CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model

Ken A. Witt, Patrick T. Ronaldson, Karin E. Sandoval, Thomas P. Davis

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Peptides have been shown to be potent regulators of central nervous system (CNS) activity. As such, peptide-based drugs can serve as a highly effective means to treat diseases of the CNS. Despite this potential, peptides have limited capacity to permeate across the blood-brain barrier (BBB). Nevertheless, advancing strategies in peptide drug design, delivery systems, and transporter targeting are emerging, with such potential to overcome the restrictive nature of the BBB. This chapter addresses peptide drug delivery into the CNS, and in vivo evaluation of peptide permeability across the BBB using the dual-artery in situ brain perfusion model coupled with the technique of capillary depletion.

Original languageEnglish (US)
Title of host publicationDrug Delivery to the Central Nervous System
EditorsKewal K. Jain
Pages233-247
Number of pages15
DOIs
StatePublished - Jan 15 2010

Publication series

NameNeuromethods
Volume45
ISSN (Print)0893-2336
ISSN (Electronic)1940-6045

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Keywords

  • Blood-brain barrier
  • Capillary depletion
  • In situ brain perfusion
  • Peptide drug delivery

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

Cite this

Witt, K. A., Ronaldson, P. T., Sandoval, K. E., & Davis, T. P. (2010). CNS delivery of peptides across the bbb using the dual-artery in situ brain perfusion model. In K. K. Jain (Ed.), Drug Delivery to the Central Nervous System (pp. 233-247). (Neuromethods; Vol. 45). https://doi.org/10.1007/978-1-60761-529-3_11