Clinical and economic burden of Richter syndrome in inpatient cases of chronic lymphocytic leukemia within the United States, 2001-2010

Grant H. Skrepnek, Wendy R. Tate, Amanda F Baker

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Richter syndrome (RS) is an aggressive transformation of chronic lymphocytic leukemia (CLL) characterized by poor prognoses. The purpose of this study was to assess clinical and economic characteristics of RS within inpatient hospital settings in the United States from 2001 to 2010. This retrospective cohort study employed data from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. Overall, 46 613 cases of RS were observed across 695 080 inpatient cases of CLL, representing a national bill of $ 2.74 billion and involving a 9.3% inpatient mortality rate. Multivariate analyses found decreased national inpatient mortality from 2001 to 2010 of -61.1% ( p<0.001), shorter length of stay of -15.5% ( p<0.001) and higher charges of +20.9% ( p<0.003). Numerous characteristics were also associated with increased likelihoods of death, lengths of stay and charges. Clinically, the fi ndings allow for an increased understanding of population-based RS case-mixes, outcome prediction and clinical risk assessments. The continued burden of illness of either RS or CLL ultimately remains contingent upon the comparative- and cost-eff ectiveness of both existing interventions and those in development.

Original languageEnglish (US)
Pages (from-to)834-840
Number of pages7
JournalLeukemia and Lymphoma
Volume55
Issue number4
DOIs
StatePublished - 2014

Fingerprint

B-Cell Chronic Lymphocytic Leukemia
Inpatients
Economics
Length of Stay
Cost of Illness
Mortality
Quality of Health Care
Diagnosis-Related Groups
Health Services Research
Health Care Costs
Cohort Studies
Multivariate Analysis
Retrospective Studies
Costs and Cost Analysis
Population

Keywords

  • Burden of illness
  • Chronic lymphocytic leukemia
  • Inpatient hospitalizations
  • Richter syndrome

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research
  • Medicine(all)

Cite this

Clinical and economic burden of Richter syndrome in inpatient cases of chronic lymphocytic leukemia within the United States, 2001-2010. / Skrepnek, Grant H.; Tate, Wendy R.; Baker, Amanda F.

In: Leukemia and Lymphoma, Vol. 55, No. 4, 2014, p. 834-840.

Research output: Contribution to journalArticle

@article{01b7f751609548f2b16632d1621f7219,
title = "Clinical and economic burden of Richter syndrome in inpatient cases of chronic lymphocytic leukemia within the United States, 2001-2010",
abstract = "Richter syndrome (RS) is an aggressive transformation of chronic lymphocytic leukemia (CLL) characterized by poor prognoses. The purpose of this study was to assess clinical and economic characteristics of RS within inpatient hospital settings in the United States from 2001 to 2010. This retrospective cohort study employed data from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. Overall, 46 613 cases of RS were observed across 695 080 inpatient cases of CLL, representing a national bill of $ 2.74 billion and involving a 9.3{\%} inpatient mortality rate. Multivariate analyses found decreased national inpatient mortality from 2001 to 2010 of -61.1{\%} ( p<0.001), shorter length of stay of -15.5{\%} ( p<0.001) and higher charges of +20.9{\%} ( p<0.003). Numerous characteristics were also associated with increased likelihoods of death, lengths of stay and charges. Clinically, the fi ndings allow for an increased understanding of population-based RS case-mixes, outcome prediction and clinical risk assessments. The continued burden of illness of either RS or CLL ultimately remains contingent upon the comparative- and cost-eff ectiveness of both existing interventions and those in development.",
keywords = "Burden of illness, Chronic lymphocytic leukemia, Inpatient hospitalizations, Richter syndrome",
author = "Skrepnek, {Grant H.} and Tate, {Wendy R.} and Baker, {Amanda F}",
year = "2014",
doi = "10.3109/10428194.2013.814128",
language = "English (US)",
volume = "55",
pages = "834--840",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Clinical and economic burden of Richter syndrome in inpatient cases of chronic lymphocytic leukemia within the United States, 2001-2010

AU - Skrepnek, Grant H.

AU - Tate, Wendy R.

AU - Baker, Amanda F

PY - 2014

Y1 - 2014

N2 - Richter syndrome (RS) is an aggressive transformation of chronic lymphocytic leukemia (CLL) characterized by poor prognoses. The purpose of this study was to assess clinical and economic characteristics of RS within inpatient hospital settings in the United States from 2001 to 2010. This retrospective cohort study employed data from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. Overall, 46 613 cases of RS were observed across 695 080 inpatient cases of CLL, representing a national bill of $ 2.74 billion and involving a 9.3% inpatient mortality rate. Multivariate analyses found decreased national inpatient mortality from 2001 to 2010 of -61.1% ( p<0.001), shorter length of stay of -15.5% ( p<0.001) and higher charges of +20.9% ( p<0.003). Numerous characteristics were also associated with increased likelihoods of death, lengths of stay and charges. Clinically, the fi ndings allow for an increased understanding of population-based RS case-mixes, outcome prediction and clinical risk assessments. The continued burden of illness of either RS or CLL ultimately remains contingent upon the comparative- and cost-eff ectiveness of both existing interventions and those in development.

AB - Richter syndrome (RS) is an aggressive transformation of chronic lymphocytic leukemia (CLL) characterized by poor prognoses. The purpose of this study was to assess clinical and economic characteristics of RS within inpatient hospital settings in the United States from 2001 to 2010. This retrospective cohort study employed data from the Agency for Healthcare Research and Quality's Healthcare Cost and Utilization Project. Overall, 46 613 cases of RS were observed across 695 080 inpatient cases of CLL, representing a national bill of $ 2.74 billion and involving a 9.3% inpatient mortality rate. Multivariate analyses found decreased national inpatient mortality from 2001 to 2010 of -61.1% ( p<0.001), shorter length of stay of -15.5% ( p<0.001) and higher charges of +20.9% ( p<0.003). Numerous characteristics were also associated with increased likelihoods of death, lengths of stay and charges. Clinically, the fi ndings allow for an increased understanding of population-based RS case-mixes, outcome prediction and clinical risk assessments. The continued burden of illness of either RS or CLL ultimately remains contingent upon the comparative- and cost-eff ectiveness of both existing interventions and those in development.

KW - Burden of illness

KW - Chronic lymphocytic leukemia

KW - Inpatient hospitalizations

KW - Richter syndrome

UR - http://www.scopus.com/inward/record.url?scp=84904327922&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84904327922&partnerID=8YFLogxK

U2 - 10.3109/10428194.2013.814128

DO - 10.3109/10428194.2013.814128

M3 - Article

C2 - 23772638

AN - SCOPUS:84904327922

VL - 55

SP - 834

EP - 840

JO - Leukemia and Lymphoma

JF - Leukemia and Lymphoma

SN - 1042-8194

IS - 4

ER -