Clinical and computed tomographic predictors of chronic bronchitis in COPD

A cross sectional analysis of the COPDGene study

Victor Kim, Adam Davey, Alejandro P. Comellas, Meilan K. Han, George Washko, Carlos H. Martinez, David Lynch, Jin H. Lee, Edwin K. Silverman, James D. Crapo, Barry J. Make, Gerard J. Criner, Homayoon Farzadegan, Samantha Bragan, Stacey Cayetano, Jeffrey Curtis, Ella Kazerooni, Nicola Hanania, Philip Alapat, Venkata Bandi & 168 others Kalpalatha Guntupalli, Elizabeth Guy, Antara Mallampalli, Charles Trinh, Mustafa Atik, Hasan Al-Azzawi, Marc Willis, Susan Pinero, Linda Fahr, Arun Nachiappan, Collin Bray, L. Alexander Frigini, Carlos Farinas, David Katz, Jose Freytes, Anne Marie Marciel, Dawn DeMeo, Craig Hersh, Francine Jacobson, Hiroto Hatabu, Peter Clarke, Ritu Gill, Andetta Hunsaker, Beatrice Trotman-Dickenson, Rachna Madan, R. Graham Barr, Byron Thomashow, John Austin, Belinda D'Souza, Neil MacIntyre, Lacey Washington, H. Page McAdams, Richard Rosiello, Timothy Bresnahan, Joseph Bradley, Sharon Kuong, Steven Meller, Suzanne Roland, Charlene McEvoy, Joseph Tashjian, Robert Wise, Nadia Hansel, Robert Brown, Gregory Diette, Karen Horton, Richard Casaburi, Janos Porszasz, Hans Fischer, Matt Budoff, Mehdi Rambod, Amir Sharafkhaneh, Hirani Kamal, Roham Darvishi, Dennis Niewoehner, Quentin Anderson, Kathryn Rice, Audrey Caine, Marilyn Foreman, Gloria Westney, Eugene Berkowitz, Russell Bowler, Joyce Schroeder, Valerie Hale, John Armstrong, Debra Dyer, Jonathan Chung, Christian Cox, Nathaniel Marchetti, Aditi Satti, A. James Mamary, Robert Steiner, Chandra Dass, Libby Cone, William Bailey, Mark Dransfield, Michael Wells, Surya Bhatt, Hrudaya Nath, Satinder Singh, Joe Ramsdell, Paul Friedman, Alejandro Cornellas, John Newell, Edwin J.R. van Beek, Fernando Martinez, Christine Wendt, Tadashi Allen, Frank Sciurba, Joel Weissfeld, Carl Fuhrman, Jessica Bon, Danielle Hooper, Antonio Anzueto, Sandra Adams, Carlos Orozco, Mario Ruiz, Amy Mumbower, Ariel Kruger, Carlos Restrepo, Michael Lane, Jaleh Akhavan, Mustafa Al Qaisi, Terri Beaty, Jennifer Black-Shinn, Eugene R. Bleecker, Russell P. Bowler, Stephanie Bratschie, Peter J. Castaldic, Michael Cho, Christian W. Cox, Harvey O. Coxson, Thomas Croxton, Ronald G. Crystal, Jeffrey L. Curtis, Deanna Cusick, Dawn L. DeMeo, Jennifer G. Dy, Douglas Everett, Marilyn G. Foreman, Weiniu Gan, Shoshana Ginsburg, Nadia N. Hansel, Megan E. Hardin, Craig P. Hersh, Jacqueline Hetmanski, Eric A. Hoffman, James C. Hogg, John Hokanson, John E. Hokanson, Robert Jensen, Raul San Jose Estepar, Philip F. Judy, Gregory Kinney, Alex Kluiber, Ruthie Knowles, Nan Laird, Christoph Lange, Rochelle Lantz, Sharon M. Lutz, Manuel Mattheisen, Merry Lynn McDonaldc, Alexander McKenzie, Sandra Melanson, John D. Newell, Margaret M. Parker, Randel Plant, Lisa Postow, Delia Prieto, Michael A. Province, Elizabeth A. Regan, John J. Reilly, Stephen I. Rennard, James Rossc, Stephanie Santorico, Joyce D. Schroeder, Jered Sieren, Arkadiusz Sitek, Lori Stepp, Douglas Stinson, E. Rand Sutherland, Duncan C. Thomas, John W. Walsh, Emily S. Wan, Andre Williams, Carla Wilson, Jordan Zach, Jin Zhou, Edwin van Beek

