Coaxial transthoracic fine-needle biopsy in patients with a history of malignant lymphoma

G. R. Wittich, K. W. Nowels, R. L. Korn, R. M. Walter, D. E. Lucas, M. D. Dake, R. B. Jeffrey

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Efficacy and safety of coaxial transthoracic fine-needle biopsy were evaluated in 54 patients with a history of malignant lymphoma and new chest lesions. Twenty-one patients had recurrent lymphoma. Correct diagnosis was made in 17 of the 21 patients (81%) after one biopsy. The sensitivity increased to 95% with repeat needle biopsy in three patients. Immunophenotyping (determining phenotype by means of immunologic examination) was essential for a definitive diagnosis of lymphoma in three patients. Non- lymphomatous malignancies were correctly diagnosed in 14 patients. An infectious organism was identified in 11 of 19 patients (58%) with benign lesions. Pneumothorax occurred in eight patients (15%), necessitating placement of a chest tube in two (4%). Mild hemoptysis was observed in four patients (7%). The authors conclude that coaxial transthoracic fine-needle biopsy in patients with a history of lymphoma is safe and accurate. The use of large cutting needles or surgical biopsy can be restricted to patients with false-negative findings at percutaneous biopsy and to patients in whom histologic transformation of lymphoma is suspected.

Original languageEnglish (US)
Pages (from-to)175-178
Number of pages4
JournalRadiology
Volume183
Issue number1
DOIs
StatePublished - Jan 1 1992
Externally publishedYes

Keywords

  • Hodgkin disease, diagnosis
  • Lung, biopsy
  • Lymphatic system, biopsy
  • Lymphoma, diagnosis
  • Thorax, biopsy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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