CLTP and LCAT activity in postmenopausal women

K. Greaves, M. L. Fernanadez, Scott B Going, Tamsen L Bassford

Research output: Contribution to journalArticle

Abstract

The ami of this study was to compare cholesterol ester transfer protein (CETP) and lecithin cholesterol acyltransferase 11.(A I') activities in postmenopausal women not undergoing hormone replacement therapy (noHRT) vs. women undergoing estrogen lephicemem therapy (FRT) or a combined HRT (cHRT). Ie; postmenopausal women 55-70 years of age participated m the study CI-TP und LCAT activities were measured by decreases in the mass of endogenous unesterified cholesterol in incubated plasma samples. Mean total cholesterol (255 ± 38. 213 ± 31 and 261 ±39), HDL cholesterol ((SO t. 11.61 ± 11.59-t 23 ) and total/HDL ratios (4.3 ± 0.5, 3.7±11.51 ±11.51 ± 25) were not different among groups (noHRT, FRT. cHRT. respectn-elv i No differences were found m either ( I TP or LCAT activities among groups, however there was a trend for CL'I P activity to lie higher in the two groups undergoing HRT Mean CETP activities for noHRT, FR1. and cHRT were 15 8, 34 6, 54.3 ninol ml-hr. respectively Mean LCAT activities for the three groups were 62 6, 69.2. 56 7 nmol/ml-hr. respectively This study .suggests that hormone replacement therapy may not affect reverse cholesterol transport bv i CAT and CFTP mediated mechanisms.

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996

Fingerprint

hormone replacement therapy
Hormone Replacement Therapy
cholesteryl ester transfer protein
Hormones
Cholesterol Ester Transfer Proteins
Cholesterol
cholesterol
phosphatidylcholine-choline acyltransferase
chloramphenicol acetyltransferase
Phosphatidylcholine-Sterol O-Acyltransferase
high density lipoprotein cholesterol
HDL Cholesterol
estrogens
Estrogens
Plasmas
therapeutics
sampling

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

CLTP and LCAT activity in postmenopausal women. / Greaves, K.; Fernanadez, M. L.; Going, Scott B; Bassford, Tamsen L.

In: FASEB Journal, Vol. 10, No. 3, 1996.

Research output: Contribution to journalArticle

Greaves, K. ; Fernanadez, M. L. ; Going, Scott B ; Bassford, Tamsen L. / CLTP and LCAT activity in postmenopausal women. In: FASEB Journal. 1996 ; Vol. 10, No. 3.
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