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.Methods: We divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene®) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5%) and no chronic bronchitis (CB-, n = 2040, 75.5%). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA%) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10 mm and 15 mm (Pi10 and Pi15, respectively), % emphysema, %gas trapping, were calculated using 3D Slicer (http://www.slicer.org).Results: There were no differences in % emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6%, p = 0.347) or % gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6%, p = 0.272) between groups. Mean segmental WA% (63.0 ± 3.2 vs. 62.0 ± 3.1%, p < 0.0001), Pi10 (3.72 ± 0.15 vs. 3.69 ± 0.14 mm, p < 0.0001), and Pi15 (5.24 ± 0.22 vs. 5.17 ± 0.20, p < 0.0001) were greater in the CB + group. Greater percentages of gastroesophageal reflux, allergic rhinitis, histories of asthma and acute bronchitis, exposures to dusts and occupational exposures, and current smokers were seen in the CB + group. In multivariate binomial logistic regression, male gender, Caucasian race, a lower FEV1%, allergic rhinitis, history of acute bronchitis, current smoking, and increased airway wall thickness increased odds for having CB.Conclusions: Histories of asthma, allergic rhinitis, acute bronchitis, current smoking, a lower FEV1%, Caucasian race, male gender, and increased airway wall thickness are associated with CB. These data provide clinical and radiologic correlations to the clinical phenotype of CB.

Original languageEnglish (US)
Article number52
JournalRespiratory Research
Volume15
Issue number1
DOIs
StatePublished - Apr 27 2014
Externally publishedYes

Fingerprint

Chronic Bronchitis
Chronic Obstructive Pulmonary Disease
Cross-Sectional Studies
Bronchitis
Smoking
Emphysema
Occupational Exposure
Asthma
Gases
Molecular Epidemiology
Bronchi
Gastroesophageal Reflux
Dust
Dyspnea

Keywords

  • Airway thickening
  • Asthma
  • Chronic bronchitis
  • Chronic obstructive pulmonary disease

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Clinical and computed tomographic predictors of chronic bronchitis in COPD : A cross sectional analysis of the COPDGene study. / Kim, Victor; Davey, Adam; Comellas, Alejandro P.; Han, Meilan K.; Washko, George; Martinez, Carlos H.; Lynch, David; Lee, Jin H.; Silverman, Edwin K.; Crapo, James D.; Make, Barry J.; Criner, Gerard J.; Farzadegan, Homayoon; Bragan, Samantha; Cayetano, Stacey; Curtis, Jeffrey; Kazerooni, Ella; Hanania, Nicola; Alapat, Philip; Bandi, Venkata; Guntupalli, Kalpalatha; Guy, Elizabeth; Mallampalli, Antara; Trinh, Charles; Atik, Mustafa; Al-Azzawi, Hasan; Willis, Marc; Pinero, Susan; Fahr, Linda; Nachiappan, Arun; Bray, Collin; Frigini, L. Alexander; Farinas, Carlos; Katz, David; Freytes, Jose; Marciel, Anne