"Click" synthesis of small molecule probes for activity-based fingerprinting of matrix metalloproteases

Jun Wang, Mahesh Uttamchandani, Junqi Li, Mingyu Hu, Shao Q. Yao

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

By using "Click Chemistry", we achieved the facile synthesis of various affinity-based hydroxamate probes that enable generation of activity-based fingerprints of a variety of metalloproteases, including matrix metalloproteases (MMPs), in proteomics experiments.

Original languageEnglish (US)
Pages (from-to)3783-3785
Number of pages3
JournalChemical Communications
Issue number36
DOIs
StatePublished - Jan 1 2006
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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