Clostridium difficile infection an overview of the disease and its pathogenesis, epidemiology and interventions

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64 Citations (Scopus)

Abstract

Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.

Original languageEnglish (US)
Pages (from-to)234-242
Number of pages9
JournalGut Microbes
Volume1
Issue number4
DOIs
StatePublished - 2010

Fingerprint

Clostridium Infections
Clostridium difficile
Epidemiology
Disease Outbreaks
Diarrhea
Anti-Bacterial Agents

Keywords

  • CDAD
  • CDI
  • Clostridium difficile
  • Hypervirulent
  • Infection
  • Infection control
  • Pathogenesis
  • Spore

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases
  • Microbiology (medical)
  • Microbiology

Cite this

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abstract = "Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.",
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AB - Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.

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