stephanie J. Weinstein, Neal D. Freedman, Ross Prentice, Mary Pettinger, Cynthia A. Thomson, Qiuyin Cai, Jie Wu, William J. Blot, Alan A. Arslan, Anne Zeleniuch-JacquotteLoic Le Marchand, Lynne R. Wilkens, Christopher A. Haiman, Xuehong Zhang, Meir J. Stampfer, Allison M. Hodge, Graham G. Giles, Gianluca Severi, Mikael Johansson, Kjell Grankvist, Renwei Wang, Jian Min Yuan, Yu Tang Gao, Woon Puay Koh, Xiao Ou Shu, Wei Zheng, Yong Bing Xiang, Honglan Li, Qing Lan, Kala Visvanathan, Judith Hoffman Bolton, Per Magne Ueland, Øivind Midttun, Neil Caporaso, Mark Purdue, Howard D. Sesso, Julie E. Buring, I. Min Lee, J. Michael Gaziano, Jonas Manjer, Hans Brunnström, Paul Brennan, Mattias Johansson

Research output: Contribution to journalArticle

Abstract

Background: Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine—a nicotine metabolite and biomarker of recent tobacco exposure—provides additional information on lung cancer risk. Methods: The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis. Results: We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR) per 500 nmol/L increase in cotinine (OR 500 ): 1.39, 95% confidence interval (CI): 1.32–1.47]. Cotinine concentrations consistent with active smoking (115 nmol/L) were common in former smokers (cases: 14.6%; controls: 9.2%) and rare in never smokers (cases: 2.7%; controls: 0.8%). Former and never smokers with cotinine concentrations indicative of active smoking (115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUC integrated : 0.69, 95% CI: 0.68–0.71) yielded a small improvement over self-reported smoking alone (AUC smoke : 0.66, 95% CI: 0.64–0.68) (P ¼ 1.5x10 –9 ). Conclusions: Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.

Original languageEnglish (US)
Pages (from-to)1760-1771
Number of pages12
JournalInternational Journal of Epidemiology
Volume47
Issue number6
DOIs
StatePublished - Jan 1 2018

Fingerprint

Cotinine
Lung Neoplasms
Smoking
Confidence Intervals
Area Under Curve
Odds Ratio
Nicotine
ROC Curve
Smoke
Self Report
Tobacco
Epidemiologic Studies
Cohort Studies
Biomarkers
Logistic Models
Prospective Studies

Keywords

  • Biomarker
  • Case-control
  • Consortium
  • Cotinine
  • Lung cancer
  • Prospective

ASJC Scopus subject areas

  • Epidemiology

Cite this

Larose, T. L., Guida, F., Fanidi, A., Langhammer, A., Kveem, K., Stevens, V. L., ... Johansson, M. (2018). Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). International Journal of Epidemiology, 47(6), 1760-1771. https://doi.org/10.1093/ije/dyy100

Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). / Larose, Tricia L.; Guida, Florence; Fanidi, Anouar; Langhammer, Arnulf; Kveem, Kristian; Stevens, Victoria L.; Jacobs, Eric J.; Smith-Warner, Stephanie A.; Giovannucci, Edward; Albanes, Demetrius; Weinstein, Stephanie J.; Freedman, Neal D.; Prentice, Ross; Pettinger, Mary; Thomson, Cynthia A.; Cai, Qiuyin; Wu, Jie; Blot, William J.; Arslan, Alan A.; Zeleniuch-Jacquotte, Anne; Le Marchand, Loic; Wilkens, Lynne R.; Haiman, Christopher A.; Zhang, Xuehong; Stampfer, Meir J.; Hodge, Allison M.; Giles, Graham G.; Severi, Gianluca; Johansson, Mikael; Grankvist, Kjell; Wang, Renwei; Yuan, Jian Min; Gao, Yu Tang; Koh, Woon Puay; Shu, Xiao Ou; Zheng, Wei; Xiang, Yong Bing; Li, Honglan; Lan, Qing; Visvanathan, Kala; Bolton, Judith Hoffman; Ueland, Per Magne; Midttun, Øivind; Caporaso, Neil; Purdue, Mark; Sesso, Howard D.; Buring, Julie E.; Lee, I. Min; Michael Gaziano, J.; Manjer, Jonas; Brunnström, Hans; Brennan, Paul; Johansson, Mattias.

