Clinical assessment of cognitive decline in adults with down syndrome

Marwan Sabbagh, Jamie O Edgin

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Down syndrome is an intellectual disability requiring periodic monitoring of cognition given the near universal presence of Alzheimer’s Disease related neuropathology and high rates of dementia in middle adulthood. We review current approaches to detecting decline in this population, including informant-based measures, dementia screening tools, and neuroimaging techniques. The challenges for detecting decline in this group are discussed, including the need to take into account premorbid cognitive function as well as medical comorbidity.

Original languageEnglish (US)
Pages (from-to)30-34
Number of pages5
JournalCurrent Alzheimer Research
Volume13
Issue number1
StatePublished - Jan 1 2016

Keywords

  • Alzheimer’s disease
  • Assessment
  • Decline
  • Dementia
  • Down syndrome
  • Neuropsychological
  • Sleep

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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