Marie; DeMeo, Dawn; Hersh, Craig; Jacobson, Francine; Hatabu, Hiroto; Clarke, Peter; Gill, Ritu; Hunsaker, Andetta; Trotman-Dickenson, Beatrice; Madan, Rachna; Barr, R. Graham; Thomashow, Byron; Austin, John; D'Souza, Belinda; MacIntyre, Neil; Washington, Lacey; McAdams, H. Page; Rosiello, Richard; Bresnahan, Timothy; Bradley, Joseph; Kuong, Sharon; Meller, Steven; Roland, Suzanne; McEvoy, Charlene; Tashjian, Joseph; Wise, Robert; Hansel, Nadia; Brown, Robert; Diette, Gregory; Horton, Karen; Casaburi, Richard; Porszasz, Janos; Fischer, Hans; Budoff, Matt; Rambod, Mehdi; Sharafkhaneh, Amir; Kamal, Hirani; Darvishi, Roham; Niewoehner, Dennis; Anderson, Quentin; Rice, Kathryn; Caine, Audrey; Foreman, Marilyn; Westney, Gloria; Berkowitz, Eugene; Bowler, Russell; Schroeder, Joyce; Hale, Valerie; Armstrong, John; Dyer, Debra; Chung, Jonathan; Cox, Christian; Marchetti, Nathaniel; Satti, Aditi; Mamary, A. James; Steiner, Robert; Dass, Chandra; Cone, Libby; Bailey, William; Dransfield, Mark; Wells, Michael; Bhatt, Surya; Nath, Hrudaya; Singh, Satinder; Ramsdell, Joe; Friedman, Paul; Cornellas, Alejandro; Newell, John; van Beek, Edwin J.R.; Martinez, Fernando; Wendt, Christine; Allen, Tadashi; Sciurba, Frank; Weissfeld, Joel; Fuhrman, Carl; Bon, Jessica; Hooper, Danielle; Anzueto, Antonio; Adams, Sandra; Orozco, Carlos; Ruiz, Mario; Mumbower, Amy; Kruger, Ariel; Restrepo, Carlos; Lane, Michael; Akhavan, Jaleh; Al Qaisi, Mustafa; Beaty, Terri; Black-Shinn, Jennifer; Bleecker, Eugene R.; Bowler, Russell P.; Bratschie, Stephanie; Castaldic, Peter J.; Cho, Michael; Cox, Christian W.; Coxson, Harvey O.; Croxton, Thomas; Crystal, Ronald G.; Curtis, Jeffrey L.; Cusick, Deanna; DeMeo, Dawn L.; Dy, Jennifer G.; Everett, Douglas; Foreman, Marilyn G.; Gan, Weiniu; Ginsburg, Shoshana; Hansel, Nadia N.; Hardin, Megan E.; Hersh, Craig P.; Hetmanski, Jacqueline; Hoffman, Eric A.; Hogg, James C.; Hokanson, John; Hokanson, John E.; Jensen, Robert; Jose Estepar, Raul San; Judy, Philip F.; Kinney, Gregory; Kluiber, Alex; Knowles, Ruthie; Laird, Nan; Lange, Christoph; Lantz, Rochelle; Lutz, Sharon M.; Mattheisen, Manuel; McDonaldc, Merry Lynn; McKenzie, Alexander; Melanson, Sandra; Newell, John D.; Parker, Margaret M.; Plant, Randel; Postow, Lisa; Prieto, Delia; Province, Michael A.; Regan, Elizabeth A.; Reilly, John J.; Rennard, Stephen I.; Rossc, James; Santorico, Stephanie; Schroeder, Joyce D.; Sieren, Jered; Sitek, Arkadiusz; Stepp, Lori; Stinson, Douglas; Sutherland, E. Rand; Thomas, Duncan C.; Walsh, John W.; Wan, Emily S.; Williams, Andre; Wilson, Carla; Zach, Jordan; Zhou, Jin; van Beek, Edwin.

