ClC-3

More than just a volume-sensitive Cl - channel

Carmelle V. Remillard, Jason Yuan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Pulmonary vascular medial hypertrophy due to enhanced pulmonary artery smooth muscle cell (PASMC) proliferation and/or decreased PASMC apoptosis is a primary cause of increased pulmonary vascular resistance and arterial pressure in patients with pulmonary arterial hypertension. While many factors can contribute to this form of vascular remodeling, it is generally agreed upon that altered transmembrane ion flux via ion channels is involved. While much focus has centered on the role of cations and cation channels in controlling PASMC contraction and proliferation, anion efflux via Cl - channels has recently gained interest for its role in SMC proliferation, differentiation, migration, contraction, and angiogenesis. In this issue, Dai et al. report that the putative volume-sensitive ClC-3 channel is upregulated in PASMC from monocrotaline-induced pulmonary hypertensive rats and in inflammatory cytokine-treated canine PASMC. They also provide evidence that ClC-3 upregulation may protect against oxidative stress-induced PASMC necrosis, thereby improving PASMC survival and promoting medial hypertrophy.

Original languageEnglish (US)
Pages (from-to)1-2
Number of pages2
JournalBritish Journal of Pharmacology
Volume145
Issue number1
DOIs
StatePublished - May 2005
Externally publishedYes

Fingerprint

Pulmonary Artery
Smooth Muscle Myocytes
Hypertrophy
Cations
Cell Proliferation
Monocrotaline
Lung
Muscle Contraction
Ion Channels
Pulmonary Hypertension
Vascular Resistance
Anions
Blood Vessels
Canidae
Cell Survival
Arterial Pressure
Oxidative Stress
Necrosis
Up-Regulation
Ions

Keywords

  • Cell survival
  • ClC-3
  • Inflammation
  • Monocrotaline
  • Proliferation
  • Pulmonary arterial hypertension
  • Vascular smooth muscle

ASJC Scopus subject areas

  • Pharmacology

Cite this

ClC-3 : More than just a volume-sensitive Cl - channel. / Remillard, Carmelle V.; Yuan, Jason.

In: British Journal of Pharmacology, Vol. 145, No. 1, 05.2005, p. 1-2.

Research output: Contribution to journalArticle

Remillard, Carmelle V. ; Yuan, Jason. / ClC-3 : More than just a volume-sensitive Cl - channel. In: British Journal of Pharmacology. 2005 ; Vol. 145, No. 1. pp. 1-2.
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