Clinical differentiation of abscess from neoplasm in newly diagnosed space-occupying lesions of the liver

Stephen A Klotz, Robert L. Penn

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The clinical presentations of liver abscess, hepatoma, and metastatic tumor to the liver may be quite similar, and procedures such as computerized tomography,. radionuclide scanning, and ultrasonography of the liver cannot make a specific diagnosis. Therefore, we compared the clinical presentations of 38 patients seen during the last five years with liver abscess (13 patients), hepatoma (eight patients), and undifferentiated carcinoma metastatic to the liver (17 patients). Patients with liver abscess were distinguished from the other two groups by a significantly shorter prodrome, a history of known risk factors for liver abscess, fever, leukocytosis, and a normal-sized liver (P values all <. 1). A finding of three or more of these criteria correctly identified all cases of liver abscess. Only one of the 25 patients with neoplasms had three of the criteria. The presence of multiple or single lesions, abdominal pain, weight loss, or liver function abnormalities did not differ significantly among the three groups. Thus patients with liver abscess can be reliably differentiated from patients with hepatic neoplasms by clinical criteria alone, and appropriate empiric antibiotic therapy can be started while the diagnosis is being confirmed.

Original languageEnglish (US)
Pages (from-to)1537-1541
Number of pages5
JournalSouthern Medical Journal
Volume80
Issue number12
StatePublished - 1987
Externally publishedYes

Fingerprint

Liver Abscess
Abscess
Liver
Neoplasms
Hepatocellular Carcinoma
Leukocytosis
Liver Neoplasms
Radioisotopes
Abdominal Pain
Weight Loss
Ultrasonography
Fever
Tomography
Anti-Bacterial Agents
Carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Clinical differentiation of abscess from neoplasm in newly diagnosed space-occupying lesions of the liver. / Klotz, Stephen A; Penn, Robert L.

In: Southern Medical Journal, Vol. 80, No. 12, 1987, p. 1537-1541.

Research output: Contribution to journalArticle

@article{94dd329fc08b494ea61beec487209532,
title = "Clinical differentiation of abscess from neoplasm in newly diagnosed space-occupying lesions of the liver",
abstract = "The clinical presentations of liver abscess, hepatoma, and metastatic tumor to the liver may be quite similar, and procedures such as computerized tomography,. radionuclide scanning, and ultrasonography of the liver cannot make a specific diagnosis. Therefore, we compared the clinical presentations of 38 patients seen during the last five years with liver abscess (13 patients), hepatoma (eight patients), and undifferentiated carcinoma metastatic to the liver (17 patients). Patients with liver abscess were distinguished from the other two groups by a significantly shorter prodrome, a history of known risk factors for liver abscess, fever, leukocytosis, and a normal-sized liver (P values all <. 1). A finding of three or more of these criteria correctly identified all cases of liver abscess. Only one of the 25 patients with neoplasms had three of the criteria. The presence of multiple or single lesions, abdominal pain, weight loss, or liver function abnormalities did not differ significantly among the three groups. Thus patients with liver abscess can be reliably differentiated from patients with hepatic neoplasms by clinical criteria alone, and appropriate empiric antibiotic therapy can be started while the diagnosis is being confirmed.",
author = "Klotz, {Stephen A} and Penn, {Robert L.}",
year = "1987",
language = "English (US)",
volume = "80",
pages = "1537--1541",
journal = "Southern Medical Journal",
issn = "0038-4348",
publisher = "Lippincott Williams and Wilkins",
number = "12",

}

TY - JOUR

T1 - Clinical differentiation of abscess from neoplasm in newly diagnosed space-occupying lesions of the liver

AU - Klotz, Stephen A

AU - Penn, Robert L.

PY - 1987

Y1 - 1987

N2 - The clinical presentations of liver abscess, hepatoma, and metastatic tumor to the liver may be quite similar, and procedures such as computerized tomography,. radionuclide scanning, and ultrasonography of the liver cannot make a specific diagnosis. Therefore, we compared the clinical presentations of 38 patients seen during the last five years with liver abscess (13 patients), hepatoma (eight patients), and undifferentiated carcinoma metastatic to the liver (17 patients). Patients with liver abscess were distinguished from the other two groups by a significantly shorter prodrome, a history of known risk factors for liver abscess, fever, leukocytosis, and a normal-sized liver (P values all <. 1). A finding of three or more of these criteria correctly identified all cases of liver abscess. Only one of the 25 patients with neoplasms had three of the criteria. The presence of multiple or single lesions, abdominal pain, weight loss, or liver function abnormalities did not differ significantly among the three groups. Thus patients with liver abscess can be reliably differentiated from patients with hepatic neoplasms by clinical criteria alone, and appropriate empiric antibiotic therapy can be started while the diagnosis is being confirmed.

AB - The clinical presentations of liver abscess, hepatoma, and metastatic tumor to the liver may be quite similar, and procedures such as computerized tomography,. radionuclide scanning, and ultrasonography of the liver cannot make a specific diagnosis. Therefore, we compared the clinical presentations of 38 patients seen during the last five years with liver abscess (13 patients), hepatoma (eight patients), and undifferentiated carcinoma metastatic to the liver (17 patients). Patients with liver abscess were distinguished from the other two groups by a significantly shorter prodrome, a history of known risk factors for liver abscess, fever, leukocytosis, and a normal-sized liver (P values all <. 1). A finding of three or more of these criteria correctly identified all cases of liver abscess. Only one of the 25 patients with neoplasms had three of the criteria. The presence of multiple or single lesions, abdominal pain, weight loss, or liver function abnormalities did not differ significantly among the three groups. Thus patients with liver abscess can be reliably differentiated from patients with hepatic neoplasms by clinical criteria alone, and appropriate empiric antibiotic therapy can be started while the diagnosis is being confirmed.

UR - http://www.scopus.com/inward/record.url?scp=0023605304&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023605304&partnerID=8YFLogxK

M3 - Article

C2 - 2827320

AN - SCOPUS:0023605304

VL - 80

SP - 1537

EP - 1541

JO - Southern Medical Journal

JF - Southern Medical Journal

SN - 0038-4348

IS - 12

ER -