In: Respiratory Research, Vol. 15, No. 1, 52, 27.04.2014.

Research output: Contribution to journalArticle

Kim, V, Davey, A, Comellas, AP, Han, MK, Washko, G, Martinez, CH, Lynch, D, Lee, JH, Silverman, EK, Crapo, JD, Make, BJ, Criner, GJ, Farzadegan, H, Bragan, S, Cayetano, S, Curtis, J, Kazerooni, E, Hanania, N, Alapat, P, Bandi, V, Guntupalli, K, Guy, E, Mallampalli, A, Trinh, C, Atik, M, Al-Azzawi, H, Willis, M, Pinero, S, Fahr, L, Nachiappan, A, Bray, C, Frigini, LA, Farinas, C, Katz, D, Freytes, J, Marciel, AM, DeMeo, D, Hersh, C, Jacobson, F, Hatabu, H, Clarke, P, Gill, R, Hunsaker, A, Trotman-Dickenson, B, Madan, R, Barr, RG, Thomashow, B, Austin, J, D'Souza, B, MacIntyre, N, Washington, L, McAdams, HP, Rosiello, R, Bresnahan, T, Bradley, J, Kuong, S, Meller, S, Roland, S, McEvoy, C, Tashjian, J, Wise, R, Hansel, N, Brown, R, Diette, G, Horton, K, Casaburi, R, Porszasz, J, Fischer, H, Budoff, M, Rambod, M, Sharafkhaneh, A, Kamal, H, Darvishi, R, Niewoehner, D, Anderson, Q, Rice, K, Caine, A, Foreman, M, Westney, G, Berkowitz, E, Bowler, R, Schroeder, J, Hale, V, Armstrong, J, Dyer, D, Chung, J, Cox, C, Marchetti, N, Satti, A, Mamary, AJ, Steiner, R, Dass, C, Cone, L, Bailey, W, Dransfield, M, Wells, M, Bhatt, S, Nath, H, Singh, S, Ramsdell, J, Friedman, P, Cornellas, A, Newell, J, van Beek, EJR, Martinez, F, Wendt, C, Allen, T, Sciurba, F, Weissfeld, J, Fuhrman, C, Bon, J, Hooper, D, Anzueto, A, Adams, S, Orozco, C, Ruiz, M, Mumbower, A, Kruger, A, Restrepo, C, Lane, M, Akhavan, J, Al Qaisi, M, Beaty, T, Black-Shinn, J, Bleecker, ER, Bowler, RP, Bratschie, S, Castaldic, PJ, Cho, M, Cox, CW, Coxson, HO, Croxton, T, Crystal, RG, Curtis, JL, Cusick, D, DeMeo, DL, Dy, JG, Everett, D, Foreman, MG, Gan, W, Ginsburg, S, Hansel, NN, Hardin, ME, Hersh, CP, Hetmanski, J, Hoffman, EA, Hogg, JC, Hokanson, J, Hokanson, JE, Jensen, R, Jose Estepar, RS, Judy, PF, Kinney, G, Kluiber, A, Knowles, R, Laird, N, Lange, C, Lantz, R, Lutz, SM, Mattheisen, M, McDonaldc, ML, McKenzie, A, Melanson, S, Newell, JD, Parker, MM, Plant, R, Postow, L, Prieto, D, Province, MA, Regan, EA, Reilly, JJ, Rennard, SI, Rossc, J, Santorico, S, Schroeder, JD, Sieren, J, Sitek, A, Stepp, L, Stinson, D, Sutherland, ER, Thomas, DC, Walsh, JW, Wan, ES, Williams, A, Wilson, C, Zach, J, Zhou, J & van Beek, E 2014, 'Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study', Respiratory Research, vol. 15, no. 1, 52. https://doi.org/10.1186/1465-9921-15-52
Kim, Victor ; Davey, Adam ; Comellas, Alejandro P. ; Han, Meilan K. ; Washko, George ; Martinez, Carlos H. ; Lynch, David ; Lee, Jin H. ; Silverman, Edwin K. ; Crapo, James D. ; Make, Barry J. ; Criner, Gerard J. ; Farzadegan, Homayoon ; Bragan, Samantha ; Cayetano, Stacey ; Curtis, Jeffrey ; Kazerooni, Ella ; Hanania, Nicola ; Alapat, Philip ; Bandi, Venkata ; Guntupalli, Kalpalatha ; Guy, Elizabeth ; Mallampalli, Antara ; Trinh, Charles ; Atik, Mustafa ; Al-Azzawi, Hasan ; Willis, Marc ; Pinero, Susan ; Fahr, Linda ; Nachiappan, Arun ; Bray, Collin ; Frigini, L. Alexander ; Farinas, Carlos ; Katz, David ; Freytes, Jose ; Marciel, Anne Marie ; DeMeo, Dawn ; Hersh, Craig ; Jacobson, Francine ; Hatabu, Hiroto ; Clarke, Peter ; Gill, Ritu ; Hunsaker, Andetta ; Trotman-Dickenson, Beatrice ; Madan, Rachna ; Barr, R. Graham ; Thomashow, Byron ; Austin, John ; D'Souza, Belinda ; MacIntyre, Neil ; Washington, Lacey ; McAdams, H. Page ; Rosiello, Richard ; Bresnahan, Timothy ; Bradley, Joseph ; Kuong, Sharon ; Meller, Steven ; Roland, Suzanne ; McEvoy, Charlene ; Tashjian, Joseph ; Wise, Robert ; Hansel, Nadia ; Brown, Robert ; Diette, Gregory ; Horton, Karen ; Casaburi, Richard ; Porszasz, Janos ; Fischer, Hans ; Budoff, Matt ; Rambod, Mehdi ; Sharafkhaneh, Amir ; Kamal, Hirani ; Darvishi, Roham ; Niewoehner, Dennis ; Anderson, Quentin ; Rice, Kathryn ; Caine, Audrey ; Foreman, Marilyn ; Westney, Gloria ; Berkowitz, Eugene ; Bowler, Russell ; Schroeder, Joyce ; Hale, Valerie ; Armstrong, John ; Dyer, Debra ; Chung, Jonathan ; Cox, Christian ; Marchetti, Nathaniel ; Satti, Aditi ; Mamary, A. James ; Steiner, Robert ; Dass, Chandra ; Cone, Libby ; Bailey, William ; Dransfield, Mark ; Wells, Michael ; Bhatt, Surya ; Nath, Hrudaya ; Singh, Satinder ; Ramsdell, Joe ; Friedman, Paul ; Cornellas, Alejandro ; Newell, John ; van Beek, Edwin J.R. ; Martinez, Fernando ; Wendt, Christine ; Allen, Tadashi ; Sciurba, Frank ; Weissfeld, Joel ; Fuhrman, Carl ; Bon, Jessica ; Hooper, Danielle ; Anzueto, Antonio ; Adams, Sandra ; Orozco, Carlos ; Ruiz, Mario ; Mumbower, Amy ; Kruger, Ariel ; Restrepo, Carlos ; Lane, Michael ; Akhavan, Jaleh ; Al Qaisi, Mustafa ; Beaty, Terri ; Black-Shinn, Jennifer ; Bleecker, Eugene R. ; Bowler, Russell P. ; Bratschie, Stephanie ; Castaldic, Peter J. ; Cho, Michael ; Cox, Christian W. ; Coxson, Harvey O. ; Croxton, Thomas ; Crystal, Ronald G. ; Curtis, Jeffrey L. ; Cusick, Deanna ; DeMeo, Dawn L. ; Dy, Jennifer G. ; Everett, Douglas ; Foreman, Marilyn G. ; Gan, Weiniu ; Ginsburg, Shoshana ; Hansel, Nadia N. ; Hardin, Megan E. ; Hersh, Craig P. ; Hetmanski, Jacqueline ; Hoffman, Eric A. ; Hogg, James C. ; Hokanson, John ; Hokanson, John E. ; Jensen, Robert ; Jose Estepar, Raul San ; Judy, Philip F. ; Kinney, Gregory ; Kluiber, Alex ; Knowles, Ruthie ; Laird, Nan ; Lange, Christoph ; Lantz, Rochelle ; Lutz, Sharon M. ; Mattheisen, Manuel ; McDonaldc, Merry Lynn ; McKenzie, Alexander ; Melanson, Sandra ; Newell, John D. ; Parker, Margaret M. ; Plant, Randel ; Postow, Lisa ; Prieto, Delia ; Province, Michael A. ; Regan, Elizabeth A. ; Reilly, John J. ; Rennard, Stephen I. ; Rossc, James ; Santorico, Stephanie ; Schroeder, Joyce D. ; Sieren, Jered ; Sitek, Arkadiusz ; Stepp, Lori ; Stinson, Douglas ; Sutherland, E. Rand ; Thomas, Duncan C. ; Walsh, John W. ; Wan, Emily S. ; Williams, Andre ; Wilson, Carla ; Zach, Jordan ; Zhou, Jin ; van Beek, Edwin. / Clinical and computed tomographic predictors of chronic bronchitis in COPD : A cross sectional analysis of the COPDGene study. In: Respiratory Research. 2014 ; Vol. 15, No. 1.
@article{60118b150e6b442abbbd9686622bc120,
title = "Clinical and computed tomographic predictors of chronic bronchitis in COPD: A cross sectional analysis of the COPDGene study",
abstract = "Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.Methods: We divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene{\circledR}) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5{\%}) and no chronic bronchitis (CB-, n = 2040, 75.5{\%}). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA{\%}) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10 mm and 15 mm (Pi10 and Pi15, respectively), {\%} emphysema, {\%}gas trapping, were calculated using 3D Slicer (http://www.slicer.org).Results: There were no differences in {\%} emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6{\%}, p = 0.347) or {\%} gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6{\%}, p = 0.272) between groups. Mean segmental WA{\%} (63.0 ± 3.2 vs. 62.0 ± 3.1{\%}, p < 0.0001), Pi10 (3.72 ± 0.15 vs. 3.69 ± 0.14 mm, p < 0.0001), and Pi15 (5.24 ± 0.22 vs. 5.17 ± 0.20, p < 0.0001) were greater in the CB + group. Greater percentages of gastroesophageal reflux, allergic rhinitis, histories of asthma and acute bronchitis, exposures to dusts and occupational exposures, and current smokers were seen in the CB + group. In multivariate binomial logistic regression, male gender, Caucasian race, a lower FEV1{\%}, allergic rhinitis, history of acute bronchitis, current smoking, and increased airway wall thickness increased odds for having CB.Conclusions: Histories of asthma, allergic rhinitis, acute bronchitis, current smoking, a lower FEV1{\%}, Caucasian race, male gender, and increased airway wall thickness are associated with CB. These data provide clinical and radiologic correlations to the clinical phenotype of CB.",
keywords = "Airway thickening, Asthma, Chronic bronchitis, Chronic obstructive pulmonary disease",
