Circulating Procollagen Type III N-Terminal Peptide and Mortality Risk in African Americans With Heart Failure

Ibrahim N. Mansour, Adam P. Bress, Vicki Groo, Sahar Ismail, Grace Wu, Shitalben R. Patel, Julio D. Duarte, Rick A Kittles, Thomas D. Stamos, Larisa H. Cavallari

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Procollagen type III N-terminal peptide (PIIINP) is a biomarker of cardiac fibrosis that is associated with heart failure prognosis in whites. Its prognostic significance in African Americans is unknown. We sought to determine whether PIIINP is associated with outcomes in African Americans with heart failure. Methods and Results: Blood was collected from 138 African Americans with heart failure for determining PIIINP and genetic ancestry, and patients were followed prospectively for death or hospitalization for heart failure. PIIINP was inversely correlated with West African ancestry (R 2 = 0.061; P = .010). PIIINP > 4.88 ng/mL was associated with all-cause mortality on univariate (hazard ratio [HR] 4.9, 95% confidence interval [CI] 2.2-11.0; P <.001) and multivariate (HR 5.8; 95% CI 1.9-17.3; P = .002) analyses over a median follow-up period of 3 years. We also observed an increased risk for the combined outcome of all-cause mortality or hospitalization for heart failure with PIIINP > 4.88 ng/mL on univariate (HR 2.6, 95% CI 1.6-5.0; P <.001) and multivariate (HR 2.4, 95% CI 1.2-4.7; P = .016) analyses. Conclusions: High circulating PIIINP is associated with poor outcomes in African Americans with chronic heart failure, suggesting that PIIINP may be useful in identifying African Americans who may benefit from additional therapy to combat fibrosis as a means of improving prognosis.

Original languageEnglish (US)
JournalJournal of Cardiac Failure
DOIs
StateAccepted/In press - Jun 15 2015
Externally publishedYes

Fingerprint

African Americans
Heart Failure
Mortality
Confidence Intervals
Fibrosis
procollagen Type III-N-terminal peptide
Hospitalization
Biomarkers

Keywords

  • African American
  • Fibrosis
  • Heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Circulating Procollagen Type III N-Terminal Peptide and Mortality Risk in African Americans With Heart Failure. / Mansour, Ibrahim N.; Bress, Adam P.; Groo, Vicki; Ismail, Sahar; Wu, Grace; Patel, Shitalben R.; Duarte, Julio D.; Kittles, Rick A; Stamos, Thomas D.; Cavallari, Larisa H.

In: Journal of Cardiac Failure, 15.06.2015.

Research output: Contribution to journalArticle

Mansour, Ibrahim N. ; Bress, Adam P. ; Groo, Vicki ; Ismail, Sahar ; Wu, Grace ; Patel, Shitalben R. ; Duarte, Julio D. ; Kittles, Rick A ; Stamos, Thomas D. ; Cavallari, Larisa H. / Circulating Procollagen Type III N-Terminal Peptide and Mortality Risk in African Americans With Heart Failure. In: Journal of Cardiac Failure. 2015.
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abstract = "Background: Procollagen type III N-terminal peptide (PIIINP) is a biomarker of cardiac fibrosis that is associated with heart failure prognosis in whites. Its prognostic significance in African Americans is unknown. We sought to determine whether PIIINP is associated with outcomes in African Americans with heart failure. Methods and Results: Blood was collected from 138 African Americans with heart failure for determining PIIINP and genetic ancestry, and patients were followed prospectively for death or hospitalization for heart failure. PIIINP was inversely correlated with West African ancestry (R 2 = 0.061; P = .010). PIIINP > 4.88 ng/mL was associated with all-cause mortality on univariate (hazard ratio [HR] 4.9, 95{\%} confidence interval [CI] 2.2-11.0; P <.001) and multivariate (HR 5.8; 95{\%} CI 1.9-17.3; P = .002) analyses over a median follow-up period of 3 years. We also observed an increased risk for the combined outcome of all-cause mortality or hospitalization for heart failure with PIIINP > 4.88 ng/mL on univariate (HR 2.6, 95{\%} CI 1.6-5.0; P <.001) and multivariate (HR 2.4, 95{\%} CI 1.2-4.7; P = .016) analyses. Conclusions: High circulating PIIINP is associated with poor outcomes in African Americans with chronic heart failure, suggesting that PIIINP may be useful in identifying African Americans who may benefit from additional therapy to combat fibrosis as a means of improving prognosis.",
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AU - Mansour, Ibrahim N.

AU - Bress, Adam P.

AU - Groo, Vicki

AU - Ismail, Sahar

AU - Wu, Grace

AU - Patel, Shitalben R.

AU - Duarte, Julio D.

AU - Kittles, Rick A

AU - Stamos, Thomas D.

AU - Cavallari, Larisa H.

PY - 2015/6/15

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N2 - Background: Procollagen type III N-terminal peptide (PIIINP) is a biomarker of cardiac fibrosis that is associated with heart failure prognosis in whites. Its prognostic significance in African Americans is unknown. We sought to determine whether PIIINP is associated with outcomes in African Americans with heart failure. Methods and Results: Blood was collected from 138 African Americans with heart failure for determining PIIINP and genetic ancestry, and patients were followed prospectively for death or hospitalization for heart failure. PIIINP was inversely correlated with West African ancestry (R 2 = 0.061; P = .010). PIIINP > 4.88 ng/mL was associated with all-cause mortality on univariate (hazard ratio [HR] 4.9, 95% confidence interval [CI] 2.2-11.0; P <.001) and multivariate (HR 5.8; 95% CI 1.9-17.3; P = .002) analyses over a median follow-up period of 3 years. We also observed an increased risk for the combined outcome of all-cause mortality or hospitalization for heart failure with PIIINP > 4.88 ng/mL on univariate (HR 2.6, 95% CI 1.6-5.0; P <.001) and multivariate (HR 2.4, 95% CI 1.2-4.7; P = .016) analyses. Conclusions: High circulating PIIINP is associated with poor outcomes in African Americans with chronic heart failure, suggesting that PIIINP may be useful in identifying African Americans who may benefit from additional therapy to combat fibrosis as a means of improving prognosis.

AB - Background: Procollagen type III N-terminal peptide (PIIINP) is a biomarker of cardiac fibrosis that is associated with heart failure prognosis in whites. Its prognostic significance in African Americans is unknown. We sought to determine whether PIIINP is associated with outcomes in African Americans with heart failure. Methods and Results: Blood was collected from 138 African Americans with heart failure for determining PIIINP and genetic ancestry, and patients were followed prospectively for death or hospitalization for heart failure. PIIINP was inversely correlated with West African ancestry (R 2 = 0.061; P = .010). PIIINP > 4.88 ng/mL was associated with all-cause mortality on univariate (hazard ratio [HR] 4.9, 95% confidence interval [CI] 2.2-11.0; P <.001) and multivariate (HR 5.8; 95% CI 1.9-17.3; P = .002) analyses over a median follow-up period of 3 years. We also observed an increased risk for the combined outcome of all-cause mortality or hospitalization for heart failure with PIIINP > 4.88 ng/mL on univariate (HR 2.6, 95% CI 1.6-5.0; P <.001) and multivariate (HR 2.4, 95% CI 1.2-4.7; P = .016) analyses. Conclusions: High circulating PIIINP is associated with poor outcomes in African Americans with chronic heart failure, suggesting that PIIINP may be useful in identifying African Americans who may benefit from additional therapy to combat fibrosis as a means of improving prognosis.

KW - African American

KW - Fibrosis

KW - Heart failure

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