Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits

Rick A Kittles, Jeffrey C. Long, Andrew W. Bergen, Monica Eggert, Matti Virkkunen, Markku Linnoila, David Goldman

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Association between Y chromosome haplotype variation and alcohol dependence and related personality traits was investigated in a large sample of psychiatrically diagnosed Finnish males. Haplotypes were constructed for 359 individuals using alleles at eight loci (seven microsatellite loci and a nucleotide substitution in the DYZ3 alphoid satellite locus). A cladogram linking the 102 observed haplotype configurations was constructed by using parsimony with a single-step mutation model. Then, a series of contingency tables nested according to the cladogram hierarchy were used to test for association between Y haplotype and alcohol dependence. Finally, using only alcohol-dependent subjects, we tested for association between Y haplotype and personality variables postulated to define subtypes of alcoholism - antisocial personality disorder, novelty seeking, harm avoidance, and reward dependence. Significant association with alcohol dependence was observed at three Y haplotype clades, with significance levels of P = 0.002, P = 0.020, and P = 0.010. Within alcohol-dependent subjects, no relationship was revealed between Y haplotype and antisocial personality disorder, novelty seeking, harm avoidance, or reward dependence. These results demonstrate, by using a fully objective association design, that differences among Y chromosomes contribute to variation in vulnerability to alcohol dependence. However, they do not demonstrate an association between Y haplotype and the personality variables thought to underlie the subtypes of alcoholism.

Original languageEnglish (US)
Pages (from-to)4204-4209
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume96
Issue number7
DOIs
StatePublished - Mar 30 1999
Externally publishedYes

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Y Chromosome
Haplotypes
Alcoholism
Personality
Antisocial Personality Disorder
Reward
Alcohols
Microsatellite Repeats
Nucleotides
Alleles
Mutation

ASJC Scopus subject areas

  • Genetics
  • General

Cite this

Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits. / Kittles, Rick A; Long, Jeffrey C.; Bergen, Andrew W.; Eggert, Monica; Virkkunen, Matti; Linnoila, Markku; Goldman, David.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, No. 7, 30.03.1999, p. 4204-4209.

Research output: Contribution to journalArticle

Kittles, Rick A ; Long, Jeffrey C. ; Bergen, Andrew W. ; Eggert, Monica ; Virkkunen, Matti ; Linnoila, Markku ; Goldman, David. / Cladistic association analysis of Y chromosome effects on alcohol dependence and related personality traits. In: Proceedings of the National Academy of Sciences of the United States of America. 1999 ; Vol. 96, No. 7. pp. 4204-4209.
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