Clonal chromosome abnormalities in human breast carcinomas I. Twenty- eight cases with primary disease

F. Thompson, J. Emerson, W. Dalton, J. M. Yang, D. McGee, H. Villar, S. Knox, K. Massey, Ronald S Weinstein, Achyut K Bhattacharyya, J. M. Trent

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Abstract

Cytogenetic analysis was performed on a selected series of short-term cultures of primary breast carcinomas from 28 patients. All patients had histopathologically confirmed malignancies, with the majority (25/28 cases) demonstrating infiltrating ductal carcinoma. All 28 cases evidenced clonal chromosome abnormalities, with 10/28 displaying only numeric aberrations, whereas 18/28 displayed clonal structural alterations. In near-diploid tumors the most common numeric changes were -17 and -19. However, trisomy 7 was the only numeric change in two near-diploid tumors. Structural chromosome alterations were primarily isochromosomes, apparent terminal deletions, and unbalanced non-reciprocal translocations. Chromosomes 1 (10/18-56%) and 6 (8/18-44%) were most frequently altered in this series. Breakpoints of clonal structural abnormalities were shown to cluster to several chromosome segments, including 1p22-q11, 3p11, 6p11-13, 7p11-q11, 8p11-q11, and 19q13. Analysis of the gain or loss of specific chromosome segments revealed that the most consistent tendency was over-representation of 1q, 3q, and 6p.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalGenes Chromosomes and Cancer
Volume7
Issue number4
StatePublished - 1993

Fingerprint

Chromosome Aberrations
Chromosomes
Breast Neoplasms
Diploidy
Isochromosomes
Neoplasms
Chromosomes, Human, Pair 10
Ductal Carcinoma
Chromosomes, Human, Pair 1
Cytogenetic Analysis
Trisomy

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Thompson, F., Emerson, J., Dalton, W., Yang, J. M., McGee, D., Villar, H., ... Trent, J. M. (1993). Clonal chromosome abnormalities in human breast carcinomas I. Twenty- eight cases with primary disease. Genes Chromosomes and Cancer, 7(4), 185-193.

Clonal chromosome abnormalities in human breast carcinomas I. Twenty- eight cases with primary disease. / Thompson, F.; Emerson, J.; Dalton, W.; Yang, J. M.; McGee, D.; Villar, H.; Knox, S.; Massey, K.; Weinstein, Ronald S; Bhattacharyya, Achyut K; Trent, J. M.

In: Genes Chromosomes and Cancer, Vol. 7, No. 4, 1993, p. 185-193.

Research output: Contribution to journalArticle

Thompson, F, Emerson, J, Dalton, W, Yang, JM, McGee, D, Villar, H, Knox, S, Massey, K, Weinstein, RS, Bhattacharyya, AK & Trent, JM 1993, 'Clonal chromosome abnormalities in human breast carcinomas I. Twenty- eight cases with primary disease', Genes Chromosomes and Cancer, vol. 7, no. 4, pp. 185-193.
Thompson F, Emerson J, Dalton W, Yang JM, McGee D, Villar H et al. Clonal chromosome abnormalities in human breast carcinomas I. Twenty- eight cases with primary disease. Genes Chromosomes and Cancer. 1993;7(4):185-193.
Thompson, F. ; Emerson, J. ; Dalton, W. ; Yang, J. M. ; McGee, D. ; Villar, H. ; Knox, S. ; Massey, K. ; Weinstein, Ronald S ; Bhattacharyya, Achyut K ; Trent, J. M. / Clonal chromosome abnormalities in human breast carcinomas I. Twenty- eight cases with primary disease. In: Genes Chromosomes and Cancer. 1993 ; Vol. 7, No. 4. pp. 185-193.
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AU - Villar, H.

AU - Knox, S.

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AU - Trent, J. M.

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