Clostridium difficile infection an overview of the disease and its pathogenesis, epidemiology and interventions

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64 Scopus citations


Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.

Original languageEnglish (US)
Pages (from-to)234-242
Number of pages9
JournalGut Microbes
Issue number4
Publication statusPublished - 2010



  • CDAD
  • CDI
  • Clostridium difficile
  • Hypervirulent
  • Infection
  • Infection control
  • Pathogenesis
  • Spore

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

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