author = "Victor Kim and Adam Davey and Comellas, {Alejandro P.} and Han, {Meilan K.} and George Washko and Martinez, {Carlos H.} and David Lynch and Lee, {Jin H.} and Silverman, {Edwin K.} and Crapo, {James D.} and Make, {Barry J.} and Criner, {Gerard J.} and Homayoon Farzadegan and Samantha Bragan and Stacey Cayetano and Jeffrey Curtis and Ella Kazerooni and Nicola Hanania and Philip Alapat and Venkata Bandi and Kalpalatha Guntupalli and Elizabeth Guy and Antara Mallampalli and Charles Trinh and Mustafa Atik and Hasan Al-Azzawi and Marc Willis and Susan Pinero and Linda Fahr and Arun Nachiappan and Collin Bray and Frigini, {L. Alexander} and Carlos Farinas and David Katz and Jose Freytes and Marciel, {Anne Marie} and Dawn DeMeo and Craig Hersh and Francine Jacobson and Hiroto Hatabu and Peter Clarke and Ritu Gill and Andetta Hunsaker and Beatrice Trotman-Dickenson and Rachna Madan and Barr, {R. Graham} and Byron Thomashow and John Austin and Belinda D'Souza and Neil MacIntyre and Lacey Washington and McAdams, {H. Page} and Richard Rosiello and Timothy Bresnahan and Joseph Bradley and Sharon Kuong and Steven Meller and Suzanne Roland and Charlene McEvoy and Joseph Tashjian and Robert Wise and Nadia Hansel and Robert Brown and Gregory Diette and Karen Horton and Richard Casaburi and Janos Porszasz and Hans Fischer and Matt Budoff and Mehdi Rambod and Amir Sharafkhaneh and Hirani Kamal and Roham Darvishi and Dennis Niewoehner and Quentin Anderson and Kathryn Rice and Audrey Caine and Marilyn Foreman and Gloria Westney and Eugene Berkowitz and Russell Bowler and Joyce Schroeder and Valerie Hale and John Armstrong and Debra Dyer and Jonathan Chung and Christian Cox and Nathaniel Marchetti and Aditi Satti and Mamary, {A. James} and Robert Steiner and Chandra Dass and Libby Cone and William Bailey and Mark Dransfield and Michael Wells and Surya Bhatt and Hrudaya Nath and Satinder Singh and Joe Ramsdell and Paul Friedman and Alejandro Cornellas and John Newell and {van Beek}, {Edwin J.R.} and Fernando Martinez and Christine Wendt and Tadashi Allen and Frank Sciurba and Joel Weissfeld and Carl Fuhrman and Jessica Bon and Danielle Hooper and Antonio Anzueto and Sandra Adams and Carlos Orozco and Mario Ruiz and Amy Mumbower and Ariel Kruger and Carlos Restrepo and Michael Lane and Jaleh Akhavan and {Al Qaisi}, Mustafa and Terri Beaty and Jennifer Black-Shinn and Bleecker, {Eugene R.} and Bowler, {Russell P.} and Stephanie Bratschie and Castaldic, {Peter J.} and Michael Cho and Cox, {Christian W.} and Coxson, {Harvey O.} and Thomas Croxton and Crystal, {Ronald G.} and Curtis, {Jeffrey L.} and Deanna Cusick and DeMeo, {Dawn L.} and Dy, {Jennifer G.} and Douglas Everett and Foreman, {Marilyn G.} and Weiniu Gan and Shoshana Ginsburg and Hansel, {Nadia N.} and Hardin, {Megan E.} and Hersh, {Craig P.} and Jacqueline Hetmanski and Hoffman, {Eric A.} and Hogg, {James C.} and John Hokanson and Hokanson, {John E.} and Robert Jensen and {Jose Estepar}, {Raul San} and Judy, {Philip F.} and Gregory Kinney and Alex Kluiber and Ruthie Knowles and Nan Laird and Christoph Lange and Rochelle Lantz and Lutz, {Sharon M.} and Manuel Mattheisen and McDonaldc, {Merry Lynn} and Alexander McKenzie and Sandra Melanson and Newell, {John D.} and Parker, {Margaret M.} and Randel Plant and Lisa Postow and Delia Prieto and Province, {Michael A.} and Regan, {Elizabeth A.} and Reilly, {John J.} and Rennard, {Stephen I.} and James Rossc and Stephanie Santorico and Schroeder, {Joyce D.} and Jered Sieren and Arkadiusz Sitek and Lori Stepp and Douglas Stinson and Sutherland, {E. Rand} and Thomas, {Duncan C.} and Walsh, {John W.} and Wan, {Emily S.} and Andre Williams and Carla Wilson and Jordan Zach and Jin Zhou and {van Beek}, Edwin",
year = "2014",
month = "4",
day = "27",
doi = "10.1186/1465-9921-15-52",
language = "English (US)",
volume = "15",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - Clinical and computed tomographic predictors of chronic bronchitis in COPD

