Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia

Viken L. Babikian, Robin L. Brey, Bruce M Coull, L. Dana Dewitt, William M. Feinberg, Edward Feldmann, Richard Furie, E. Nigel Harris, David Hess, Steven Kittner, Michael J. Kushner, Steven R. Levine

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

We reviewed the clinical and laboratory data of 128 patients with cerebrovascular disease and antiphospholipid antibodies. Cases were evenly divided between men and women, and the mean age of the study group was 46 years. Cerebral infarction occurred in 97 patients, and transient hemispheric ischemic attacks without stroke were recorded in 19; 12 suffered ocular ischemia. Systemic lupus erythematosus was diagnosed in 16% of all cases. Histories of systemic thromboembolic events and recurrent miscarriages were noted in 14% of the patients and in 19% of the women, respectively. Evidence of cerebral infarction preceding the index event was present in 30% of cases. During a mean follow-up of 16 months, nine of 96 (9%) patients sustained new cerebral infarctions. Of 72 echocardiographic studies, 16 (22%) showed valvular abnormalities. Cerebral angiography detected intracranial lesions in 24 of 49 patients (49%). These data indicate that antiphospholipid antibodies can be identified in stroke patients without known autoimmune disorders. They also suggest that antiphospholipid antibody-associated cerebrovascular ischemia may be recurrent and often occurs in patients with systemic thromboembolic events. Our findings should help design a prospective clinical trial that will assess the risk of recurrent thromboembolism in this population, identify stroke risk factors, and address therapy.

Original languageEnglish (US)
Pages (from-to)1268-1273
Number of pages6
JournalStroke
Volume21
Issue number9
StatePublished - Sep 1990
Externally publishedYes

Fingerprint

Antiphospholipid Antibodies
Brain Ischemia
Cerebral Infarction
Stroke
Ischemia
Cerebrovascular Disorders
Habitual Abortion
Cerebral Angiography
Thromboembolism
Transient Ischemic Attack
Systemic Lupus Erythematosus
Age Groups
Clinical Trials
Population

Keywords

  • Anticoagulants, anticardiolipin antibodies
  • Anticoagulants, antiphospholipid antibodies
  • Cerebrovascular disorders

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

Cite this

Babikian, V. L., Brey, R. L., Coull, B. M., Dewitt, L. D., Feinberg, W. M., Feldmann, E., ... Levine, S. R. (1990). Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia. Stroke, 21(9), 1268-1273.

Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia. / Babikian, Viken L.; Brey, Robin L.; Coull, Bruce M; Dewitt, L. Dana; Feinberg, William M.; Feldmann, Edward; Furie, Richard; Harris, E. Nigel; Hess, David; Kittner, Steven; Kushner, Michael J.; Levine, Steven R.

In: Stroke, Vol. 21, No. 9, 09.1990, p. 1268-1273.

Research output: Contribution to journalArticle

Babikian, VL, Brey, RL, Coull, BM, Dewitt, LD, Feinberg, WM, Feldmann, E, Furie, R, Harris, EN, Hess, D, Kittner, S, Kushner, MJ & Levine, SR 1990, 'Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia', Stroke, vol. 21, no. 9, pp. 1268-1273.
Babikian VL, Brey RL, Coull BM, Dewitt LD, Feinberg WM, Feldmann E et al. Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia. Stroke. 1990 Sep;21(9):1268-1273.
Babikian, Viken L. ; Brey, Robin L. ; Coull, Bruce M ; Dewitt, L. Dana ; Feinberg, William M. ; Feldmann, Edward ; Furie, Richard ; Harris, E. Nigel ; Hess, David ; Kittner, Steven ; Kushner, Michael J. ; Levine, Steven R. / Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia. In: Stroke. 1990 ; Vol. 21, No. 9. pp. 1268-1273.
@article{62bc4f3d651f4660a208879e69307936,
title = "Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia",
abstract = "We reviewed the clinical and laboratory data of 128 patients with cerebrovascular disease and antiphospholipid antibodies. Cases were evenly divided between men and women, and the mean age of the study group was 46 years. Cerebral infarction occurred in 97 patients, and transient hemispheric ischemic attacks without stroke were recorded in 19; 12 suffered ocular ischemia. Systemic lupus erythematosus was diagnosed in 16{\%} of all cases. Histories of systemic thromboembolic events and recurrent miscarriages were noted in 14{\%} of the patients and in 19{\%} of the women, respectively. Evidence of cerebral infarction preceding the index event was present in 30{\%} of cases. During a mean follow-up of 16 months, nine of 96 (9{\%}) patients sustained new cerebral infarctions. Of 72 echocardiographic studies, 16 (22{\%}) showed valvular abnormalities. Cerebral angiography detected intracranial lesions in 24 of 49 patients (49{\%}). These data indicate that antiphospholipid antibodies can be identified in stroke patients without known autoimmune disorders. They also suggest that antiphospholipid antibody-associated cerebrovascular ischemia may be recurrent and often occurs in patients with systemic thromboembolic events. Our findings should help design a prospective clinical trial that will assess the risk of recurrent thromboembolism in this population, identify stroke risk factors, and address therapy.",
keywords = "Anticoagulants, anticardiolipin antibodies, Anticoagulants, antiphospholipid antibodies, Cerebrovascular disorders",
author = "Babikian, {Viken L.} and Brey, {Robin L.} and Coull, {Bruce M} and Dewitt, {L. Dana} and Feinberg, {William M.} and Edward Feldmann and Richard Furie and Harris, {E. Nigel} and David Hess and Steven Kittner and Kushner, {Michael J.} and Levine, {Steven R.}",
year = "1990",
month = "9",
language = "English (US)",
volume = "21",
pages = "1268--1273",
journal = "Stroke",
issn = "0039-2499",
publisher = "Lippincott Williams and Wilkins",
number = "9",