In: International Journal of Epidemiology, Vol. 47, No. 6, 01.01.2018, p. 1760-1771.

Research output: Contribution to journalArticle

Larose, TL, Guida, F, Fanidi, A, Langhammer, A, Kveem, K, Stevens, VL, Jacobs, EJ, Smith-Warner, SA, Giovannucci, E, Albanes, D, Weinstein, SJ, Freedman, ND, Prentice, R, Pettinger, M, Thomson, CA, Cai, Q, Wu, J, Blot, WJ, Arslan, AA, Zeleniuch-Jacquotte, A, Le Marchand, L, Wilkens, LR, Haiman, CA, Zhang, X, Stampfer, MJ, Hodge, AM, Giles, GG, Severi, G, Johansson, M, Grankvist, K, Wang, R, Yuan, JM, Gao, YT, Koh, WP, Shu, XO, Zheng, W, Xiang, YB, Li, H, Lan, Q, Visvanathan, K, Bolton, JH, Ueland, PM, Midttun, Ø, Caporaso, N, Purdue, M, Sesso, HD, Buring, JE, Lee, IM, Michael Gaziano, J, Manjer, J, Brunnström, H, Brennan, P & Johansson, M 2018, 'Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)', International Journal of Epidemiology, vol. 47, no. 6, pp. 1760-1771. https://doi.org/10.1093/ije/dyy100
Larose, Tricia L. ; Guida, Florence ; Fanidi, Anouar ; Langhammer, Arnulf ; Kveem, Kristian ; Stevens, Victoria L. ; Jacobs, Eric J. ; Smith-Warner, Stephanie A. ; Giovannucci, Edward ; Albanes, Demetrius ; Weinstein, Stephanie J. ; Freedman, Neal D. ; Prentice, Ross ; Pettinger, Mary ; Thomson, Cynthia A. ; Cai, Qiuyin ; Wu, Jie ; Blot, William J. ; Arslan, Alan A. ; Zeleniuch-Jacquotte, Anne ; Le Marchand, Loic ; Wilkens, Lynne R. ; Haiman, Christopher A. ; Zhang, Xuehong ; Stampfer, Meir J. ; Hodge, Allison M. ; Giles, Graham G. ; Severi, Gianluca ; Johansson, Mikael ; Grankvist, Kjell ; Wang, Renwei ; Yuan, Jian Min ; Gao, Yu Tang ; Koh, Woon Puay ; Shu, Xiao Ou ; Zheng, Wei ; Xiang, Yong Bing ; Li, Honglan ; Lan, Qing ; Visvanathan, Kala ; Bolton, Judith Hoffman ; Ueland, Per Magne ; Midttun, Øivind ; Caporaso, Neil ; Purdue, Mark ; Sesso, Howard D. ; Buring, Julie E. ; Lee, I. Min ; Michael Gaziano, J. ; Manjer, Jonas ; Brunnström, Hans ; Brennan, Paul ; Johansson, Mattias. / Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3). In: International Journal of Epidemiology. 2018 ; Vol. 47, No. 6. pp. 1760-1771.
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title = "Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)",
abstract = "Background: Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine—a nicotine metabolite and biomarker of recent tobacco exposure—provides additional information on lung cancer risk. Methods: The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis. Results: We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR) per 500 nmol/L increase in cotinine (OR 500 ): 1.39, 95{\%} confidence interval (CI): 1.32–1.47]. Cotinine concentrations consistent with active smoking (115 nmol/L) were common in former smokers (cases: 14.6{\%}; controls: 9.2{\%}) and rare in never smokers (cases: 2.7{\%}; controls: 0.8{\%}). Former and never smokers with cotinine concentrations indicative of active smoking (115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUC integrated : 0.69, 95{\%} CI: 0.68–0.71) yielded a small improvement over self-reported smoking alone (AUC smoke : 0.66, 95{\%} CI: 0.64–0.68) (P ¼ 1.5x10 –9 ). Conclusions: Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.",
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TY - JOUR

T1 - Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3)

AU - Larose, Tricia L.

