Circulating intercellular adhesion molecule-1 levels and neutrophil adhesion in stroke

Wayne M. Clark, Bruce M. Coull, Dennis P. Briley, Elizabeth Mainolfi, Robert Rothlein

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

To examine whether changes in leukocyte adhesion properties occur during stroke, we measured circulating serum intercellular adhesion molecule 1 (cICAM-1) levels and neutrophil adhesion in acute stroke, patients at high risk of stroke, and in matched controls. Levels of cICAM-1 were significantly lower in the stroke group (186.2 ± 15.6 ng ml-1) compared to controls (257.7 ± 24.8) and risks (257.7 ± 16.5). Neutrophil adhesion was significantly higher in the stroke group (23.6 ± 4.3%; n = 14) compared to controls (9.7 ± 2.3%; n = 12) and risks (12.7 ± 2.5%; n = 13). These data suggest that changes in leukocyte adhesion dynamics are occuring in acute stroke.

Original languageEnglish (US)
Pages (from-to)123-125
Number of pages3
JournalJournal of Neuroimmunology
Volume44
Issue number1
DOIs
StatePublished - Apr 1993
Externally publishedYes

Keywords

  • Cell adhesion
  • Intercellular adhesion molecules
  • Leukocytes
  • Stroke

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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