Class i lysine deacetylases facilitate glucocorticoid-induced transcription

Vineela Kadiyala, Nina M. Patrick, Wana Mathieu, Rosa Jaime-Frias, Naruekamol Pookhao, Lingling An, Catharine L. Smith

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

Background:KDACis impair GR transactivation of the MMTV promoter, but their impact on cellular target genes is unknown. Results:KDACi or KDAC depletion suppresses transactivation of about 50% of GR target genes. Conclusion:KDAC1 is required for efficient GR transactivation in a gene-selective fashion. Significance:Because KDACs facilitate GR transactivation, clinical KDACi use may have a major impact on GR signaling.

Original languageEnglish (US)
Pages (from-to)28900-28912
Number of pages13
JournalJournal of Biological Chemistry
Volume288
Issue number40
DOIs
StatePublished - Oct 4 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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