}

TY - JOUR

T1 - Clinical and laboratory findings in patients with antiphospholipid antibodies and cerebral ischemia

AU - Babikian, Viken L.

AU - Brey, Robin L.

AU - Coull, Bruce M

AU - Dewitt, L. Dana

AU - Feinberg, William M.

AU - Feldmann, Edward

AU - Furie, Richard

AU - Harris, E. Nigel

AU - Hess, David

AU - Kittner, Steven

AU - Kushner, Michael J.

AU - Levine, Steven R.

PY - 1990/9

Y1 - 1990/9

N2 - We reviewed the clinical and laboratory data of 128 patients with cerebrovascular disease and antiphospholipid antibodies. Cases were evenly divided between men and women, and the mean age of the study group was 46 years. Cerebral infarction occurred in 97 patients, and transient hemispheric ischemic attacks without stroke were recorded in 19; 12 suffered ocular ischemia. Systemic lupus erythematosus was diagnosed in 16% of all cases. Histories of systemic thromboembolic events and recurrent miscarriages were noted in 14% of the patients and in 19% of the women, respectively. Evidence of cerebral infarction preceding the index event was present in 30% of cases. During a mean follow-up of 16 months, nine of 96 (9%) patients sustained new cerebral infarctions. Of 72 echocardiographic studies, 16 (22%) showed valvular abnormalities. Cerebral angiography detected intracranial lesions in 24 of 49 patients (49%). These data indicate that antiphospholipid antibodies can be identified in stroke patients without known autoimmune disorders. They also suggest that antiphospholipid antibody-associated cerebrovascular ischemia may be recurrent and often occurs in patients with systemic thromboembolic events. Our findings should help design a prospective clinical trial that will assess the risk of recurrent thromboembolism in this population, identify stroke risk factors, and address therapy.

AB - We reviewed the clinical and laboratory data of 128 patients with cerebrovascular disease and antiphospholipid antibodies. Cases were evenly divided between men and women, and the mean age of the study group was 46 years. Cerebral infarction occurred in 97 patients, and transient hemispheric ischemic attacks without stroke were recorded in 19; 12 suffered ocular ischemia. Systemic lupus erythematosus was diagnosed in 16% of all cases. Histories of systemic thromboembolic events and recurrent miscarriages were noted in 14% of the patients and in 19% of the women, respectively. Evidence of cerebral infarction preceding the index event was present in 30% of cases. During a mean follow-up of 16 months, nine of 96 (9%) patients sustained new cerebral infarctions. Of 72 echocardiographic studies, 16 (22%) showed valvular abnormalities. Cerebral angiography detected intracranial lesions in 24 of 49 patients (49%). These data indicate that antiphospholipid antibodies can be identified in stroke patients without known autoimmune disorders. They also suggest that antiphospholipid antibody-associated cerebrovascular ischemia may be recurrent and often occurs in patients with systemic thromboembolic events. Our findings should help design a prospective clinical trial that will assess the risk of recurrent thromboembolism in this population, identify stroke risk factors, and address therapy.

KW - Anticoagulants, anticardiolipin antibodies

KW - Anticoagulants, antiphospholipid antibodies

KW - Cerebrovascular disorders

UR - http://www.scopus.com/inward/record.url?scp=0025171429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025171429&partnerID=8YFLogxK

M3 - Article

C2 - 2396261

AN - SCOPUS:0025171429

VL - 21

SP - 1268

EP - 1273

JO - Stroke

JF - Stroke

SN - 0039-2499

IS - 9

ER -