T2 - A cross sectional analysis of the COPDGene study

AU - Kim, Victor

AU - Davey, Adam

AU - Comellas, Alejandro P.

AU - Han, Meilan K.

AU - Washko, George

AU - Martinez, Carlos H.

AU - Lynch, David

AU - Lee, Jin H.

AU - Silverman, Edwin K.

AU - Crapo, James D.

AU - Make, Barry J.

AU - Criner, Gerard J.

AU - Farzadegan, Homayoon

AU - Bragan, Samantha

AU - Cayetano, Stacey

AU - Curtis, Jeffrey

AU - Kazerooni, Ella

AU - Hanania, Nicola

AU - Alapat, Philip

AU - Bandi, Venkata

AU - Guntupalli, Kalpalatha

AU - Guy, Elizabeth

AU - Mallampalli, Antara

AU - Trinh, Charles

AU - Atik, Mustafa

AU - Al-Azzawi, Hasan

AU - Willis, Marc

AU - Pinero, Susan

AU - Fahr, Linda

AU - Nachiappan, Arun

AU - Bray, Collin

AU - Frigini, L. Alexander

AU - Farinas, Carlos

AU - Katz, David

AU - Freytes, Jose

AU - Marciel, Anne Marie

AU - DeMeo, Dawn

AU - Hersh, Craig

AU - Jacobson, Francine

AU - Hatabu, Hiroto

AU - Clarke, Peter

AU - Gill, Ritu

AU - Hunsaker, Andetta

AU - Trotman-Dickenson, Beatrice

AU - Madan, Rachna

AU - Barr, R. Graham

AU - Thomashow, Byron

AU - Austin, John

AU - D'Souza, Belinda

AU - MacIntyre, Neil

AU - Washington, Lacey

AU - McAdams, H. Page

AU - Rosiello, Richard

AU - Bresnahan, Timothy

AU - Bradley, Joseph

AU - Kuong, Sharon

AU - Meller, Steven

AU - Roland, Suzanne

AU - McEvoy, Charlene

AU - Tashjian, Joseph

AU - Wise, Robert

AU - Hansel, Nadia

AU - Brown, Robert

AU - Diette, Gregory

AU - Horton, Karen

AU - Casaburi, Richard

AU - Porszasz, Janos

AU - Fischer, Hans

AU - Budoff, Matt

AU - Rambod, Mehdi

AU - Sharafkhaneh, Amir

AU - Kamal, Hirani

AU - Darvishi, Roham

AU - Niewoehner, Dennis

AU - Anderson, Quentin

AU - Rice, Kathryn

AU - Caine, Audrey

AU - Foreman, Marilyn

AU - Westney, Gloria

AU - Berkowitz, Eugene

AU - Bowler, Russell

AU - Schroeder, Joyce

AU - Hale, Valerie

AU - Armstrong, John

AU - Dyer, Debra

AU - Chung, Jonathan

AU - Cox, Christian

AU - Marchetti, Nathaniel

AU - Satti, Aditi

AU - Mamary, A. James

AU - Steiner, Robert

AU - Dass, Chandra

AU - Cone, Libby

AU - Bailey, William

AU - Dransfield, Mark

AU - Wells, Michael

AU - Bhatt, Surya

AU - Nath, Hrudaya

AU - Singh, Satinder

AU - Ramsdell, Joe

AU - Friedman, Paul

AU - Cornellas, Alejandro

AU - Newell, John

AU - van Beek, Edwin J.R.

AU - Martinez, Fernando

AU - Wendt, Christine

AU - Allen, Tadashi

AU - Sciurba, Frank

AU - Weissfeld, Joel

AU - Fuhrman, Carl

AU - Bon, Jessica

AU - Hooper, Danielle

AU - Anzueto, Antonio

AU - Adams, Sandra

AU - Orozco, Carlos

AU - Ruiz, Mario

AU - Mumbower, Amy

AU - Kruger, Ariel

AU - Restrepo, Carlos

AU - Lane, Michael

AU - Akhavan, Jaleh

AU - Al Qaisi, Mustafa

AU - Beaty, Terri

AU - Black-Shinn, Jennifer

AU - Bleecker, Eugene R.

AU - Bowler, Russell P.

AU - Bratschie, Stephanie

AU - Castaldic, Peter J.

AU - Cho, Michael

AU - Cox, Christian W.

AU - Coxson, Harvey O.

AU - Croxton, Thomas

AU - Crystal, Ronald G.

AU - Curtis, Jeffrey L.

AU - Cusick, Deanna

AU - DeMeo, Dawn L.

AU - Dy, Jennifer G.

AU - Everett, Douglas

AU - Foreman, Marilyn G.

AU - Gan, Weiniu

AU - Ginsburg, Shoshana

AU - Hansel, Nadia N.

AU - Hardin, Megan E.

AU - Hersh, Craig P.

AU - Hetmanski, Jacqueline

AU - Hoffman, Eric A.

AU - Hogg, James C.

AU - Hokanson, John

AU - Hokanson, John E.

AU - Jensen, Robert

AU - Jose Estepar, Raul San

AU - Judy, Philip F.

AU - Kinney, Gregory

AU - Kluiber, Alex

AU - Knowles, Ruthie

AU - Laird, Nan

AU - Lange, Christoph

AU - Lantz, Rochelle

AU - Lutz, Sharon M.

AU - Mattheisen, Manuel

AU - McDonaldc, Merry Lynn

AU - McKenzie, Alexander

AU - Melanson, Sandra

AU - Newell, John D.

AU - Parker, Margaret M.

AU - Plant, Randel

AU - Postow, Lisa

AU - Prieto, Delia

AU - Province, Michael A.

AU - Regan, Elizabeth A.

AU - Reilly, John J.

AU - Rennard, Stephen I.

AU - Rossc, James

AU - Santorico, Stephanie

AU - Schroeder, Joyce D.

