Clinical and Immunological Study of Beta Interferon by Intramuscular Route in Patients with Metastatic Breast Cancer

Jorge R. Quesada, Jordan U. Gutterman, Evan M. Hersh

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

Partially purified human beta interferon (HuIFN-β) was administered to six patients with metastatic breast carcinoma by the intramuscular route at doses of 3 × 106 and 6 × 106 units on a daily schedule. Objective antitumor effects were observed in three patients (one partial remission, two minor responses) in soft tissue and lymph node metastases. Systemic side effects (fatigue, fever, pruritus, nausea, etc.) attributable to the treatment occurred in all patients. Augmenting effects by IFN-β on cell-mediated immunity in vivo (delayed-type hypersensitivity) and in vitro natural killer cell and antibody-dependent cell-mediated cytotoxicity were observed in several patients. The clinical and immunological effects were considered evidence of systemic biological activity despite very low or undetectable serum antiviral activity following administration of this agent.

Original languageEnglish (US)
Pages (from-to)593-599
Number of pages7
JournalJournal of Interferon Research
Volume2
Issue number4
DOIs
StatePublished - Jan 1 1982

ASJC Scopus subject areas

  • Immunology
  • Virology

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