Coaxial electrospinning of gelatin/polyvinyl alcohol composite nanofibers and evaluation of their material properties

Valerie Merkle, Xiaoyi Wu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Electrospinning has been used to fabricate nanofibrous scaffolds from a variety of synthetic and natural materials, including polyvinyl alcohol (PVA) and gelatin. Although PVA possesses appealing mechanical properties for tissue engineering applications, it lacks adequate cellular recognition sites, which limits the material's bioactivity. In contrast, gelatin has desirable bioactivity but lacks adequate mechanical properties and can be difficult to handle. Therefore, coaxial electrospinning is employed to create nanofibers of these materials in a core/shell structure with gelatin forming the shell and PVA forming the core of the fibers. In this study, scanning electron microscopy (SEM), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), mechanical testing, and cellular studies were utilized to evaluate the morphology and material properties of coaxially electrospun PVA/gelatin nanocomposite scaffolds in comparison to scaffolds composed of solely PVA or gelatin. This study yields insight into the potential of combining synthetic and natural polymers together in the engineering of composite nanofibers for a variety of tissue engineering applications.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages380-381
Number of pages2
DOIs
StatePublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

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ASJC Scopus subject areas

  • Bioengineering

Cite this

Merkle, V., & Wu, X. (2012). Coaxial electrospinning of gelatin/polyvinyl alcohol composite nanofibers and evaluation of their material properties. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 380-381). [6207123] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6207123