AU - Sieren, Jered

AU - Sitek, Arkadiusz

AU - Stepp, Lori

AU - Stinson, Douglas

AU - Sutherland, E. Rand

AU - Thomas, Duncan C.

AU - Walsh, John W.

AU - Wan, Emily S.

AU - Williams, Andre

AU - Wilson, Carla

AU - Zach, Jordan

AU - Zhou, Jin

AU - van Beek, Edwin

PY - 2014/4/27

Y1 - 2014/4/27

N2 - Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.Methods: We divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene®) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5%) and no chronic bronchitis (CB-, n = 2040, 75.5%). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA%) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10 mm and 15 mm (Pi10 and Pi15, respectively), % emphysema, %gas trapping, were calculated using 3D Slicer (http://www.slicer.org).Results: There were no differences in % emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6%, p = 0.347) or % gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6%, p = 0.272) between groups. Mean segmental WA% (63.0 ± 3.2 vs. 62.0 ± 3.1%, p < 0.0001), Pi10 (3.72 ± 0.15 vs. 3.69 ± 0.14 mm, p < 0.0001), and Pi15 (5.24 ± 0.22 vs. 5.17 ± 0.20, p < 0.0001) were greater in the CB + group. Greater percentages of gastroesophageal reflux, allergic rhinitis, histories of asthma and acute bronchitis, exposures to dusts and occupational exposures, and current smokers were seen in the CB + group. In multivariate binomial logistic regression, male gender, Caucasian race, a lower FEV1%, allergic rhinitis, history of acute bronchitis, current smoking, and increased airway wall thickness increased odds for having CB.Conclusions: Histories of asthma, allergic rhinitis, acute bronchitis, current smoking, a lower FEV1%, Caucasian race, male gender, and increased airway wall thickness are associated with CB. These data provide clinical and radiologic correlations to the clinical phenotype of CB.

AB - Background: Chronic bronchitis (CB) has been related to poor outcomes in Chronic Obstructive Pulmonary Disease (COPD). From a clinical standpoint, we have shown that subjects with CB in a group with moderate to severe airflow obstruction were younger, more likely to be current smokers, male, Caucasian, had worse health related quality of life, more dyspnea, and increased exacerbation history compared to those without CB. We sought to further refine our clinical characterization of chronic bronchitics in a larger cohort and analyze the CT correlates of CB in COPD subjects. We hypothesized that COPD patients with CB would have thicker airways and a greater history of smoking, acute bronchitis, allergic rhinitis, and occupational exposures compared to those without CB.Methods: We divided 2703 GOLD 1-4 subjects in the Genetic Epidemiology of COPD (COPDGene®) Study into two groups based on symptoms: chronic bronchitis (CB+, n = 663, 24.5%) and no chronic bronchitis (CB-, n = 2040, 75.5%). Subjects underwent extensive clinical characterization, and quantitative CT analysis to calculate mean wall area percent (WA%) of 6 segmental airways was performed using VIDA PW2 (http://www.vidadiagnostics.com). Square roots of the wall areas of bronchi with internal perimeters 10 mm and 15 mm (Pi10 and Pi15, respectively), % emphysema, %gas trapping, were calculated using 3D Slicer (http://www.slicer.org).Results: There were no differences in % emphysema (11.4 ± 12.0 vs. 12.0 ± 12.6%, p = 0.347) or % gas trapping (35.3 ± 21.2 vs. 36.3 ± 20.6%, p = 0.272) between groups. Mean segmental WA% (63.0 ± 3.2 vs. 62.0 ± 3.1%, p < 0.0001), Pi10 (3.72 ± 0.15 vs. 3.69 ± 0.14 mm, p < 0.0001), and Pi15 (5.24 ± 0.22 vs. 5.17 ± 0.20, p < 0.0001) were greater in the CB + group. Greater percentages of gastroesophageal reflux, allergic rhinitis, histories of asthma and acute bronchitis, exposures to dusts and occupational exposures, and current smokers were seen in the CB + group. In multivariate binomial logistic regression, male gender, Caucasian race, a lower FEV1%, allergic rhinitis, history of acute bronchitis, current smoking, and increased airway wall thickness increased odds for having CB.Conclusions: Histories of asthma, allergic rhinitis, acute bronchitis, current smoking, a lower FEV1%, Caucasian race, male gender, and increased airway wall thickness are associated with CB. These data provide clinical and radiologic correlations to the clinical phenotype of CB.

KW - Airway thickening

KW - Asthma

KW - Chronic bronchitis

KW - Chronic obstructive pulmonary disease

UR - http://www.scopus.com/inward/record.url?scp=84903197851&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903197851&partnerID=8YFLogxK

U2 - 10.1186/1465-9921-15-52

DO - 10.1186/1465-9921-15-52

M3 - Article

VL - 15

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

IS - 1

M1 - 52

ER -