Clinical and economic impact of ambulatory care clinical pharmacists in management of dyslipidemia in older adults: The IMPROVE study

Samuel L. Ellis, Barry L. Carter, Daniel C. Malone, Sarah J. Billups, Gary J. Okano, Robert J. Valuck, Debra J. Barnette, Charles D. Sintek, Douglas Covey, Barbara Mason, Sandra Jue, Jannet Carmichael, Kelly Guthrie, Robert Dombrowski, Douglas R. Geraets, Mary Amato

Research output: Contribution to journalArticle

129 Scopus citations

Abstract

We examined the impact of ambulatory care clinical pharmacist interventions on clinical and economic outcomes of 208 patients with dyslipidemia and 229 controls treated at nine Veterans Affairs medical centers. This was a randomized, controlled trial involving patients at high risk of drug-related problems. Only those with dyslipidemia are reported here. In addition to usual medical care, clinical pharmacists were responsible for providing pharmaceutical care for patients in the intervention group. The control group did not receive pharmaceutical care. Seventy-two percent of the intervention group and 70% of controls required secondary prevention according to the National Cholesterol Education Program guidelines. Significantly more patients in the intervention group had a fasting lipid profile compared with controls (p=0.021). The absolute change in total cholesterol (17.7 vs 7.4 mg/dl, p=0.028) and low-density lipoprotein (23.4 vs 12.8 mg/dl, p=0.042) was greater in the intervention than in the control group. There were no differences in patients achieving goal lipid values or in overall costs despite increased visits to pharmacists. Ambulatory care clinical pharmacists can significantly improve dyslipidemia in a practice setting designed to manage many medical and drug-related problems.

Original languageEnglish (US)
Pages (from-to)1508-1516
Number of pages9
JournalPharmacotherapy
Volume20
Issue number12
DOIs
StatePublished - Jan 1 2000
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology (medical)

Fingerprint Dive into the research topics of 'Clinical and economic impact of ambulatory care clinical pharmacists in management of dyslipidemia in older adults: The IMPROVE study'. Together they form a unique fingerprint.

  • Cite this

    Ellis, S. L., Carter, B. L., Malone, D. C., Billups, S. J., Okano, G. J., Valuck, R. J., Barnette, D. J., Sintek, C. D., Covey, D., Mason, B., Jue, S., Carmichael, J., Guthrie, K., Dombrowski, R., Geraets, D. R., & Amato, M. (2000). Clinical and economic impact of ambulatory care clinical pharmacists in management of dyslipidemia in older adults: The IMPROVE study. Pharmacotherapy, 20(12), 1508-1516. https://doi.org/10.1592/phco.20.19.1508.34852