CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model

Ken A. Witt, Patrick T Ronaldson, Karin E. Sandoval, Thomas P Davis

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Peptides have been shown to be potent regulators of central nervous system (CNS) activity. As such, peptide-based drugs can serve as a highly effective means to treat diseases of the CNS. Despite this potential, peptides have limited capacity to permeate across the blood-brain barrier (BBB). Nevertheless, advancing strategies in peptide drug design, delivery systems, and transporter targeting are emerging, with such potential to overcome the restrictive nature of the BBB. This chapter addresses peptide drug delivery into the CNS, and in vivo evaluation of peptide permeability across the BBB using the dual-artery in situ brain perfusion model coupled with the technique of capillary depletion.

Original languageEnglish (US)
Pages (from-to)233-247
Number of pages15
JournalNeuromethods
Volume45
DOIs
StatePublished - 2010

Fingerprint

Brain models
Neurology
Central Nervous System
Arteries
Perfusion
Peptides
Brain
Blood-Brain Barrier
Drug Design
Central Nervous System Diseases
Drug Delivery Systems
Drug delivery
Pharmaceutical Preparations
Permeability

Keywords

  • Blood-brain barrier
  • Capillary depletion
  • In situ brain perfusion
  • Peptide drug delivery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model. / Witt, Ken A.; Ronaldson, Patrick T; Sandoval, Karin E.; Davis, Thomas P.

In: Neuromethods, Vol. 45, 2010, p. 233-247.

Research output: Contribution to journalArticle

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