Clonal chromosome abnormalities in 54 cases of ovarian carcinoma

F. H. Thompson, J. Emerson, David S Alberts, Y. Liu, X. Y. Guan, A. Burgess, S. Fox, R. Taetle, Ronald S Weinstein, R. Makar, D. Powell, J. Trent

Research output: Contribution to journalArticle

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Abstract

As a prelude to assessing the relationship of chromosome alterations to clinical outcome in ovarian carcinoma, we report on the cytogenetic analysis on short-term cultures from 54 patients. All patients had histopathologically confirmed malignancy, with the majority of cases demonstrating serous ovarian adenocarcinomas. Structural alterations were evident in 52 cases, whereas numeric changes were identified in 13 cases. The most notable numeric abnormalities were loss of the X-chromosome ( 9 13 total cases) and +7 ( 3 9 diploid cases). Structural alterations most frequently involved chromosomes 1, 3, 6, 7, 11, and 12. Chromosomal breakpoints were shown to cluster in several chromosomal banding regions, including 1p36, 1p11-q21, 3p23-p10, 7p (especially 7p22), 11p, 11q, 12p13-q12, and 12q24. The frequency of structural alterations involving the following chromosome arms was found to be significantly increased: 1p (p < 0.01), 7p (p < 0.01), 11p (p < 0.01), 11q (p < 0.05), and 12p (p < 0.05). An analysis of the net gain or loss of chromosome segments was also performed, with the most consistent tendency observed being over-representation of 1q and chromosome 7, deletion of 1p, and loss of the X chromosome.

Original languageEnglish (US)
Pages (from-to)33-45
Number of pages13
JournalCancer Genetics and Cytogenetics
Volume73
Issue number1
DOIs
StatePublished - 1994

Fingerprint

Chromosome Aberrations
Chromosomes
X Chromosome
Carcinoma
Chromosomes, Human, Pair 13
Chromosome Deletion
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 7
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Diploidy
Adenocarcinoma
Neoplasms
Monosomy 1p Chromosome 1

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

Thompson, F. H., Emerson, J., Alberts, D. S., Liu, Y., Guan, X. Y., Burgess, A., ... Trent, J. (1994). Clonal chromosome abnormalities in 54 cases of ovarian carcinoma. Cancer Genetics and Cytogenetics, 73(1), 33-45. https://doi.org/10.1016/0165-4608(94)90179-1

Clonal chromosome abnormalities in 54 cases of ovarian carcinoma. / Thompson, F. H.; Emerson, J.; Alberts, David S; Liu, Y.; Guan, X. Y.; Burgess, A.; Fox, S.; Taetle, R.; Weinstein, Ronald S; Makar, R.; Powell, D.; Trent, J.

In: Cancer Genetics and Cytogenetics, Vol. 73, No. 1, 1994, p. 33-45.

Research output: Contribution to journalArticle

Thompson, FH, Emerson, J, Alberts, DS, Liu, Y, Guan, XY, Burgess, A, Fox, S, Taetle, R, Weinstein, RS, Makar, R, Powell, D & Trent, J 1994, 'Clonal chromosome abnormalities in 54 cases of ovarian carcinoma', Cancer Genetics and Cytogenetics, vol. 73, no. 1, pp. 33-45. https://doi.org/10.1016/0165-4608(94)90179-1
Thompson, F. H. ; Emerson, J. ; Alberts, David S ; Liu, Y. ; Guan, X. Y. ; Burgess, A. ; Fox, S. ; Taetle, R. ; Weinstein, Ronald S ; Makar, R. ; Powell, D. ; Trent, J. / Clonal chromosome abnormalities in 54 cases of ovarian carcinoma. In: Cancer Genetics and Cytogenetics. 1994 ; Vol. 73, No. 1. pp. 33-45.
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