CNS drug delivery: Opioid peptides and the blood-brain barrier

Ken A. Witt, Thomas P Davis

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/ modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious "hybrid" peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future.

Original languageEnglish (US)
Article number9
JournalAAPS Journal
Volume8
Issue number1
DOIs
StatePublished - Feb 24 2006

Fingerprint

Central Nervous System Agents
Opioid Peptides
Blood-Brain Barrier
Peptides
Pain
Central Nervous System
Pharmaceutical Preparations
Therapeutics

Keywords

  • Biphalin
  • Delivery strategies
  • DPDPE
  • Transport

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

CNS drug delivery : Opioid peptides and the blood-brain barrier. / Witt, Ken A.; Davis, Thomas P.

In: AAPS Journal, Vol. 8, No. 1, 9, 24.02.2006.

Research output: Contribution to journalArticle

@article{5a1773b958b9458bb54d7adf580eb65d,
title = "CNS drug delivery: Opioid peptides and the blood-brain barrier",
abstract = "Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/ modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious {"}hybrid{"} peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future.",
keywords = "Biphalin, Delivery strategies, DPDPE, Transport",
author = "Witt, {Ken A.} and Davis, {Thomas P}",
year = "2006",
month = "2",
day = "24",
doi = "10.1208/aapsj080109",
language = "English (US)",
volume = "8",
journal = "AAPS Journal",
issn = "1550-7416",
publisher = "Springer New York",
number = "1",

}

TY - JOUR

T1 - CNS drug delivery

T2 - Opioid peptides and the blood-brain barrier

AU - Witt, Ken A.

AU - Davis, Thomas P

PY - 2006/2/24

Y1 - 2006/2/24

N2 - Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/ modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious "hybrid" peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future.

AB - Peptides are key regulators in cellular and intercellular physiological responses and possess enormous promise for the treatment of pathological conditions. Opioid peptide activity within the central nervous system (CNS) is of particular interest for the treatment of pain owing to the elevated potency of peptides and the centrally mediated actions of pain processes. Despite this potential, peptides have seen limited use as clinically viable drugs for the treatment of pain. Reasons for the limited use are primarily based in the physiochemical and biochemical nature of peptides. Numerous approaches have been devised in an attempt to improve peptide drug delivery to the brain, with variable results. This review describes different approaches to peptide design/ modification and provides examples of the value of these strategies to CNS delivery of peptide drugs. The various modes of modification of therapeutic peptides may be amalgamated, creating more efficacious "hybrid" peptides, with synergistic delivery to the CNS. The ongoing development of these strategies provides promise that peptide drugs may be useful for the treatment of pain and other neurologically-based disease states in the future.

KW - Biphalin

KW - Delivery strategies

KW - DPDPE

KW - Transport

UR - http://www.scopus.com/inward/record.url?scp=33644788804&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644788804&partnerID=8YFLogxK

U2 - 10.1208/aapsj080109

DO - 10.1208/aapsj080109

M3 - Article

C2 - 16584136

AN - SCOPUS:33644788804

VL - 8

JO - AAPS Journal

JF - AAPS Journal

SN - 1550-7416

IS - 1

M1 - 9

ER -