AU - Guida, Florence

AU - Fanidi, Anouar

AU - Langhammer, Arnulf

AU - Kveem, Kristian

AU - Stevens, Victoria L.

AU - Jacobs, Eric J.

AU - Smith-Warner, Stephanie A.

AU - Giovannucci, Edward

AU - Albanes, Demetrius

AU - Weinstein, Stephanie J.

AU - Freedman, Neal D.

AU - Prentice, Ross

AU - Pettinger, Mary

AU - Thomson, Cynthia A.

AU - Cai, Qiuyin

AU - Wu, Jie

AU - Blot, William J.

AU - Arslan, Alan A.

AU - Zeleniuch-Jacquotte, Anne

AU - Le Marchand, Loic

AU - Wilkens, Lynne R.

AU - Haiman, Christopher A.

AU - Zhang, Xuehong

AU - Stampfer, Meir J.

AU - Hodge, Allison M.

AU - Giles, Graham G.

AU - Severi, Gianluca

AU - Johansson, Mikael

AU - Grankvist, Kjell

AU - Wang, Renwei

AU - Yuan, Jian Min

AU - Gao, Yu Tang

AU - Koh, Woon Puay

AU - Shu, Xiao Ou

AU - Zheng, Wei

AU - Xiang, Yong Bing

AU - Li, Honglan

AU - Lan, Qing

AU - Visvanathan, Kala

AU - Bolton, Judith Hoffman

AU - Ueland, Per Magne

AU - Midttun, Øivind

AU - Caporaso, Neil

AU - Purdue, Mark

AU - Sesso, Howard D.

AU - Buring, Julie E.

AU - Lee, I. Min

AU - Michael Gaziano, J.

AU - Manjer, Jonas

AU - Brunnström, Hans

AU - Brennan, Paul

AU - Johansson, Mattias

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Background: Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine—a nicotine metabolite and biomarker of recent tobacco exposure—provides additional information on lung cancer risk. Methods: The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis. Results: We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR) per 500 nmol/L increase in cotinine (OR 500 ): 1.39, 95% confidence interval (CI): 1.32–1.47]. Cotinine concentrations consistent with active smoking (115 nmol/L) were common in former smokers (cases: 14.6%; controls: 9.2%) and rare in never smokers (cases: 2.7%; controls: 0.8%). Former and never smokers with cotinine concentrations indicative of active smoking (115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUC integrated : 0.69, 95% CI: 0.68–0.71) yielded a small improvement over self-reported smoking alone (AUC smoke : 0.66, 95% CI: 0.64–0.68) (P ¼ 1.5x10 –9 ). Conclusions: Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.

AB - Background: Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine—a nicotine metabolite and biomarker of recent tobacco exposure—provides additional information on lung cancer risk. Methods: The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis. Results: We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR) per 500 nmol/L increase in cotinine (OR 500 ): 1.39, 95% confidence interval (CI): 1.32–1.47]. Cotinine concentrations consistent with active smoking (115 nmol/L) were common in former smokers (cases: 14.6%; controls: 9.2%) and rare in never smokers (cases: 2.7%; controls: 0.8%). Former and never smokers with cotinine concentrations indicative of active smoking (115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUC integrated : 0.69, 95% CI: 0.68–0.71) yielded a small improvement over self-reported smoking alone (AUC smoke : 0.66, 95% CI: 0.64–0.68) (P ¼ 1.5x10 –9 ). Conclusions: Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.

KW - Biomarker

KW - Case-control

KW - Consortium

KW - Cotinine

KW - Lung cancer

KW - Prospective

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