Clinical research device for ovarian cancer detection by optical spectroscopy in the ultraviolet C-visible

Ronie George, Archana Chandrasekaran, Molly A. Brewer, Kenneth D Hatch, Urs Utzinger

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Early detection of ovarian cancer could greatly increase the likelihood of successful treatment. However, present detection techniques are not very effective, and symptoms are more commonly seen in later stage disease. Amino acids, structural proteins, and enzymatic cofactors have endogenous optical properties influenced by precancerous changes and tumor growth. We present the technical details of an optical spectroscopy system used to quantify these properties. A fiber optic probe excites the surface epithelium (origin of 90% of cases) over 270 to 580 nm and collects fluorescence and reflectance at 300 to 800 nm with four or greater orders of magnitude instrument to background suppression. Up to four sites per ovary are investigated on patients giving consent to oophorectomy and the system's in vivo optical evaluation. Data acquisition is completed within 20 s per site. We illustrate design, selection, and development of the components used in the system. Concerns relating to clinical use, performance, calibration, and quality control are addressed. In the future, spectroscopic data will be compared with histological biopsies from the corresponding tissue sites. If proven effective, this technique can be useful in screening women at high risk of developing ovarian cancer to determine whether oophorectomy is necessary.

Original languageEnglish (US)
Article number057009
JournalJournal of Biomedical Optics
Volume15
Issue number5
DOIs
StatePublished - Sep 2010

Fingerprint

Biopsy
Fiber optics
Quality control
Amino acids
Tumors
Data acquisition
Screening
Optical properties
cancer
Fluorescence
Calibration
Tissue
Proteins
Amino Acids
spectroscopy
ovaries
epithelium
quality control
data acquisition
amino acids

Keywords

  • Endoscopy
  • Fiber optic probe
  • Ovarian cancer
  • Tissue fluorescence
  • Tissue spectroscopy
  • UVC excitation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Clinical research device for ovarian cancer detection by optical spectroscopy in the ultraviolet C-visible. / George, Ronie; Chandrasekaran, Archana; Brewer, Molly A.; Hatch, Kenneth D; Utzinger, Urs.

In: Journal of Biomedical Optics, Vol. 15, No. 5, 057009, 09.2010.

Research output: Contribution to journalArticle

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